Margaret Brimble

Medicinal chemistry molecule maker! Mother of Trofinetide/NNZ2566 FDA approved drug for Rett Syndrome tradename Daybue - Neuren/Acadia Pharmaceuticals

[Margaret Brimble @BrimbleM]

@melindacapecod @AcadiaPharma Wow - I have been away from X for ages then when I looked I saw this. What a transformation Katelin!!

[Margaret Brimble @BrimbleM]

@BrittonLab @DrLCsquare @J_A_C_S Nice to see @Marzieh_Ahangar looking happy.

[Kokotos CG Research Group @KokotosCG]

Check out this great opportunity for visiting Lodz! Lukacz Albercht and the organizing committee have made an excellent job!!!
https://t.co/IpQ1c5UiOz

[Hans Renata @hanzyduzit]

I often think about the parallels of total synthesis and the many disappearing crafts around the world (e.g., bespoke tailoring, batik tulis, Indian Rogan painting), including being abandoned for alternatives with faster gratification, and it makes me sad https://t.co/vdrQ2G79h5

[Margaret Brimble @BrimbleM]

Wow looks like so much fun. Katelin is going from strength to strength. Give her a hug from me!

[melinda @melindacapecod]

@BrimbleM
Had so much fun at the biochemical/chemical science fair! She did great helping with the experiments. She kept her hat on all day at the zoo except when we were in the shade.First time ever❤️ plus, I bragged about you a bit 😉 and one guy pulled you up, right then and there!
#Rettsyndrome #Daybue @AcadiaPharma

[Rett Dad @RettDad]

Study reveals that Daybue shows real-world benefits for Rett patients https://t.co/9YIOGVX3PO

[Margaret Brimble @BrimbleM]

Super proud of Dr Jamie-Lee Rahiri ⁦@AucklandUni⁩ ⁦@FMHS_UoA⁩ winner of 2025 ⁦@LOrealAUNZ⁩ women of science award for NZ following in footsteps of ⁦@dr_matire⁩ nice haka from her husband

[Margaret Brimble @BrimbleM]

Nice work from PhD student Yongqi (Crystal) Lin! Crystal has a bright future ahead of her!

[Total Synthesis @TotalSynthesis]

Asymmetric #TotalSynthesis of (+)-Spiroapplanatumine G by Yongqi Lin, Freda F. Li, and Margaret A. Brimble @BrimbleM @Brimble_Lab in @JOC_OL https://t.co/g3PDq9uoCU

[Margaret Brimble @BrimbleM]

Wonderful to see organic chemistry ⁦@LOrealAUNZ⁩ #Maisonloreal beautiful event tonight. Thanks for supporting women in science through L’Oreal UNESCO #FWIS programme

[Margaret Brimble @BrimbleM]

Wonderful story - I even remember the day we made NNZ2566 in the lab and NNZ2591 has an interesting back story!

[Thor Asgard @Thor___Asgard]

@PCarioli A small, early-stage Australian biotech, which was worth only a few million dollars, has managed to launch a U.S. Phase 3 trial all on its own!!!!! Thanks to the success of NNZ-2566 that generated cash for them, sure, but how many actually pull that off??? Impressive!!!

[Margaret Brimble @BrimbleM]

Sorry I didn’t make it! Looks like fun.

[Kozlowski Lab @KozlowskiMarisa]

Kalyana (G4, @KalyanaDuggal) attending the 2025 Organic Reactions and Processes @GordonConf at @BryantUniv!

[Margaret Brimble @BrimbleM]

Wonderful news for a formidable team! Congratulations and thanks for the warm hospitality last week. Your science is first class.

[John E. Moses @HarborSpring]

More good funding news! We’ve been awarded a NIH UG3 grant with the Tuveson Lab for a project combining click chemistry + natural products to block KLK6 and prevent early pancreatic cancer. Grateful to NIH and all collaborators pushing this forward.

[Margaret Brimble @BrimbleM]

Nice to see @Marzieh_Ahangar enjoying herself. We miss you here!

[BrittonLab @BrittonLab]

We enjoyed an amazing BBQ outing yesterday at Strathcona Lookout Park in Deep Cove! The day was filled with fun on the water in paddle boards and canoes (thanks Rob!) along side some competitive spike ball games in the park :) #chemtwitter #teambonding

[Margaret Brimble @BrimbleM]

It was really lovely to see you again today. Please give my love to Katelin xxxxx

[melinda @melindacapecod]

It was such a pleasure to meet up with @BrimbleM and @BrimbleMark at @AcadiaPharma I learned more about the development of Trofinetide, which I hardly thought possible! Margaret is a true inspiration. Thank you to Acadia for the invite.

[Margaret Brimble @BrimbleM]

Enjoyed talking @AcadiaPharma about the medicinal chemistry behind the discovery of the FDA approved drug NNZ2566/trofinetide/Daybue to treat Rett Syndrome. The mosaic in the picture comprises photos of the patients on Rett Syndrome trials. @Neuren @AucklandUni @melindacapecod

[Rett Dad @RettDad]

This $1.3b biotech is still run out of a spare bedroom in Melbourne https://t.co/1m1ZYvuJLJ

[Rett Dad @RettDad]

Trofinetide improves behavioral, physical outcomes in Rett syndrome at 9 months https://t.co/npsJyp6Vmy

[Margaret Brimble @BrimbleM]

Thanks for submitting this beautiful work to @JOC_OL

[Krische Lab @KrischeLab]

Congrats to Dana on the formal synthesis of fostriecin! https://t.co/v6eD5RJ6PE

[Margaret Brimble @BrimbleM]

Di was a wonderful supporter & advocate for women in science. She supported me when I travelled to Paris for the L’Oreal-UNESCO women in science laureate awards. She continued to mentor me and many other scientists with empathy &understanding of the enormous challenges. RIP

[peter gluckman @PeterGluckman]

Saddened that Di McCarthy has passed away. she was my deputy dean with us was medical dean then CE of the Royal Society of NZ - a real enthusiast for science and a great friend. The last year has been very difficult for her but it is a great loss.

[Margaret Brimble @BrimbleM]

Thanks for choosing @JOC_OL to publish this nice work. Well done Andy and team.

[Andy Lawrence @biomimetic_chem]

Check out the first total synthesis of brevianamide S. Congratulations Adam and the whole team! Spoiler: We didn't follow a biomimetic approach...we opted for a more flexible three-component coupling strategy. https://t.co/IQ7B63P8ZD