Christian Gill

Infectious Diseases Pharmacist-Researcher, Soccer fan

[Christian Gill @c_gill11]

@DrToddLee @ABsteward @BradSpellberg I agree, I think the lack of meropenem activity against enterococcus is a myth. MICs are higher but I think we give enough meropenem for activity. I want to evaluate it in our mouse model with humanized meropenem exposures.

[Andrew Fratoni @AFratty]

CAIRD at Hartford Hospital (Hartford,CT) is actively recruiting for post-docs (PhD or PharmD) to join our lab! We've been training fellows in ID PK/PD for over 30 years.

Going to ASHP Midyear? Reach out to set up a timeslot in our PPS booth!

Reposts much appreciated! #IDtwitter

[Tomefa Asempa @PK_asempa_PD]

https://t.co/n6pHBL1K1K

New pub alert from the lab @hartfordhosp. 🚨💉Relevant study giving SUL-DUR's need to be given in combination for empiric coverage!!💉Take away: Synergy and no antagonism observed

[Christian Gill @c_gill11]

@merwimmer I would reach out to the manufacturer Cipla they should have some options. There was a commercially available assay in development but I think when Achaogen had closed shop it was lost in the shuffle

[Christian Gill @c_gill11]

@Ahsan70000122 @RachelCCpharmD There is a multistate outbreak of VIM and GES harboring PSA, if lab can test on carbaR it can pick up the VIM. I would check cefiderocol MIC. Ceftaz/avi+aztreonam is different in PSA vs enterobacterales. The aztreonam-avi MICs are much higher in PSA due to the other mechanisms.

[Christian Gill @c_gill11]

Recall due to VIM-GES-harboring P. aeruginosa contamination which has resulted in infections. Highlights need for carbapenemase-screening strategy in the US for carbapenem-resistant P. aeruginosa.

[U.S. FDA Recalls and Alerts @FDArecalls]

Global Pharma Healthcare Issues Voluntary Nationwide Recall of Artificial Tears Lubricant Eye Drops Due to Possible Contamination https://t.co/e5xmXv4DP8

[Christian Gill @c_gill11]

@IDPharmacometrx I noticed the same! Also thankful to the ASM programs committee to allow remote presentations

[Bug Pharmacist 💊🧫 Tim Gauthier @IDstewardship]

Porin channels
Enzymes
Change in the binding site
…and…

[RI Pharmacists @RIpharmacists]

The Rhode Island Pharmacy community lost a dear friend, pharmacist, entrepreneur, public service leader and beloved family member earlier this week, Anthony J. Solomon.

🔗Full post: https://t.co/fqYDu79l9Z

🔗Lifetime Achievement Award:
https://t.co/6YtT7wLBBd

1/n

[No Laying Up @NoLayingUp]

Spieth SZN

[Christian Gill @c_gill11]

@BWDionne @ErinMcCreary @OncIDPharmd @ryankshields @jpogue1 We’ve seen some unexpectedly low MICs to PipTazo specifically for VIM positive PSA. Like Sam said probably a shortcoming of PipTazo AST rather than true activity but would be interesting to evaluate.

https://t.co/EWVzO4PxzA

[Christian Gill @c_gill11]

@DanyaRoshdy @ryankshields @OncIDPharmd @davidvanduin Some IMPs as well as a number of other MBLs are outside the targets of the CarbaR. A phenotypic carbapenemase test (like the mCIM/eCIM) can detect other non targeted carbapenemases.

[Christian Gill @c_gill11]

@HFHPharmRes Looking forward to seeing what you find!

[Christian Gill @c_gill11]

@OncIDPharmd @ABsteward @MicrobLog_me_uk @IdVilchez @wfwrighID @a_hamprecht @DrToddLee @Boghuma @transplantID @AntibioticDoc @JGPharmD Have to be aware of the breakpoint differences with meropenem/vaborbactam having higher breakpoints than meropenem alone in context of OXA-48. vaborbactam offering no protection against OXA-48, but more OXA-48 will test S to MVB just due to higher breakpoint

[Christian Gill @c_gill11]

@OncIDPharmd @theIDPharmD Yikes too close to home! Interested how the phenotypes shake out

[Christian Gill @c_gill11]

@OncIDPharmd @theIDPharmD I believe oxa-48 as well https://t.co/3m3hQuWrp7

[Christian Gill @c_gill11]

@SC_Pharmacist Current ID PKPD fellow always happy to share.

[Christian Gill @c_gill11]

@toni_pharmd Not uncommon ha sorry phone typo

[Christian Gill @c_gill11]

@toni_pharmd Would caution daptomycin alone- resistance or uncommon and can develop after exposure https://t.co/6kEpxUwIQc

[Christian Gill @c_gill11]

@OncIDPharmd @DrToddLee @sebpoule Would also consider GES-beta-lactamases. have been reported in Canada and I would bet crossing over into US but none of the commercially available platforms can detect https://t.co/my0SrFBSwo