Immunity

Cutting-edge research in immunology from around the world. This account is no longer monitored, and content is automated. Join us on LinkedIn!

[Immunity @ImmunityCP]

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[Immunity @ImmunityCP]

@NVanRenne @IdoAmitLab @MartinGuilliams @FGinhoux Free access until 12/5/26

https://t.co/OwPT9ayp4u

[John Lukens @LukensJohnR]

Embracing macrophage complexity for research and translation. https://t.co/BXlbfejcF4 @ImmunityCP

[Eric Topol @EricTopol]

Spotlighting the macrophage cells in our blood and tissue, their role in diseases, and targeted interventions
https://t.co/dmcdQJCrnj @ImmunityCP

[IdoAmitLab @IdoAmitLab]

What comes after M1/M2? In our Perspective with @FGinhoux in @ImmunityCP we explore how single-cell technologies and AI can decode the gene programs macrophages use across tissues & microenvironments, and how this modular view could transform immunotherapy
https://t.co/o3CgVmKWBZ

[Extracellular Matrix News @ExtracellMatrix]

This @ImmunityCP study found that #microglia exhibited acute and progressive morphological responses that preceded but paralleled ethanol-induced sedation.

📖 https://t.co/U9vzT5FbvJ

First authors Evi Paouri and Sarah Stanko show that genetic deletion of microglial Myd88 protect against ethanol-induced microglial reactivity, neuronal damage and dysfunction, intoxication, and motor impairments by preventing #ECM disruption.

[Immunity @ImmunityCP]

Online now: Embracing macrophage complexity for research and translation dlvr.​it/TVxZsp

[Immunity @ImmunityCP]

Online now: Lactate dehydrogenase A-dependent redox control of selective mRNA translation directs monocyte fate commitment dlvr.​it/TVwwlg

[Immunity @ImmunityCP]

Online now: Dan Kastner (1951–2026) dlvr.​it/TVwpWt

[Extracellular Matrix News @ExtracellMatrix]

Using temporal multi-omics, biomechanical profiling, and spatial fate mapping in #colitis models, @WeizmannScience researchers showed that colonic #ECM underwent lasting pathological reprogramming following inflammation.

🔎 https://t.co/BBE4v91pkd

Their findings, published in @ImmunityCP, redefine the ECM as a long-lived instructive compartment that encodes injury memory and promotes maladaptive regeneration.

[Tsinghua University @Tsinghua_Uni]

Can our immune system remember a virus for 20 years? Prof. Zhang Linqi’s Innovative Tsinghua team @MedTsinghua found that SARS-CoV-1 immune memory can endure for two decades in @ImmunityCP, providing new insights for broader vaccines with @HKUniversity and other collaborators.

[Eric Topol @EricTopol]

Unraveling the immune system's role in our healthspan
Breaking down a seminal study just published @ImmunityCP
https://t.co/f4A7LaN4Wf

[Immunity @ImmunityCP]

Online now: Skin-resident CXCR6+ memory CD4+ T cells and dendritic cells form dermal perivascular hubs that drive relapse in allergic dermatitis dlvr.​it/TVtT2v

[John Lukens @LukensJohnR]

Induced regulatory B cells stably expressing interleukin-10 reverse central nervous system autoimmunity by targeting myeloid cells. @ImmunityCP https://t.co/LGI8RHsOmv

[MariusMessemaker @MariusMessemak1]

Out in @ImmunityCP : We expanded to >2,500 TCRs and 8 epitopes and find that ~half of TCR-pMHC pairs do not validate. On clean data, we show that modeling reactivity with AF3 & tcrdist3 is more feasible than assumed. Is your model better? Join IMMREP26! 🧵
https://t.co/ulZVC9d2MF

[Eric Topol @EricTopol]

A seminal paper on aging of our immune system was just published. From study of over 12 million single-cells in 8 cohorts, >2,600 individuals, ranging in age from 18 to 98. Yielding a practical blood test. And much more.
A Tale of Two T cells
In the new Ground Truths

[Waggoner Lab @LabWaggoner]

CD8+ Tem GZMK+ to GZMB+ ratio distinguishes healthy from disease-associated trajectories and predicts mortality risk @ImmunityCP
https://t.co/CVeqG0UynF @maxim_artyomov @WashU @nikart89 @NationwideKids @KingsCollegeLon

[Waggoner Lab @LabWaggoner]

Lymph node lymphangiogenesis encapsulates activating germinal centers to constrain their size, which enhances clonal selection and protective antibody responses @ImmunityCP
https://t.co/atX7MBQaMe @nyugrossman @theLundLab

[John Lukens @LukensJohnR]

Microglia-mediated extracellular matrix disruption drives neuronal dysfunction, motor impairments, and sedation following alcohol abuse. @ImmunityCP https://t.co/8GZ0kMZz0j

[Eric Topol @EricTopol]

A remarkable study of 12 million single-cells (RNAseq) from 8 cohorts plus proteomics to determine the immune cells linked to healthy aging. Major findings included:
—thymic involution is central (decline in naive T cells and thymic emigrants)
—elevated immune system activation, inflammaging
—CD8+ memory cells (GZMB+) high frequency
—CMV seropositivity and chronic disease
@ImmunityCP by @maxim_artyomov and colleagues
https://t.co/aQNQiapfPV

[Amanda Lund Lab @theLundLab]

💡 What sets the size of a germinal center? — why lymphatics of course 😉

Our new study with Carla Nowosad reveals how lymphatic remodeling constrains germinal center growth and shapes the quality of the antibody response. @ImmunityCP @nyugrossman

https://t.co/g1RXqZ1tc7