Brian R Wamhoff

Biotech Executive | Drug Discovery Innovator | Entrepreneur | Organizational Developer | Patient Advocate | Board Advisor

[Carnegie Mellon Football @TartanFB]

We are very proud of @JohnNorell for donating to @nmdp_org through @TalleyBoneMarro! Way to lead from the front and help save a life!

#CODE #BYB #TartanProud

[Millie Marconi @MillieMarconnni]

Holy shit...Stanford just built a system that converts research papers into working AI agents.

It’s called Paper2Agent, and it literally:

• Recreates the method in the paper
• Applies it to your own dataset
• Answers questions like the author

This changes how we do science forever.

Let me explain ↓

[Rohan Paul @rohanpaul_ai]

New Stanford + SambaNova + UC Berkeley paper proposes quite a revolutionary idea. 🤯

Proves LLMs can be improved by purely changing the input context, instead of changing weights.

Introduces a new method called Agentic Context Engineering (ACE).

It helps language models improve by updating what they read and remember, instead of changing their core weights.

It has three parts: a Generator that works on tasks, a Reflector that learns from mistakes, and a Curator that updates the notebook with helpful lessons.

So ACE works like this. The model first tries to solve a task. While doing that, it writes down its reasoning steps, which show what helped and what caused mistakes.

That record is passed to another model, called the Reflector. The Reflector reads it and writes short lessons based on it, such as useful tricks, common errors, or patterns that worked better.

Then another component, the Curator, takes these lessons and turns them into small, clearly written notes called delta items. These are merged into the existing playbook using simple rules. The system does not rewrite the whole context, it only adds or edits these tiny pieces.

Because of this, it keeps all the useful older notes while gradually improving the context with every new task. Over time, the playbook becomes a stronger, richer guide that helps the model perform better on future tasks without retraining or changing weights.

This design avoids full rewrites that can trigger “context collapse”, where a long, useful context shrinks and accuracy drops. Instead, the context grows steadily and stays specific to the domain.

🧵 Read on 👇

[Brian R Wamhoff @Brian_Wamhoff]

Proud to be a small part of this year’s kickoff as parents of @MarkWamhoff - we are thrilled about the upcoming season - Go Tartans, good luck gentlemen!

[Carnegie Mellon Football @TartanFB]

Kicking off the 2025 season right with over 340 Tartan Family Members!!

#CODE #BYB #TartanProud

[Brian R Wamhoff @Brian_Wamhoff]

RJ is one of the hardest workers you’ll ever coach. Proud of you RJ and grateful for your relationship with @MarkWamhoff - love watching you guys spin it!

[C'ville Varsity @CvilleVarsity]

This week's @AugustaHealthVA Athlete Spotlight is on @WAHSWarriors receiver RJ Corbey, who leads by example both on and off the field.
“He keeps some very good company around him that he brings along in attempts to make everyone around him better.” https://t.co/VsUsVSZhO8

[Marshall Summar, M.D. @genedocrare]

@davidrliu @US_FDA It is incredibly uplifting and joyful to see this work. I worked on the urea cycle for close to 40 years and my work focused on the CPSI gene and its sequence and mutations. For all of those patients who have been waiting so long for something like this, I send my best wishes.

[C'ville Varsity @CvilleVarsity]

“Every game we play, no matter what seed, we come to play.”
The @CovenantEagles girls lacrosse team defeats North Cross to win its fourth straight Blue Ridge Athletic Conference championship. https://t.co/4hZQ8kXhxJ

[Mark Wamhoff @MarkWamhoff]

Roll Tarts! @CoachRyanLarsen @CoachAndyHelms @TartanFB

[Marshall Summar, M.D. @genedocrare]

https://t.co/RvHWVR9Rdm

[Brian R Wamhoff @Brian_Wamhoff]

Congratulations to you and the team! We proud of you guys!

[Mark Wamhoff @MarkWamhoff]

I couldn't have asked for a better group of guys to play with this year. We completed the first undefeated season at Woodberry since 2000! Incredibly grateful to have earned the Offensive MVP award. #earnednotgiven #FIDO

Senior Season Highlights ⬇️:
https://t.co/H2r5YdUGYM

[Mark Wamhoff @MarkWamhoff]

I couldn't have asked for a better group of guys to play with this year. We completed the first undefeated season at Woodberry since 2000! Incredibly grateful to have earned the Offensive MVP award. #earnednotgiven #FIDO

Senior Season Highlights ⬇️:
https://t.co/H2r5YdUGYM

[Marshall Summar, M.D. @genedocrare]

Take a look at our thought piece about why it's a good time to invest in rare disease. https://t.co/mrqtEgvuhc

[Brian R Wamhoff @Brian_Wamhoff]

@MarkWamhoff @CoachRyanLarsen @CoachAndyHelms @TartanFB @WoodberryFB @Coach_Brady @Get__Recruited @Spotlight39_Pod We are so very proud of you, Mark!

[Mark Wamhoff @MarkWamhoff]

Huge comeback win this past weekend against Trinity Episcopal (34-28). Earned not given❗️
@CoachMatteo_WFS @ConnorJessop @Coach_Brady @WoodberryFB

Highlights below ⬇️: https://t.co/zHxA8dTTHm

[Mark Wamhoff @MarkWamhoff]

It felt great to kickoff the season with a big win on the road at Flint Hill this past weekend! Just the start, onto the next.
@WoodberryFB @CoachMatteo_WFS @ConnorJessop @Coach_Brady

Highlights below ⬇️: https://t.co/qVaxFGr2wD

[Brian R Wamhoff @Brian_Wamhoff]

Proud of you, Mark! Keep
Pushing, will be a fun season. Pops.

[Mark Wamhoff @MarkWamhoff]

After an amazing visit and conversation with @CoachRyanLarsen, I’m blessed to have received an offer from Carnegie Mellon University❗️
@CoachAndyHelms @Coach_Kay19 @coachfloppy @CoachMatteo_WFS @Coach_Brady

[Matthew Herper @matthewherper]

J.D. Vance’s health care policy views, VC investment https://t.co/RFf1entj5h

[Mark Wamhoff @MarkWamhoff]

After a great call with @MiddFBMandigo, I’m blessed to have a received an offer from Middlebury College❗️
@FBCoachPaquette @jasonthomasfb @Coach_Brady @CoachMatteo_WFS @ConnorJessop

[Mark Wamhoff @MarkWamhoff]

Thank you to the entire @CULionsFB coaching staff for making camp this morning an amazing experience. Had a great time working with @SSmith_II and all the other QB’s. Ran two sub-7 times on the three cone drill (6.85, 6.72).
@CoachT_82 @Coach_Poppe @Coach_Batti @CoachMatteo_WFS

[Mark Wamhoff @MarkWamhoff]

Had a great experience up in New Haven for the @yalefootball camp today. Thank you @CoachOstrowsky & @CoachCiotti11 for the opportunity to compete and learn!
@CoachRenoYale @jasonthomasfb @CoachHorvatits @CoachSDwyer @CoachCerf