We study human epithelial barriers and their response to infections causing cancer. We make stem cell driven culture models to study epithelial biology invitro
We kicked off the week with an Impromptu Seminar by Francesco Boccellato (@Boc_Lab) on “mucosoids”, human stem-cell-based in-vitro equivalent of a mucosa to study epithelial homeostasis & responses to bacterial infections. Thank you, Francesco & host Adjunct PI Georg Busslinger!
🚨 We are hiring a #postdoc in Quantitative Cell Biology/Biochemistry. Join us if you are interested in using super-resolution STED & cryoET to uncover self- organization dynamics of cell interfaces & glycobiology collab. with WuLab
Deadline 31 August
https://t.co/Jo1WJy0mWj
@krobinson204,@Boc_Lab and I have a MRC-funded PhD (see link below- deadline 10th Jan). At the Uni's of Birmingham, Oxford and @RosFrankInst, you will use advanced organoid and microscopy technologies to understand how we can target the microbiome for stomach cancer prevention.
Mucus protect us from infections, but how? Check our latest publication on Gut Microbes @tandfonline! https://t.co/OzSkcmBWCE. #Mucus in our gut isn't just a gel barrier; it fights microbes too! When our #gut gets inflamed, it makes #antimicrobial peptides. (1/1)
1/2 These are natural antibiotics that we produce to turn mucus into a germ-killing weapon. We have used our #mucosoids to study this. We found #inflammation triggers cells to release germ-fighting proteins into mucus, which can fend off stomach bugs like #Helicobacter pylori.
Hiring! We are looking for a full-time research assistant to join our team at @RosFrankInst to develop organoid systems for workflows on advance imaging. Exciting science and team! #newPI More information below👇 .
https://t.co/l7kpMbrgmf
Interesting study showing how #hpylori mediates epithelial barrier disruption using #Mucosoids. HtrA-Dependent E-Cadherin Shedding Impairs the Epithelial Barrier Function in Primary Gastric Epithelial Cells and Gastric Organoids https://t.co/LHvdN07t0U #mdpiijms via @IJMS_MDPI
Congratulations to Ludwig @UniofOxford’s Francesco Boccellato on receiving the Lee Placito Research Fellowship! The Lee Placito Medical Fund seeks to advance research on cancers and other diseases of the gastrointestinal tract. https://t.co/hl1YR1ecE7