Krzysztof Potempa

Founder & CEO @BRAINCURESLtd and dreamster dedicated to prevention and treatment of mental health disorders that affect at least 1 in 6 people worldwide

[Krzysztof Potempa @BRAINCURES]

🧵 Rob Burrow @Rob7Burrow's CBE, Amyotrophic Lateral Sclerosis, also known as Lou Gehrig’s/MND, story in headlines continues beyond his premature death on 2 June 2024. Help advance treatments for ALS by supporting @BraincuresLTD's crowdfunding @JustGiving https://t.co/XF8Y37ctLQ

[Krzysztof Potempa @BRAINCURES]

🧵Women’s health companies are now changing their investment pitches. The addressable market they’re chasing is bigger, involving depression, obesity or heart disease that affect both women & men—but impact women differently, disproportionately or uniquely
https://t.co/zeQEDUIAiy

[Krzysztof Potempa @BRAINCURES]

By and large, biotech sector’s top investors have shifted their sights to more ready-made drug prospects. They’re more reticent to join seed rounds, leading @MassBio to warn that its “biggest concern” is the “earliest startups with the riskiest science.”
https://t.co/OZcaNFhKe0

[Krzysztof Potempa @BRAINCURES]

🧵 Well-known academics with gee-whiz technology are still funded, many of them spawning half-a-dozen or more companies. But for walk-in entrepreneurs with truly novel ideas looking for venture seed capital (say under $5 million), it is a challenging time
https://t.co/E3KINm2RpS

[Krzysztof Potempa @BRAINCURES]

“Can it go from amazing idea to drug candidate in 12–24 months, for $5–15 million, and, after that, to industry-quality clinical data for a further $35–70 million?”. If yes, “we’ll help founders further that idea, wherever they are in the world” @Curie_Bio
https://t.co/WuNAdw8WDh

[Krzysztof Potempa @BRAINCURES]

The worst part isn't the academic bullying. It's the cover-up. Report it and you learn how fast an institution closes ranks. HR works for the employer. The internal ombudsperson reports to the same rector. The people "looking into it" are the bully's peers
https://t.co/x24rkVDUK7

[Krzysztof Potempa @BRAINCURES]

🧵 Universities must stop protecting bullies by Morteza Mahmoudi @MoriMahmoudi, founder of Academic Parity @AcademicParity Movement
https://t.co/NsaGDWTKlm

[Krzysztof Potempa @BRAINCURES]

🧵 Resources for mid-career scientists. What is the mid-career stage in science and how can scientists prepare for it? Funders and governing body representatives join researchers who have reached this stage in their working lives to share advice & insights
https://t.co/WUpNY58KAj

[Krzysztof Potempa @BRAINCURES]

🧵 Careers advice from scientists in industry. Scientific careers in industry range from jobs at multinational technology and life-sciences companies employing tens of thousands of people to positions at one-person start-ups spun off from universities
https://t.co/NPGAvokEjb

[Krzysztof Potempa @BRAINCURES]

Outside of China, other Asian biotech hubs have early ambitions, too. Back to School 2026: Korea, Taiwan, and Singapore seek earlier roles in global development, while Japan removes barriers to joining global trials @BioCentury
https://t.co/0AedHSyyCF

[Krzysztof Potempa @BRAINCURES]

🧵The growth of biotech hubs outside of the top 10 regions and states ranked since 2014 in GEN’s nationally- and regionally-cited top 10 clusters A-List has sparked a question among readers: What are the next up-and-coming hubs for life sciences activity?
https://t.co/kPavrUIuUp

[Krzysztof Potempa @BRAINCURES]

The story of @JebBush's attempt to build a cluster is pertinent today given the establishment of biotech ecosystems and the high-paying jobs they create remains a dream for governments. Officials in the United Kingdom are trying to build their own clusters
https://t.co/YaNHl9wfYB

[Krzysztof Potempa @BRAINCURES]

Subramanian et al previously piloted the concept of a Connectivity Map (CMap), whereby genes, drugs, and disease states are connected by virtue of common gene-expression signatures. Below, they report more than a 1,000-fold scale-up of the CMap as part of the NIH LINCS Consortium

[Krzysztof Potempa @BRAINCURES]

@BraincuresLTD @Francesco_i0ri0 @Pseudoenzyme @AndrewJDoig1 @TimGuilliams @ChristineJMcN @cavallad @MPUoL @hmpharmacon @AnticancerOrgUK @LoriFerrins @DavidFajgenbaum @findacure_fdn @M4RareDiseases @camraredisease @FeixiongCheng @Rishidesai11 @barabasi @ParisiDan @kshameer @cuypersb @ierrejon @BU_CNIO @PeralesPaton @jonaslindeloev @wolfgangkhuber @M_Rigau @jonirutter @PardisSabeti @AlexandraKeenan @AjayPMD @sobielab @AviMaayan @BD2KLINCSDCIC @CliveSvendsen @CellSystemsCP @LINCSProgram @NIH A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles based on
25,200 unique perturbagens that include:
1⃣19,811 compounds
2⃣5,075 genes targeted by shRNA cDNA
3⃣314 biologics

https://t.co/cXavc4XYgh

#L1000 #Genomics #ML #DataScience #Biotech #RRI

[Krzysztof Potempa @BRAINCURES]

🧵 The LINCS L1000 project was an excellent resource that researchers could access through the https://t.co/HqYB0VZJ5l site. However, on January 31, 2026 the website and tools associated with it were retired due to financial constraints. @NIH please revive these resources

[Ming "Tommy" Tang @tangming2005]

The LINCS L1000 project has collected gene expression profiles for thousands of perturbagens at a variety of time points, doses, and cell lines https://t.co/8qOcXtHyc4

[Krzysztof Potempa @BRAINCURES]

Since its first introduction in 2006, the cMap/L1000 approach has shown emerging promises in uncovering avenues for drug discovery and development such as in identifying and suggesting new indications for existing drugs and elucidating mode of actions for novel chemicals

[Krzysztof Potempa @BRAINCURES]

@Francesco_i0ri0 @Pseudoenzyme @AndrewJDoig1 @ChristineJMcN @MPUoL @hmpharmacon @AnticancerOrgUK @LoriFerrins @findacure_fdn @M4RareDiseases @camraredisease @Rishidesai11 @barabasi @ParisiDan @kshameer @cuypersb @ierrejon @BU_CNIO @PeralesPaton @jonaslindeloev @wolfgangkhuber @M_Rigau @jonirutter @PardisSabeti @AlexandraKeenan @AjayPMD @sobielab @CliveSvendsen @LINCSProgram @bangwong @lhgstm @corsellos @neuro_mgh @SchreiberStuart @A_Lizee @LeoBman @iDrDex @KewalinSamart @BD2KLINCSDCIC @NIH_CommonFund @blucher_a @omendezlucio @Muhamma51714245 @Supergecko @ollie_pain @ChiaraFabbri12 @cathrynlewis @pa_agarwal @GenomeMedicine The Connectivity Map concept and process allows for a list of candidate therapeutics or potential phenotype inducers to be identified based on the interpretation of the phenotypic screening scores obtained report Xiaoyan Qu & Deepak Rajpal

https://t.co/ayPLC8yQ8x

#RRI #Genomics

[Krzysztof Potempa @BRAINCURES]

"The elite universities like Cambridge and Oxford had a particular problem because they are perceived to be quite harsh places, quite unkind places and very white places. And they wanted to change that impression" says @kathleen_stock1 who resigned in 2021
https://t.co/zZdGTZzNDd

[Krzysztof Potempa @BRAINCURES]

🧵Jason Arday, the former @Cambridge_Uni professor at the centre of a plagiarism row, has been found dead. He resigned as a Cambridge professor of sociology of education last week after allegations of plagiarism and questions about some of his achievements
https://t.co/yO3HVaivfW

[Krzysztof Potempa @BRAINCURES]

Newspapers dissected Professor Arday's previous work while at Durham and Glasgow universities, and on social media, academics were divided between those publicly championing the black autistic academic and those who said his work did not withstand analysis
https://t.co/6ZkYZOoBUF