Dr. Lee Schwamm

SVP/Chief Digital Health Officer @YNHHealth + Assoc Dean, Digital Strategy & TX @YaleMed + MD @StrokeAHA_ASA = Digital Transformation to Democratize Healthcare

[Dr. Lee Schwamm @Braindoc_MGH]

Great time speaking with my good friends and colleagues @hmkyale and @thehowie on their podcast Health Veritas about how we are vetting and implementing AI and digital transformation at Yale School of Medicine and the Yale New Haven Health System.
https://t.co/UUugjUjRYS

[Dr. Lee Schwamm @Braindoc_MGH]

Join us May 26 @ynhhealth Health AI Symposium. World-class national leaders in conversation about where the rubber meets the road in actual health AI implementation. Real world problems solved by real world innovators for real world patients. Register @
https://t.co/2W6KtJ63O7

[Dr. Lee Schwamm @Braindoc_MGH]

Amazing program to build AI tools that can help address disparities in access to expert care. Encoding expertise for on demand knowledge delivery at lower cost.

[Dr. Lee Schwamm @Braindoc_MGH]

Excited to be at Yale @YaleMed Medical AI Symposium and hearing from Dean Nancy Brown and Susan Gregurick, Ph.D. From @NIH on the various programmatic elements to support translational medical AI.

[Dr. Lee Schwamm @Braindoc_MGH]

From evidence to guidelines to practice is what AHA does best!
@AHAScience

[AHA Science @AHAScience]

📢Hot topic at #ISC26: 2026 AIS Guideline

Key updates to this guideline include the incorporation of new evidence related to thrombolytic choice and eligibility, determination of eligibility for endovascular thrombectomy,

Mobile stroke units enable rapid identification and treatment of thrombolytic-eligible patients with acute ischemic stroke.

@BraydonDymm

[Dr. Lee Schwamm @Braindoc_MGH]

Loberamisal trial in moderate AIS <48h, ~1000 pts in <1 yr from the amazing Tiantan Hospital group shows this PSD95 Inhibitor led to substantial 13% improvement at 90d without safety concerns! Wow!!! Validate in addl populations!

#ISC26 @AHAScience

[Dr. Lee Schwamm @Braindoc_MGH]

Parent reports big improvements in fine motor activity though of course parents unblinded.

[Dr. Lee Schwamm @Braindoc_MGH]

I-ACQUIRE RCT highly novel trial of constraint therapy for infants with perinatal ischemic stroke to improve CO outcomes. Major enduring improvements for hi dose RX but did hit primary outcome and mod dose = usual care.
#ISC26 @AHAScience

[Dr. Lee Schwamm @Braindoc_MGH]

@ShadiYaghi2 @elghanemmoh @Ash_Shoamanesh Is the next trial DOAC + ASA vs DOAC + FXIa for patients who need intensification beyond DOAC alone? Or low dose DOAC + FXIa for patients who need anticoagulants but have increased risk of bleeding? Exciting!

[Dr. Lee Schwamm @Braindoc_MGH]

@almuftifawaz @dyavagal @BayerPharma @AliciaCastongu2 @NguyenThanhMD @NuroseKarim @ShadiYaghi2 @ChaiLatteMD @hariskamalmd @kaurgurmeen A whole new class of antithrombotic agents is a MAJOR game changer for cerebrovascular care. An antithrombotic that doesn’t increase hemorrhage: have we found the Holy Grail?

[Dr. Lee Schwamm @Braindoc_MGH]

Stroke Council Award recipient @PoojaKhatriMD breaking down silos in her great talk. No one knows better than Pooja and StrokeNet investigators that Stroke is a Team Sport! From bench to bedside to community living and back!

[Dr. Lee Schwamm @Braindoc_MGH]

The quest for optimal stroke prevention by the ever diligent and detailed @ChaturvediNeuro as the David Sherman award. Sometimes when faced with a surgical procedure for asymptomatic disease, the best advice is paradoxically, ”Don’t do something, just stand there!” @AHAScience

[Dr. Lee Schwamm @Braindoc_MGH]

One of the best quotes on mentorship I’ve seen

[Dr. Lee Schwamm @Braindoc_MGH]

Inspiring talk from Ralph Sacco mentor award recipient Kazunori Toyoda on the history of his work implementing stroke research and systems of care in Japan and the contributions of his many mentees!
Outsized impact is all about systems and networks
#ISC26 @AHAScience

[Dr. Lee Schwamm @Braindoc_MGH]

FASTEST trial F rVIIa for pts age 18-80, small volume of ICH and IVH and use of MSUs. Overall no change in outcomes with Rx but strong evidence of biological effect with <hematoma growth. Spot Sign and treatment <90 mins promising. Watch for phase 2 results! #ISC26 @AHAScience

[Dr. Lee Schwamm @Braindoc_MGH]

CHOISE-2 primary outcome shows better outcomes with post -EVT IA atleplase as a cleanup for improved microvascular perfusion, despite higher mortality. No subgroups showed differential outcomes. Highly impactful and well designed RCT!

[Dr. Lee Schwamm @Braindoc_MGH]

@PoojaKhatriMD honored at #ISC26 @AHAScience with the Feinberg Award for her decades of contributions to improving stroke science and outcomes. Great and humble leader and newly appointed Chair of Neurology @YaleMed. A distinguished career recognized by her peers!

[Dr. Lee Schwamm @Braindoc_MGH]

Massive and so well deserved recognition for the leadership, wisdom and guidance provided by Dr. Walter Koroshetz as a decade as Director of NINDS here at #ISC26 @AHAScience. Mentor to many, friend to all interested in neuroscience, and one of my personal heroes.

[Dr. Lee Schwamm @Braindoc_MGH]

AI thoughts w/@SnehaShahJain in Science Advisory on Pragmatic Approaches to AI in Health Care https://t.co/8PtXBKj1hI, w/+ @hmkyale Perspectives on Meaningful AI Research in CV Care https://t.co/PlDBrwQHK2 + @YaleMed @rohan_khera Dr. Ohno-Machado https://t.co/4q3c5RxixO.

[Dr. Lee Schwamm @Braindoc_MGH]

Let's talk about the nuts and bolts of implementing AI in real world settings. See this interview just posted for some of my thoughts and welcome your candid feedback!
Making AI Guidance a Part of Digital Health Governance https://t.co/RuJ3XJTnMS