TDP-43 aggregation drives neurodegeneration in ALS, FTD, and AD. Short RNA chaperones can solubilize TDP-43 and restore nuclear function, offering therapeutic potential, though key mechanistic and translational hurdles remain. https://t.co/nbgTRnXK6s
Alzheimer’s disease is linked to brain hyperglycosylation driven by increased glycan synthesis. Reducing glycan biosynthesis improves cognition in AD mice, while glucosamine worsens outcomes, identifying glycan metabolism as a therapeutic target. https://t.co/jjlqgYPxKz
Spatial transcriptomics identified six serotonergic subpopulations in the dorsal raphe nucleus and revealed acute/chronic fluoxetine-induced gene changes, including Htr1a regulation, signaling pathways, and neuropeptide expression. https://t.co/uFR4Adrq1U
Young brains preserved memory after AβO exposure, whereas aging brains showed reduced resilience. Age and AβO exerted additive and region-specific synergistic effects, highlighting the importance of aging in preclinical AD models. https://t.co/3qHTIiLXn7
A genetic tracing system reveals compartmentalized brain protein-clearance routes to CSF and border tissues. Drainage follows a “nearest exit” rule, while inflammation and amyloid pathology disrupt clearance through distinct mechanisms. https://t.co/TjRkI0Gbli
Plasma-based staging may provide a scalable, minimally invasive approach to biological stratification of Alzheimer disease, with potential value for treatment selection and clinical trial enrichment. https://t.co/T2L5LihlFO
An optogenetic model of accelerated TMS-like stimulation produced rapid antidepressant effects by enhancing prefrontal synaptic plasticity and activating a fronto-insular circuit. Human EEG/fMRI data confirmed this network as a key mediator. https://t.co/u6DDz5LzCc
Direct recordings from the human thalamus revealed a novel 19–45 Hz oscillation present only during wakefulness and REM sleep. This signal, localized to the central thalamus, tracks REM microstates and may help regulate conscious brain states. https://t.co/CAq3ITfPkh
This retrospective study found that adult status epilepticus mortality has risen over 2 decades, highest in elderly and non-Hispanic Black adults: https://t.co/iLqN51iRo2
Recent studies have revealed the synchronization of neuromodulators including norepinephrine, serotonin, acetylcholine, dopamine, and histamine during sleep.
A new #ScienceReview explores what potential role the synchronization of these oscillations may play in health. https://t.co/fcDdHm1SDP
Researchers identified inhibitory neurons linking the Rostral Ventromedial Medulla to the spinal cord that mediate “pain-inhibits-pain” effects, suppress widespread pain sensitivity, and may malfunction in chronic pain syndromes. https://t.co/3sSexRn217
Neuroligin-2 is essential for inhibitory plasticity in the hippocampus and its consolidation after induction. Disrupting neuroligin-2 erases inhibitory, but not excitatory, plasticity, with implications for epilepsy, autism, and schizophrenia. https://t.co/fRbxlv3WDg