Miriam Merad, MD, PhD

Director, Immunology Institute @SinaiImmunol @IcahnMountSinai | Harnessing the innate immune system for novel therapies against cancer & inflammatory diseases.

[Eric J. Nestler, MD, PhD @EricJNestler]

I am incredibly proud of @IcahnMountSinai's faculty and trainees whose cutting-edge, impactful research brought Mount Sinai into the top 10 of NIH-funded institutions for the first time in FY26.

[Matthew D. Park, PhD @MatthewD_Park]

Recently presented work @sitcancer from @MiriamMerad lab @IcahnMountSinai @TischCancer x Jianjun Jay Zhang et al at MD Anderson on targeting IL-1 to intercept lung precancers. Scope of IO is expanding + chronic inflammation has to be at the center of cancer care moving forward!

[OCCAM Immune @Occamimmune]

Our CMO Dr. Thomas Marron (@DrTomMarron) has been a force for OCCAM Immune at #SITC26! Here he is at Booth #1031 with our CEO Erik Wambre (@WambreErik) and CSO Seunghee Kim-Schulze, talking spatial profiling of the tumor microenvironment. #ImmunoOncology

[Miriam Merad, MD, PhD @MiriamMerad]

Great example of how scientists approach a problem! Thanks to @zmallat for sharing data showing that the number of Nobel laureates correlates with investment in R&D. The question now is what will happen to the number of US Nobel laureates if we continue to cut research funding?

[Ziad Mallat @ZMallat]

@MiriamMerad Cadeau d’un ami 😜

[Miriam Merad, MD, PhD @MiriamMerad]

Arabs contributed immensely to knowledge from the 9- 14th centuries, not because they were smarter but because research was valued and funded. If the US continues to defund research, Americans will also stop winning Prizes. History is our best guide,if we interpret it correctly.

[Bulwark Clips @BulwarkClips]

RFK: "There's five hundred million Arabs in the world. And yet they don't produce science. They don't win the Novel Prize. They don't win the Fields Prize. They don't win the Wolf Prize. They don't produce literature."

[Miriam Merad, MD, PhD @MiriamMerad]

2nd message: Vaccines led to 40% of the global decline in infant mortality attributable to vaccination. Now we are learning they may also protect against dementia. More reason to deepen our understanding of vaccine biology!

[Miriam Merad, MD, PhD @MiriamMerad]

Great summary of studies linking vaccination to reduced dementia risk with 2 messages: 1/Peripheral inflammation contribute to neuroinflammation, cognitive decline & dementia. Controlling systemic inflammation may be key to healthy brain aging (1/2) https://t.co/bbUW7ZxGPl

[Miriam Merad, MD, PhD @MiriamMerad]

Congratulations @ScottRussoPhD ! you are going to be a fantastic chair ! and I look forward to bringing neuroscience and Immunology even closer together

[Eric J. Nestler, MD, PhD @EricJNestler]

This appointment is especially meaningful to me since @ScottRussoPhD first joined my lab then at UT Southwestern at Dallas as a postdoc in 2003 and was my first faculty hire when I moved to @IcahnMountSinai in 2008.

[Miriam Merad, MD, PhD @MiriamMerad]

@EricJNestler @IcahnMountSinai Wow - that’s super cool !

[Joshua Brody, MD @JoshuaBrodyMD]

The dark and scary tunnel of possible side effects from #CART therapy just got a bit brighter and clearer as a brilliant team led by Drs. Kethidi, Parekh and Mehandru @MountSinaiNYC discover cause and potential treatments for CART-induced #enterocolitis
https://t.co/BoDKTNaZkN

[Miriam Merad, MD, PhD @MiriamMerad]

In this article, I argue that pandemics, antimicrobial resistance, cancer, inflammatory diseases & aging are among the greatest threats to our societies. Yet biomedical research receives a fraction of military spending, when in fact the #NIH is also a “Department of Defense”.

[Nature Rev Immunol @NatRevImmunol]

Academic biomedical research is national defence https://t.co/Hbi3PjGNFy

[Miriam Merad, MD, PhD @MiriamMerad]

I enjoyed contributing to this @nytimes piece on the role of macrophages in driving inflammation, how chronic inflammation contributes to many major human diseases, and the growing potential of targeting inflammation to prevent and treat disease. @SinaiImmunol #Inflammation

[The Mark Foundation for Cancer Research @TheMarkFdn]

How does chronic inflammation shape our risk for cancer & other diseases as we age? 🔬

Great piece in the @nytimes exploring the latest science, including insights from @MiriamMerad, who was recently awarded funding by @TheMarkFdn, @WaxmanCancer, & @AmericanCancer to study inflammation & aging. https://t.co/mAg0T46JdK

[Miriam Merad, MD, PhD @MiriamMerad]

@NCIDirector @theNCI Many of us are working full force on these questions. But funding cuts, delays and uncertainty are limiting our ability to pursue ambitious science and recruit the brightest minds. We need the sustained funding and ambition this moment demands !

[Miriam Merad, MD, PhD @MiriamMerad]

@EricJNestler @SinaiBrain @IcahnMountSinai I very much enjoyed this forward-looking commentary. I share the excitement about the extraordinary possibilities ahead. We are proud to have you lead Sinai with such clarity and focus on molecular science as a transformative force for medicine @IcahnMountSinai

[Miriam Merad, MD, PhD @MiriamMerad]

Very grateful to @FGinhoux, @MartinGuilliams, @MatthewD_Park, @samhegde2006, and @naderyatim for the insightful discussions and input that helped shape this commentary. (4/4)

[Miriam Merad, MD, PhD @MiriamMerad]

Very pleased to share this new commentary on the extraordinary biology of resident tissue macrophages (RTMs). RTMs are the most evolutionarily conserved immune cells. They emerged before adaptive immunity and blood circualtion (1/4) https://t.co/9t0FmXz3jt

[Nature Rev Immunol @NatRevImmunol]

Macrophages are constitutive architects of tissue integrity https://t.co/QG4QCjUJV6

[Miriam Merad, MD, PhD @MiriamMerad]

I also discuss how RTMs decline with age increases susceptibility to severe infections, and organ dysfunction with age & argue that RTMs are untapped therapeutic targets and that harnessing TM could transform disease prevention, tissue regeneration, and healthy aging. (3/4)

[Miriam Merad, MD, PhD @MiriamMerad]

@IdoAmitLab @ScienceMagazine @jboumelha @SinaiImmunol Thank you 🙏

[Miriam Merad, MD, PhD @MiriamMerad]

Excited to share our new study @ScienceMagazine by the fantastic Raphael Mattiuz and @jboumelha @SinaiImmunol showing how DC build and sustain tertiary lymphoid structures in cancer. A major step toward enhancing anti-tumor immunity (1/2) https://t.co/H8awCDz0HM

[Miriam Merad, MD, PhD @MiriamMerad]

@MartinGuilliams @jonykipnis @ScienceMagazine @jboumelha @SinaiImmunol thank you Martin