peterbritz

Gap demolitionist, hubby, dad to only girls, grandad, jetski racing & rescueing, sing a little, dance , play 4,5,6&12strings, move the reed - bucketlist mentor

[peterbritz @bpeterb]

Wow..

[Massimo @Rainmaker1973]

A new shot literally regrows knee cartilage.

Researchers at Stanford Medicine have identified a novel strategy to regenerate articular cartilage in knees and potentially prevent or treat osteoarthritis (OA).

The method targets 15-hydroxyprostaglandin dehydrogenase (15-PGDH), an age-related enzyme—or "gerozyme"—that accumulates in aging tissues and drives degeneration.

In aged mice, small-molecule inhibitors of 15-PGDH, delivered systemically or via intra-articular injection, promoted cartilage thickening and regeneration of functional hyaline articular cartilage.

This occurred without recruiting stem or progenitor cells; instead, existing chondrocytes underwent transcriptional reprogramming to a youthful state, with reduced populations of inflammatory and hypertrophic/degradative cells and expanded matrix-producing articular chondrocytes.

The inhibitors also reversed natural age-related cartilage thinning, improved joint function, and—when administered after simulated ACL injuries—strongly mitigated post-traumatic OA progression and associated pain.

Human OA cartilage explants from total knee replacements responded similarly in vitro, showing decreased degradation markers and evidence of new articular cartilage formation.

Given that an oral 15-PGDH inhibitor has already completed Phase 1 safety trials for age-related muscle atrophy, the findings open a path toward disease-modifying, regenerative therapies that could delay or obviate the need for joint replacement surgery.

[Agarwal, P., Su, S., Ancel, S., et al. (2025). Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration. Science. DOI: 10.1126/science.adx6649]

[peterbritz @bpeterb]

Verse by verse , it is written . ..

[The Biblical Man @Biblicalman]

Wrote this today.

A Bible note for the Christians who refuse cowardice
and refuse bloodlust.

When evil comes to the door, the Bible has a word.

https://t.co/R5tXWcxqEt

[peterbritz @bpeterb]

No Jesus , know pain

[peterbritz @bpeterb]

No Jesus , know pain.

[peterbritz @bpeterb]

120 yrs after ‘ Scorched Earth ‘ in South Africa , Islam is doing the the same to Britain. No women and children put into concentration camps after homesteads were burnt down , but their industrial / societal version of terrorism. No Jesus , know pain .

experiencing the

[Elon Musk @elonmusk]

Those who knew must go to prison for a long time

[peterbritz @bpeterb]

Exactomundo

[Volkstaat @Volkstaat10]

Written by someone else but very well said...

South Africans keep asking how much worse things can get.

That is the wrong question.

The question is what happens when decline becomes permanent.

For more than thirty years we have adapted to failure.

When electricity failed, we adapted.

When policing failed, we adapted.

When municipalities failed, we adapted.

When water systems failed, we adapted.

When roads deteriorated, we adapted.

When corruption was exposed, we adapted.

Every crisis became another inconvenience to work around.

Every failure became another expense.

Every expense became another sacrifice.

What we call resilience today would have been considered unacceptable twenty years ago.

The danger is not the collapse of institutions.

The danger is the collapse of expectations.

South Africans no longer expect functioning municipalities.

South Africans no longer expect reliable electricity.

South Africans no longer expect effective policing.

South Africans no longer expect government accountability.

We expect failure and then congratulate ourselves for surviving it.

That is not resilience.

That is surrender disguised as resilience.

The average South African is now paying to replace functions that government was created to provide.

Private security.

Solar systems.

Generators.

Water tanks.

Boreholes.

Medical aid.

Private education.

Armed response.

Tracking systems.

Insurance products designed around government failure.

Every year more responsibility moves to the citizen.

Every year more authority remains with the state.

That is the imbalance nobody is discussing.

A citizen who spends most of his income defending himself from decline is not building a future.

He is preserving the present.

His children inherit the same burden.

Then their children inherit it again.

Eventually an entire generation grows up believing this is simply how a country operates.

That is the true danger.

Not that South Africa collapses tomorrow.

Not that there is some dramatic event on the horizon.

But that decline becomes institutionalised.

Permanent.

Accepted.

Normal.

History shows that societies rarely lose their freedoms all at once.

They lose them gradually as independence becomes more expensive and dependence becomes more necessary.

The question South Africans should be asking is not whether the country is getting worse.

The evidence already answers that.

The question is this:

At what point does survival stop being resilience and start becoming acceptance?

Because once a nation accepts deterioration as normal, the battle is no longer against corruption, crime, failing infrastructure or incompetent governance.

The battle is against the belief that nothing better is possible.

And that is the moment decline stops being temporary and becomes a way of life.

Written by Shaun Schutte
14 June 2026”

[peterbritz @bpeterb]

💥

[peterbritz @bpeterb]

Believers be like …

[peterbritz @bpeterb]

Rom12:2 - And do not be conform to this world, but be transformed by the renewing of your mind, that you may prove what is that good and acceptable and perfect will of God.

[peterbritz @bpeterb]

Prov 6:6——8

[Shellie Bean @mag1ckbeans]

@Rainmaker1973 They’re amazing. If you’re into ants, you might like to save this photo. I didn’t take it and would gladly give credit to its author if I knew their name. If it matters to you, please sign your artwork and TYVM for sharing.💐

[peterbritz @bpeterb]

Prov 30:24-22
Prov 6:6—8

[Massimo @Rainmaker1973]

No other species on Earth has a teamwork system quite like ants.

[peterbritz @bpeterb]

1 Peter 5:8-9 …

[Tevin Macharia Mukabana @TevinMacharia]

Ronald Reagan: "We are never defeated unless we give up on God."

[peterbritz @bpeterb]

Good advice …

[peterbritz @bpeterb]

Let that sink in …

[Ben Casselman @ben2know]

This should speak to all of us…

[peterbritz @bpeterb]

3 John 1:4

[The Bible @The__Bible7]

3 John 1:4

[peterbritz @bpeterb]

Col3:23

[peterbritz @bpeterb]

It is written …

[Danny @Truth_matters20]

"Do not love the world or the things in the world. If anyone loves the world, the love of the Father is not in him." —1 John 2:15

[peterbritz @bpeterb]

Even though it might seem to others that He is silent …