CDD press

SCIENTIFIC JOURNAL group by @SpringerNature Cell Death & Differentiation, Death & Disease, Cell Death Discovery

[CDD press @cddpress]

“Targeting the circ_0042819-PLA2G6 axis sensitizes multiple myeloma to proteasome inhibitors through ferroptosis induction”

A novel oncogenic #circRNA and potential non-invasive #Biomarker for the diagnosis and prognosis of #MultipleMyeloma ⤵️
https://t.co/DbLawqoknF

[CDD press @cddpress]

“Transcriptional alterations in SKAP1-associated inside-out signaling in CNS-infiltrated pediatric T-cell acute lymphoblastic leukemia”

Novel mechanistic insight into cancer progression and potential therapeutic vulnerabilities in #PediatricLeukemia ⤵️
https://t.co/SvQT5026Yi

[CDD press @cddpress]

“Physiological APP processing is required for synaptic plasticity and cognition”

Whether endogenous, physiological APP processing plays an essential role in normal brain function has long remained an open question ⤵️
https://t.co/6bbn2ndikz

[CDD press @cddpress]

“ENPP1 inhibits the cGAS–STING pathway to mediate immune evasion in EGFR-TKI–resistant non–small cell lung cancer”

These data support ENPP1 as a promising therapeutic target to enhance #Immunotherapy efficacy in EGFR-TKI–resistant #NSCLC ⤵️
https://t.co/HFwQ2hqpdz

[CDD press @cddpress]

“JNK signalling balances apoptosis and cell survival during tissue stress”

A good and a bad cop wrapped in one: sequential control of #Apoptosis and cell survival by JNK signalling during epithelial tissue repair ⤵️
https://t.co/vFMMER97as

[CDD press @cddpress]

ADA2 safeguards mitochondrial health in #Macrophages. Its loss disrupts #Autophagy, triggers mitochondrial DNA leakage and fuels cGAS–STING–IFN-I signalling—linking mitochondrial stress to inflammation in #DADA2 ⤵️
https://t.co/qzSthTeoo2
@MortellaroLab

[CDD press @cddpress]

“XIAP induces inflammation and promotes colorectal cancer progression”

An additional, mechanistically distinct function of XIAP in regulating the #TME and promoting #CRC progression ⤵️
https://t.co/I9u1kYreMT

[CDD press @cddpress]

“A 5′ tRNA-derived fragment tDR-Glu-TTC exacerbates intestinal ischemia/reperfusion injury via ADAR1/autophagy/ROS/necroptosis signaling axis”

tDR-Glu-TTC regulates #Necroptosis via epitranscriptomic editing in intestinal I/R injury ⤵️
https://t.co/Uake1RSXJS

[CDD press @cddpress]

November is Lung Cancer Awareness Month 🎗️

Explore our collections featuring the latest research published in:
🔬 Cell Death and Disease: https://t.co/FaouOdZKQ4
🔬 Cell Death Discovery: https://t.co/KsT8uBLiGx

#LungCancerAwarenessMonth #LungCancer #CancerResearch

[gerry melino @melino_G]

Accademia Lincei hosting a Cancer Meeting with Tak Mak, Arnie Levine, Raul Rabadan, Jemie Blundell…..excellent!?!!

[gerry melino @melino_G]

Tak MAK opening the Cancer Meeting at the Lincei Academy

[CDD press @cddpress]

“Non-canonical caspase-8 activation by cathepsin B drives anti-inflammatory human macrophage polarization”

This work positions the CTSB–non-canonical caspase-8 axis as a mechanistic checkpoint of human #Macrophage plasticity ⤵️
https://t.co/Cvc0GpOOh1

[CDD press @cddpress]

“SMARCA5 facilitates cohesin localization at R-loops to prevent transcription-replication collisions”

This work reveals a novel mechanism linking transcription-associated #DNARepair to replication stress responses and cancer cell survival ⤵️
https://t.co/SSiI9t925x

[CDD press @cddpress]

“miR-195-5p controls apoptotic cascade by regulating the XIAP/BCL2/Survivin network in colorectal cancer”

A promising pleiotropic #TumorSuppressor capable of restoring apoptotic sensitivity in #CRC ⤵️
https://t.co/kAsh2mJgqB

[CDD press @cddpress]

“Apoptotic cell overload drives multinucleated giant cell formation after neoadjuvant chemotherapy in colorectal cancer: molecular mechanisms and tumor-suppressive effects”

A link between therapy-induced #CellDeath and anti-tumor myeloid remodeling ⤵️
https://t.co/ZvqyGqmvcD

[CDD press @cddpress]

“Fhl2 promotes chondrocyte ferroptosis in osteoarthritis by impairing mitophagic flux through microtubule disorganization”

Targeting these pathways may offer new strategies to limit #Ferroptosis-associated cartilage loss in #Osteoarthritis ⤵️
https://t.co/5BU6jDytvO

[CDD press @cddpress]

“Chidamide induces ROS-driven ZAKα-dependent ribotoxic stress in endometrial cancer and enhances radiosensitivity in vitro and in vivo”

This work supports further development of chidamide-based strategies for high-risk #EndometrialCancer ⤵️
https://t.co/J3rNYoIoST

[CDD press @cddpress]

“Glutamine synthesis pathway promotes the survival and recurrence of dormant tumor cells in prostate cancer”

This work suggests that the combination of #HormonalTherapy and GS inhibitors may overcome therapeutic #Resistance ⤵️
https://t.co/8y9BmIvPEj

[CDD press @cddpress]

“The NEK8/ALYREF axis promotes cisplatin resistance in bladder cancer by stabilizing CDK18 mRNA to facilitate DNA damage repair”

Targeting the NEK8/ALYREF/CDK18 axis may offer a potential strategy to overcome #Chemotherapy resistance in #BCa ⤵️
https://t.co/UdJaTwz4R6

[CDD press @cddpress]

“Targeting FEN1 disrupts EIF4A3-mediated MUC1-C autoregulation: a novel strategy to suppress lung adenocarcinoma progression”

These findings unravel the dual role of FEN1 in regulating #LUAD cell malignancy and tumor #Immunity ⤵️
https://t.co/XOZWynr1dA