bt

A woman who was written by a man, but that man was Philip K. Dick.

[Rob @whatisaging]

As a kid, I'd have feelings that the world should be interesting and supernatural, but reality would never match. I'd be drawn to fantasy novels to make up for it.

The 2020's are finally where things have gotten surprising. My inner kid is looking forward to what's next.

[The Sci-Tech Guy @theSciTechGuy]

🚨 Human Brain can solve hardest problems right before sleeping

Research indicates the brain reaches a "creative sweet spot" right before sleep, known as hypnagogia. In this twilight state between wakefulness and sleep, the brain connects unrelated concepts and generates insightful solutions

[Biff @Biffdon]

Obvious obviousness. Bryan Johnson faking an incurable disease so he can say he cured an incurable disease with some product he will pitch later on.

[Geiger Capital @Geiger_Capital]

The United States is 3 human lifetimes old.

That’s it. In those short years we invented the light bulb, the telephone, the airplane, the transistor and the internet. We turned a few wooded colonies into the most powerful nation in the history of the world.

[bt @bt57414527]

@allTheYud Get tested for non-classic adrenal hyperplasia: ACTH stimulation with 17-OHP.

[Master Metabolism @lowmegatron]

Grey hair is caused by stress-induced increases in noradrenaline, and it is reversible.

The video shows reversed greying from the plucked hair of a 30-year-old participant.

The mechanism, increasing stress hormones locally, mirrors that shown in fasting-induced hair loss research.

“Hair greying is a hallmark of aging generally believed to be irreversible and linked to psychological stress...

We show white/grey hairs that naturally regain pigmentation across sex, ethnicities, ages, and body regions, thereby quantitatively defining the reversibility of greying in humans...

We also report hair greying and reversal that can occur in parallel with psychological stressors...

Hair growth is an active process that happens under the skin inside hair follicles. It demands lots of energy, supplied by structures inside cells called mitochondria. While hairs are growing, cells receive chemical and electrical signals from inside the body, including stress hormones. It is possible that these exposures change proteins and other molecules laid down in the growing hair shaft...

“Anecdotal case reports and a recent pilot study suggest that psychological stress and other behavioral factors accelerate the hair greying process (Nahm et al., 2013; Peters et al., 2017), a notion supported by studies in mice demonstrating that adrenergic stimulation by norepinephrine signaling leads to melanocyte stem cell depletion in mice (Zhang et al., 2020). However, contrary to mice where this process appears to be irreversible at the single hair follicle level, our data demonstrates that human hair greying is, at least under some circumstances, reversible.

Examining single-hairs and matching the patterns to life events could allow researchers to look back in time through a person’s biological history...

This method revealed that some white hairs naturally regain their color, something that had not been reported in a cohort of healthy individuals before. Aligning the hair pigmentation patterns with recent reports of stress in the hair donors’ lives showed striking associations. When one donor reported an increase in stress, a hair lost its pigment. When the donor reported a reduction in stress, the same hair regained its pigment...

Rosenberg et al. mapped hundreds of proteins inside the hairs to show that white hairs contained more proteins linked to mitochondria and energy use. This suggests that metabolism and mitochondria may play a role in hair greying...

The new method for measuring small changes in hair coloring opens up the possibility of using hair pigmentation patterns like tree rings. This could track the influence of past life events on human biology. In the future, monitoring hair pigmentation patterns could provide a way to trace the effectiveness of treatments aimed at reducing stress or slowing the aging process.”

Thyroid hormone deficiency slows metabolism, prompting the body to compensate by activating the sympathetic nervous system, which releases more norepinephrine to stimulate energy production and maintain homeostasis.

Ref: Quantitative mapping of human hair greying and reversal in relation to life stress

[bt @bt57414527]

@craigarious @MartinShkreli Mikhail was a brilliant man, but he did die in his early 60s; further, his acolyte, Dr. Alan Green, had died just a couple of weeks prior. Unsurprisingly, Bryan ceased his rapamycin within the same month.

[♰ 𝙽𝚊𝚎𝚝𝚘 @fw_naetoblaq]

“I asked ChatGPT” yeah well I asked my autistic friend whose pattern recognition gives her borderline prophetic accuracy even though no one ever listens to her because she’s awkward and has bad timing and says the wrong thing and has no control over her body or volume or brain or

[bt @bt57414527]

@DailyRedMeds @DrCamRx Bryan posted all of this stuff himself. “I Tried To Make My Face [Appear Artificially] Younger [By Injecting Someone’s Else’s Fat Into It]” https://t.co/wod3i84QN0

[Josie Zayner @josiezayner]

I hope your cognitive security is good because even the smartest people I know got some form of psychosis

[zeta @zeta_globin]

I'll probably get blocked (no offense bryan) but breast cancer overdiagnosis is in the low teens and overmonitoring is your primary risk factor for falling into that population

poll below: kate gets an early stage breast cancer dx from all the monitoring- do you think bryan will

A) launch an elaborate well thought out "what is cancer" arc
B) just switch females again

[tim @FlamingButtWind]

i'm not mansplaining i'm info-dumping they're not the same thing

[Jack @tracewoodgrains]

what a fun story

[Camus @newstart_2024]

Dr. Robert Lustig dropped a brutal truth on Steven Bartlett:

“You can’t love if your brain is inflamed.”

He explained that ultra-processed food, chronic stress, and reactive oxygen species inflame the brain, which wrecks two critical neurotransmitters:

- Serotonin — needed for contentment and emotional balance

- Oxytocin — the “love and safety” chemical

High cortisol literally blocks oxytocin from working, so people feel unsafe and disconnected. The result? They struggle to love themselves or anyone else.

Metabolic health isn’t just about your body. It directly affects your capacity for real human connection.

This one hit hard.

Do you think poor metabolic health and brain inflammation could actually be reducing people’s ability to love and connect — or is that going too far?

[The Forest of Symbols Podcast @AldousAsterion]

Tim Heidecker takes on the Alex Jones role as parody, only to uncover a real conspiracy. He slowly loses his mind as his audience finds him funnier and funnier the more genuinely he becomes a conspiracy theorist.

[alex harper ༻༺ @balefulrays]

That’s amateur hour; the true adepts are addicted to addiction and transmute it into obsessive work that breaks new ground

[bt @bt57414527]

@keysmashbandit Last year, ChatGPT similarly decided I needed to be in post-AGI Governance, and also refused to relent.

[bt @bt57414527]

@MetabolismPrism @NoahRyanCo He was already taking an aromatase inhibitor, so if anything, estrogen was too low and it led to joint pain later. I thought then (and now) that it was largely finasteride-mediated blunted neurosteroid production. Too great and too little can both be bad, in different ways.

[bt @bt57414527]

@punishedfounder Martin is legitimately very smart, likely north of 145. We have a mutual friend. He’s also willing to engage in deception (even self-deception) in the name of personal gain, is a reactionary uberskeptic, lost the plot in prison, and now is an out of touch, middle-aged dad.