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In physics, an “impedance mismatch” occurs when two systems each work well but are poorly matched.
In this Science Blog guest post, Harvard physicist Matthew Schwartz argues that something similar is happening with AI and science. LLMs are capable at many things, but working with them as you would with a human collaborator isn’t currently the best way to elicit their scientific strengths.
To address this mismatch, Schwartz created a toolkit for exact calculations in quantitative science. Because similar calculations often emerge in very different areas of science, Claude found connections to ecology, population genetics, and a dozen other fields, and Schwartz worked with domain experts to steer it towards interesting questions.
Read more about these projects here: https://t.co/UpgSwMCz7h
What do you want from AI?
We’re launching a new study with Anthropic Interviewer to learn more about your experiences using AI, what role you want it to play in your life and the world, and what you want from the companies building it.
Last December, 81,000 people told us about their hopes and fears about AI in the largest qualitative study ever done. This time, we’re giving participants the option to make their responses public so that anyone, not just Anthropic, can learn from them.
What you tell us will shape The Anthropic Institute’s research and inform the decisions we make. If many people say companies like Anthropic should be doing something differently, that will be on the record, where anyone can point to it.
The study runs Sept 29 to Oct 6 and is open to Free, Pro, and Max users on Claude and Claude Code.
Take part here: https://t.co/MtdU7MZbeY
New on the Science Blog: Yes, Claude can do Nine Loops.
Theoretical physicists predict how particles behave using formulas called scattering amplitudes. These are notoriously hard to compute, so researchers work with layers of increasingly fine corrections called “loops”—each added loop makes the answer more precise but takes exponentially more computation. Most calculations stop at two or three loops. Eight loops was the previous record in a simplified model physicists use as a testing ground (planar N=4 super-Yang-Mills), set by SLAC's Lance Dixon and collaborators.
Last month, physicist and science writer @4gravitons issued a challenge: could an AI push past eight loops in this model, using only the compute budget an academic could reasonably access?
Given a single prompt describing the nine-loop problem, Claude ran largely unsupervised for days in Claude Science and solved it using methods developed by Dixon and his colleagues, at a total cost of a few thousand dollars. Dixon independently verified the result, and von Hippel wrote about the experience for our blog.
Read more: https://t.co/CS2f2qoIhJ
In the Democratic Republic of the Congo, global health organizations including @CEPIvaccines, @WHOAFRO, and @inrb_kinshasa are using Claude to accelerate their response to an outbreak of an unusual Ebola variant.
Read the full piece here: https://t.co/lQKx17Mxc3
Claude has discovered a previously unknown enzyme system hidden in the DNA of bacteriophages. Beside the enzyme’s gene sits a long array of repeating DNA—a structure that looks somewhat similar to CRISPR.
We don’t yet understand what this system does, but only a handful of known systems share its features, and all of them are able to cut, copy, and paste DNA. Historically, the discovery of such programmable systems has helped revolutionize medicine. CRISPR, for instance, is now the foundation of genetic medicines. But it will take much more work to learn what this system does, and whether it can be put to similar use.
Read more: https://t.co/RuEosScSMb
This is the first result from our new molecular biology lab, where a team of Anthropic biologists is using Claude to explore and accelerate fundamental biology research. There, Claude works through data and literature to generate hypotheses and candidate biological systems to study. After our scientists review Claude’s hypotheses, they test the most promising ideas, with all lab work done by our scientists.
We’d like to extend this approach to a broad range of problems—in genomics and in other fields. If you have a proposal for a research question, we’d like to hear from you.
We’re partnering with Accenture on independent evaluation of frontier AI—part of our recent commitment to embed evaluators at Anthropic. Both we and Accenture expect to invest at least $1 billion to build capacity in this area over the next five years. https://t.co/SHVzjpgnfx
Biologists use specialized open-source models for tasks like modeling the structure of molecular systems, designing drug-like molecules, and predicting the effects of genetic mutations. But these models are often expensive to run, potentially limiting their impact.
In our latest Science Blog, we share how Claude was able to optimize inference for more than 30 open-source models, making them 4x faster on average, partly by writing custom software for GPUs. We’re open sourcing all of the optimization code.
Read more: https://t.co/qiuN1jpgpA
AI systems are getting more powerful, and they're increasingly being used to build the next version of themselves. We want to illuminate that progress for the public.
Today, we're sharing three measurements that help track AI development:
1. How much AI R&D is done by AI.
2. How well AI agents are overseen.
3. How compute is allocated.
We provide a snapshot of these metrics from inside Anthropic. Any frontier developer could publish the same measures, and third parties could verify them.
As the world considers pacing the frontier, we should do everything possible to minimize the gap between what frontier labs know and what the public knows. This means better measuring the development of AI, publishing our findings, and giving society an opportunity to decide how to use this information.
Read the full post and methodology: https://t.co/iPFz8Z4ugE
Today we’re opening applications for the Life Sciences Verification Program.
Through the LSVP, life science professionals can use our models—including, for the first time, Mythos—with a new set of safeguards designed to enable the full range of biology-related work. We designed these new safeguards to provide a better experience for biologists and more protection from risk of misuse.
The program is launching in beta for teams of all kinds—from academic labs to startups, pharma companies, and more. We will continue to improve the program and expand access to individual Pro and Max plans over time.
Learn more about these access grants and apply: https://t.co/uALS2lZuN4
We're publishing our most detailed threat intelligence report to date.
It covers how people tried to misuse Claude—for cyberattacks, influence operations, surveillance, biology, and building weapons—and how we found and stopped them.
We disrupted every operation in the report, and used the lessons from them to strengthen our safeguards. Where appropriate, we also shared what we found with authorities and other AI companies.
These cases are not typical: we’re highlighting some of the most sophisticated misuse we’ve seen. But they’re especially important to discuss, because they show us where AI misuse is headed, where our safeguards work, and where they need to improve.
We’re publishing this report so others can spot the same activity on their own platforms, and so we can give the public a clearer view of how emerging threats develop.
Read the report: https://t.co/0EJUnYEgfz