Cadwell Lab

We investigate the interface between the immune system and diverse infectious agents ranging from friendly gut microbes and viruses to disease-causing parasites

[Cadwell Lab @CadwellLab]

Overall, we discovered that an intervention as simple as changing cages can control duration of viral infection in mice. Huge shoutout 🙏 to Christin and coauthors, the Gnotobiotics core at both Penn and NYU, and PennCHOP microbiome program for making this study possible 5/5

[Cadwell Lab @CadwellLab]

Congratulations Christin Herrmann and team for publishing this super cool discovery 😎 https://t.co/FbXtzG2t4n Here’s a quick summary of our cool findings about how stress due to simple mouse husbandry drives clearance of persistent enteric viral infection 🦠🐭 1/5

[Cadwell Lab @CadwellLab]

Cage change is a stress-inducing event for 🐭! We found that the fluctuation of glucocorticoids (hormones released under stress) contributes to viral clearance, and interference with this hormonal stress response actually inhibits MuAstV clearance after cage change! 4/5

[Cadwell Lab @CadwellLab]

Once again, 🙏NIH for making this possible and our amazing coauthors. Special shoutout to coauthors Patty Martin and @TorresVJ_Lab for launching this project. Read paper for details and credit to literature for background 5/n

[Cadwell Lab @CadwellLab]

Congratulations @Ipiricyao and Eugene Rudensky for publishing this story! Big 🙏to NIH for making this work possible. Here’s a brief summary of this fascinating finding about a gene variant that YOU🫵most likely have 1/n
https://t.co/objLYQzJyZ

[Cadwell Lab @CadwellLab]

Maybe ATG16L1 T300A is under balancing selection, like hemoglobin and APOL1 variants that are protective if you have 1 copy but 2 copies are bad (sickle cell/kidney disease)🤷‍♀️? Lots of❓ surrounding mechanism that we’re continuing to work on 4/n

[Cadwell Lab @CadwellLab]

Congratulations @YingHanChen7121 and Kim Zaldana for showing how B cells are altered when lab mice are released outdoors!
https://t.co/yrts4bOXlm
1/n

[Cadwell Lab @CadwellLab]

We are eternally grateful that the NIH officers and reviewers have expressed enthusiasm for these types of studies. Return in investment for the growing dirty 🐁field is huge 🤯and will help industry, and gov’t funding is essential to support the next phase! 9/n

[Cadwell Lab @CadwellLab]

Congratulations @YingHanChen7121 and Kim Zaldana for showing how B cells are altered when lab mice are released outdoors!
https://t.co/yrts4bOXlm
1/n

[Cadwell Lab @CadwellLab]

Recently, we received a great score 👍on a previous NIH grant and hope we can get it funded after incorporating helpful suggestions from reviewers 8/n