Cosy Go

#LongCovid Oct 2020

[Cosy Go @c_ixulescu]

My "switcher was a bad one with a f…... timer."
Two complete spontaneous remissions for just 12 and 20 Hours and then the hell again. @chydorina good luck!

[🕸️Dr.T, PhD @chydorina]

Microgliosis (reactive change in microglia) is a common feature of post-viral illness including #MECFS, #SARSCoV2, #HPV.

Its one mechanism that might "flip the switch" during a @remissionbiome event.

We are getting at the brain through the gut.

[Christoph Bammer @CBammerMD]

Es ist ziemlich spannend, was sich lt. Dossier Newsletter diese Woche im Verwaltungsgericht Wien zugetragen habe.

Ein Rechercheteam um Dossier, APA und ORF hat 01/2026 eine Anfrage nach dem Informationsfreiheitsgesetz gestellt mit der Frage: Was vermittelt die PVA ihren

[Vipin M. Vashishtha @vipintukur]

A saliva test plus a blood marker may help identify #LongCOVID.

➡️ Patients showed higher salivary anti-nucleocapsid IgA and lower C3 complement levels, pointing to persistent immune activation and complement dysregulation.

➡️ These findings bring us one step closer to an objective biomarker—and perhaps new complement-targeted treatments—for LongCOVID.

H/T: @CatchTheBaby

https://t.co/G7kJUcVGih

[Luis @lulopson]

@stkirsch Persustent infections are cause n 1 of autoinmune conditions. Sars-cov-2 is particularly good at increasing autoimmunity odds.

[Harry Spoelstra @HarrySpoelstra]

Folic Acid and Endothelial Dysfunction in COVID-19

🚨LongC0VID still has zero proven treatments. 🧵

➡️A new Argentinian review shows folic acid could protect blood vessels from the endothelial damage driving both severe cases and persistent symptoms, by lowering homocysteine, boosting nitric oxide, and countering the gut disruption COVID causes,

Sceptical? Same here!

➡️But when we literally have nothing else that works, dismissing a cheap, safe vitamin without proper trials is no longer cautious, it may even be negligent,

And, if there’s no added value, it certainly won’t harm you to try!

➡️Some interesting points from this review:
1. Endothelial dysfunction drives severe acute COVID-19 (inflammation, thrombosis, organ damage, ICU needs) and longC0VID/PASC symptoms,

2. Homocysteine metabolism is frequently dysregulated in COVID-19 inflammation. Elevated levels correlate with higher clotting risk, severe pneumonia, ICU admission, and mortality. Severe patients often show low folate and high homocysteine,

3. Folic acid (vitamin B9) lowers homocysteine, reduces oxidative stress, supports nitric oxide production (improving vasodilation and reducing inflammation/clotting), and may exert direct antiviral effects by interfering with SARSCoV2 entry/replication proteins,

4. SARSCoV2 disrupts the gut microbiome, reducing natural folate production by beneficial bacteria and worsening deficiencies/inflammation,

5. Evidence cited includes biomarker studies, computational/lab data on mechanisms, genetic susceptibility links, and some clinical observations where nutritional support including folic acid was associated with reduced mortality and mechanical ventilation needs,

6. Supplementation is discussed as a low-cost complementary strategy for acute phase and longC0VID (with vitamin B12 also noted for LC/PASC👇),

7. It is not presented as a cure or standalone treatment,

8. The review does call for larger, well-designed clinical trials to confirm indication, optimal dosing, efficacy, and patient subgroups.

‼️So, Folic acid shows credible mechanistic promise as an affordable vascular shield against COVID-19’s endothelial assault, yet we still have zero proven treatments for LongC0VID. Without urgent, large-scale trials, millions will keep suffering preventable clotting, organ damage, and chronic symptoms while a simple, cheap B-vitamin may sit underutilized. The paper’s evidence is suggestive and certainly not definitive. Treating this as “just another supplement” or dismissing it outright risks turning a potential low-cost adjunct into yet another missed opportunity in a disease that continues attacking blood vessels long after the virus is gone.
The evidence is preliminary. The need to test it seriously is not, anything that may help needs our attention! Meanwhile:
#AvoidSars2 #AvoidReinfections 1/2
https://t.co/NOTdKDM743

[Christian Haberhauer @c_haberhauer]

ME/CFS: Internationales EU-Forschungsprojekt "DISCOVER-ME" gestartet

Unter Leitung von Eva Untersmayr-Elsenhuber @MedUni_Wien, auch Co-Leiterin des PAIS-Referenzzentrums.

Mehr als 7,5 Mio. Euro Förderung für 4 Jahre

siehe:
https://t.co/ANbJKvvQCo

[Michael Stingl @neurostingl]

Super Nachrichten!

Wichtig, dass diese Forschung auch in Österreich stattfindet.

[Michael Stingl @neurostingl]

Mich magerlt das Framing wirklich.

Zwei-Klassen-Medizin ist, wenn man mit Zusatzversicherung schneller zur Hüftprothese kommt.

Wenn Menschen mit ME/CFS überhaupt keinen funktionierenden Zugang zu Diagnostik, Therapie, Absicherung haben, ist das Systemversagen.

1/5

[🕸️Dr.T, PhD @chydorina]

This is what happens when bacterial LPS - lipopolysaccharides (toxins) are injected into healthy people.

They feel shitty (i.e. this is called 'sickness behaviour' and is a medical term for specific cytokine mediated behaviors that accompany immune responses).

Now, imagine that you have bacterial pathogens and commensals spewing out LPS on an ongoing basis (this is part of what high whole body pathogen load leads too).

You will feel really shitty.

This is why managing whole body pathogen load is so important. Removing pathogenic bacteria (using bacteriophage therapy) and replacing with good probiotic bacteria - so that the baddies cannot bloom and outcompete the 'goodies'.

Choose a system to start with - your oral cavity, your nasal cavity, your ears, your skin, your colon (i.e. colonics/enemas), your gut, or your privates. Just start lowering whole body pathogen load.

bacteriophage therapy: https://t.co/W1GnZN8U1v

In less than a week - an oral bacteriophage spray cleared up the horrible oral pathogen situation I had going on. My tongue looks normal now for the first time in a decade. Its quite shocking actually how fast the changes are occurring.

Lipopolysaccharide-induced changes in the kynurenine pathway and symptoms of sickness behavior in humans
https://t.co/n75AiUsM42

[ApocaLiz @Lizzardo77]

@brokenbarpublic Oh but there is! CBT, breathwork, parasympathetic activation, nidra yoga, smart watches, red light therapy, 17 million supplements to guinea pig, brain retraining, SSRIs, and LDN! I'm sure I'm missing some! We're swimming in treatments! 🙃

[Michael Stingl @neurostingl]

Die Stellungnahme der DGNB ist nun auch im Nervenarzt erschienen.

Ähnliche Stellungnahmen haben in der Vergangenheit leider dazu geführt, dass gutachterlich ME/CFS und Long Covid an sich delegitimiert werden.

1/n https://t.co/n1Vy37c32u

[Putrino Lab @PutrinoLab]

Concerning story about #COVID, #LongCOVID and cancer risk. Dovetails with the work we have been been doing with @drmfreire's team showing that persistent SARS-CoV-2 antigen found in the GI tract of pwLC is pro-inflammatory and oncogenic:
https://t.co/0jCfaCXQj0

Stay safe 🙏

[Putrino Lab @PutrinoLab]

A thread today about Immunoglobulin G (IgG) antibodies to various pathogens and why they seem to be elevated a lot in people with #LongCOVID, #MECFS, chronic #lyme/tick- and vector-borne illnesses and other complex chronic illnesses. First, let's start basic: what is IgG?
1/

[Brian Fog @useless_priest]

83% of POTS patients in this group* were found to have pelvic venous compression or pelvic venous congestion.

Stenting led to a significant improvement in orthostatic intolerance symptoms.

* patients already had symptoms pointing towards pelvic venous issues

[Zdenek Vrozina @ZdenekVrozina]

Tasoula at al., Multi-omics analysis of long COVID (post-COVID-19 condition) reveals persistent mitochondrial dysfunction, suppressed oxidative phosphorylation, and immune dysregulation. https://t.co/XQfsxRxilO

[DMZ - News 🦉🗞️ @NewsDMZ]

Hinweise auf autoimmune Untergruppe bei Long Covid – neue Studie differenziert das Bild der Erkrankung https://t.co/61SKBS2G6X

[Constanze Ertl @ErtlConstanze]

Im Mai 2025 haben @eja_kapeller @c_haberhauer und ich gravierende Missstände bei den Begutachtungen bei #MECFS und #PostCovid aufgedeckt. Seither ist die PVA wenig auskunftsfreudig, auch auf Anfrage nach dem Informationsfreiheitsgesetz, deshalb gehts jetzt vor Gericht 1/4

[Michael Stingl @neurostingl]

Es ist ein spannendes Bild, das da entsteht.

[Brian Fog @useless_priest]

Link: https://t.co/fRpNcAVXUF

[Brian Fog @useless_priest]

"POTS can be a legitimate Long COVID finding if objectively diagnosed.

Reduced HRV is not diagnostic.

"Leaky gut" is not accepted as a valid diagnosis or proof of PCS.

No current blood test or biomarker can definitively diagnose PCS or prove COVID causation."

[Jon Douglas @atranscendedman]

UIC, 30 participants. Long COVID with periodontitis showed broad loss of salivary microRNAs that normally dampen NFκB inflammation and can bind SARS-CoV-2 RNA.

Restoring them reduced inflammatory signals and viral genes in cells.

https://t.co/TtZqoSJ078