Researching the Brain

Sharing brain research articles with today's most significant findings.

[Researching the Brain @Brain_Database]

Fructose weakly suppresses hypothalamic AgRP hunger neurons compared with glucose. It signals through a distinct gut–brain PYY/Y2R vagal pathway, shaping food preference without affecting short-term intake and revealing nutrient-specific AgRP responses. https://t.co/p0WTil8iyl

[Researching the Brain @Brain_Database]

TDP-43 aggregation drives neurodegeneration in ALS, FTD, and AD. Short RNA chaperones can solubilize TDP-43 and restore nuclear function, offering therapeutic potential, though key mechanistic and translational hurdles remain. https://t.co/nbgTRnXK6s

[Researching the Brain @Brain_Database]

Alzheimer’s disease is linked to brain hyperglycosylation driven by increased glycan synthesis. Reducing glycan biosynthesis improves cognition in AD mice, while glucosamine worsens outcomes, identifying glycan metabolism as a therapeutic target. https://t.co/jjlqgYPxKz

[Molecular Neurodegeneration @MolNeuro]

Longitudinal multiphoton imaging of #CerebralAmyloidAngiopathy in response to anti-#ApoE4 #immunotherapy in mice

Orla Bonnar, Fareeha Saadi, Maria V. Sanchez-Mico...Susanne J. van Veluw @harvardmed @UKDRI @washumedicine #AlzheimersDisease

https://t.co/bhe8Cl2j2S

[Researching the Brain @Brain_Database]

Spatial transcriptomics revealed six serotonergic subpopulations in the dorsal raphe. Fluoxetine induced distinct acute and chronic gene-expression changes, affecting Htr1a, Ras/MAPK/cAMP signaling, axon guidance, and neuropeptides. https://t.co/uFR4Adrq1U

[Researching the Brain @Brain_Database]

Liraglutide exerts antidepressant effects independently of GLP-1R via a gut–brain mechanism. It increases Lactobacillus delbrueckii, restores endocannabinoid 2-AG levels, normalizes neuronal activity, and alleviates depression-like behaviors. https://t.co/JnKomhPboN

[Researching the Brain @Brain_Database]

Home alone: Remote work, isolation, and mental health | Science https://t.co/UwhJEndNAB

[Researching the Brain @Brain_Database]

Spatial transcriptomics identified six serotonergic subpopulations in the dorsal raphe nucleus and revealed acute/chronic fluoxetine-induced gene changes, including Htr1a regulation, signaling pathways, and neuropeptide expression. https://t.co/uFR4Adrq1U

[Researching the Brain @Brain_Database]

Young brains preserved memory after AβO exposure, whereas aging brains showed reduced resilience. Age and AβO exerted additive and region-specific synergistic effects, highlighting the importance of aging in preclinical AD models. https://t.co/3qHTIiLXn7

[Researching the Brain @Brain_Database]

Sleep may have a unique role in vascular brain health and dementia risk https://t.co/K6Iu4sBviz

[eLife - the journal @eLife]

The nucleus accumbens shell regulates hedonic feeding via a rostral hotspot
https://t.co/RJ0fKdsx5X

[Researching the Brain @Brain_Database]

The oscillatory biology of sleep: Linkage to dementia | Science https://t.co/6Gm3dEXhTB

[Researching the Brain @Brain_Database]

A genetic tracing system reveals compartmentalized brain protein-clearance routes to CSF and border tissues. Drainage follows a “nearest exit” rule, while inflammation and amyloid pathology disrupt clearance through distinct mechanisms. https://t.co/TjRkI0Gbli

[Researching the Brain @Brain_Database]

Plasma-based staging may provide a scalable, minimally invasive approach to biological stratification of Alzheimer disease, with potential value for treatment selection and clinical trial enrichment. https://t.co/T2L5LihlFO

[Researching the Brain @Brain_Database]

An optogenetic model of accelerated TMS-like stimulation produced rapid antidepressant effects by enhancing prefrontal synaptic plasticity and activating a fronto-insular circuit. Human EEG/fMRI data confirmed this network as a key mediator. https://t.co/u6DDz5LzCc

[Researching the Brain @Brain_Database]

Direct recordings from the human thalamus revealed a novel 19–45 Hz oscillation present only during wakefulness and REM sleep. This signal, localized to the central thalamus, tracks REM microstates and may help regulate conscious brain states. https://t.co/CAq3ITfPkh

[Neurology Journal @GreenJournal]

This retrospective study found that adult status epilepticus mortality has risen over 2 decades, highest in elderly and non-Hispanic Black adults: https://t.co/iLqN51iRo2

[Science Magazine @ScienceMagazine]

Recent studies have revealed the synchronization of neuromodulators including norepinephrine, serotonin, acetylcholine, dopamine, and histamine during sleep.

A new #ScienceReview explores what potential role the synchronization of these oscillations may play in health. https://t.co/fcDdHm1SDP

[Researching the Brain @Brain_Database]

Researchers identified inhibitory neurons linking the Rostral Ventromedial Medulla to the spinal cord that mediate “pain-inhibits-pain” effects, suppress widespread pain sensitivity, and may malfunction in chronic pain syndromes. https://t.co/3sSexRn217

[Researching the Brain @Brain_Database]

Neuroligin-2 is essential for inhibitory plasticity in the hippocampus and its consolidation after induction. Disrupting neuroligin-2 erases inhibitory, but not excitatory, plasticity, with implications for epilepsy, autism, and schizophrenia. https://t.co/fRbxlv3WDg