Does scale limit what we can discover?
In our new @NatureGenet study, led by @MorZada3 & @Anna_Kurilovich, we built a 427-sample single-cell atlas of multiple myeloma across 341 individuals, linked to genetics and detailed clinical data 🧵 (1/15)
🔗 https://t.co/6XusMDMDN8
Wrapping up an unbelievable year of growth, discovery, and achievement at Amit Lab with our annual lab retreat!
Proud of this incredible team and more confident than ever about the future of immunology and immunology-based therapies! 🚀
Macrophages wear many hats: from guardians of tissue health to architects of tumor niches and targets for therapy. Explore their remarkable plasticity, from homeostasis to disease and back, in the new @TrendsImmuno special issue.
https://t.co/9sMRxF6Auh
What comes after M1/M2? In our Perspective with @FGinhoux in @ImmunityCP we explore how single-cell technologies and AI can decode the gene programs macrophages use across tissues & microenvironments, and how this modular view could transform immunotherapy
https://t.co/o3CgVmKWBZ
@logicwolf133544@FGinhoux@ImmunityCP Good point! Macrophage states are shaped by additional layers of regulation, including upstream signals. Our goal was to move beyond M1/M2 toward a more precise framework that explains the data, underlying mechanisms, and therapeutic implications. More in future Perspectives!