We know that aspirin can often be safely discontinued after PCI, provided it is not stopped too early. But how early is too early?
In this meta-analysis of 11 RCTs including 37,443 PCI patients—now incorporating the recent NEOMINDSET and TARGET-FIRST trials—we found that aspirin discontinuation at either ≤3 months or ≤1 month, followed by P2Y12 inhibitor monotherapy, reduced bleeding without increasing MACE compared with 12-month DAPT.
The key finding is that while discontinuation within the first month may provide an additional bleeding benefit, it appears to come at the cost of increased stent thrombosis, particularly in patients at higher ischaemic risk.
https://t.co/83VoBaFuiS
Semaglutide ≠ just weight loss! FLOW trial showed kidney AND survival benefits in #T2D + #CKD across #ASCVD, heart failure, and high CV-risk subgroups. Are we starting early enough? 🤔 https://t.co/lfUpMtL4JB
@KatherineTuttl8#JACC#Semaglutide
I had 20 patients in my Pediatric War Injuries Clinic today, for follow-up care.
Of the 20 children, Israel had killed one or both parents of 19 of them.
In moderate-severe secondary #TR & #AFib, rhythm control w/out AF recurrence was linked to 3.65-fold improvement of TR to ≤mild. Rhythm control may help mitigate TR severity; consider before TR intervention. https://t.co/yZ0SKoDIf1
#JACCIMG#vhdTR@MayoClinicCV@konsiont
So let me get this straight…
We don’t have money for SNAP.
We don’t have money for healthcare.
We don’t have money for public schools.
We don’t have money for veteran services.
We don’t have money for affordable housing.
We don’t have money for mental health services.
We don’t have money for roads and infrastructure.
But we have $1.8b for the insurrectionists who stormed the Capitol on January 6th?
Just now finished “The Voice of Hind Rajab” as it finally came to Hulu. If you struggle to put a human face to the genocide in Gaza, then I highly recommend you watch it. Be warned though- you will never be the same
🚨 NO WAYYY:
At a federally-funded prayer event on the National Mall today, MAGA radio host Eric Metaxas told thousands of Christians that God spent two centuries waiting to raise up Donald Trump — to build a ballroom.
His verbatim words:
“It’s hard to believe that it would take two centuries for the Lord to raise up a great man to bring that ballroom finally to stand where it needs to stand. It’s extraordinary. We only had to wait two hundred years.”
The crowd cheered.
Evangelical Christian leaders literally gathering around a gold statue of the president and celebrating it, all while raging against any accusation of idolatry.
This is what idol worship looks like.
🚨 JUST NOW: The entirety of US Congress ERUPTS in a standing ovation when King Charles III drops this line
“Magna Carta is cited in at least 160 Supreme Court cases in 1789, not least as the foundation of the principle that executive power is subject to CHECKS AND BALANCES."
In this #JACCINT NOTION-3 substudy, #PCI reduced #MACE in nonfrail #TAVR patients w/ CAD (15% vs 33%; HR 0.42) but showed no benefit in frail patients, and increased bleeding risk. Frailty assessment matters when deciding on concomitant revascularization https://t.co/U6ey4Ojasz
The Hook
Cardiology trials keep telling you "20% risk reduction."
But what if that same trial meant:
→ 1 in 50 patients helped (NNT 50)
→ 49 of 50 got zero benefit
Welcome to the greatest trick in clinical trials: Relative Risk vs. Absolute Risk. A thread 🧵👇
Destruction of a statue of Jesus in Lebanon is disturbing, but Israel’s genocide is what really demands our outrage.
https://t.co/xVSeeRL4Wx https://t.co/xVSeeRL4Wx