Chas Boyden

[Mo @atmoio]

AI is making CEOs delusional

[Owen Gregorian @OwenGregorian]

Daily vitamin B3 dose cuts skin cancer risk by up to 54% | Bronwyn Thompson, New Atlas

A common, over-the-counter form of vitamin B3 has emerged as an inexpensive ally in protecting us from skin cancer, lowering the risk by an average of 14% and increasing to a massive 54% for anyone who has previously had a positive diagnosis. This latest study of more than 33,000 patients supports earlier evidence that emerged in a 2015 Australian trial.

Researchers from Vanderbilt University Medical Center conducted a large real-world analysis of US veterans, which looked at the health records of 33,822 individuals, comparing those prescribed niacinamide (typically 500 mg twice daily for more than 30 days) with matched patients who didn’t take it.

Overall, niacinamide – also known as nicotinamide, a vitamin B3 form found in food and supplements that supports cellular energy, DNA repair and healthy skin – was associated with a 14% lower risk of developing skin cancer. When people began nicotinamide after having earlier received a positive skin cancer diagnosis, the reduction in risk was 54%. What's more, the effect was seen in both basal cell carcinoma and cutaneous squamous cell carcinoma, with the largest drop in squamous cell cancers.

“There are no guidelines for when to start treatment with nicotinamide for skin cancer prevention in the general population," said corresponding author Lee Wheless, M.D., assistant professor of Dermatology and Medicine at Vanderbilt University Medical Center. "These results would really shift our practice from starting it once patients have developed numerous skin cancers to starting it earlier. We still need to do a better job of identifying who will actually benefit, as roughly only half of patients will develop multiple skin cancers."

While basal cell carcinoma, which generally affects areas of the skin that have endured longterm exposure to the Sun, develops slowly, they can be easily missed for some time and surgery can be significant. (In 2024, I had surgery to remove one measuring 0.4 cm in diameter, which required a deep and wide excision, and around 20 subcutaneous and surface stitches.) Cutaneous squamous cell carcinoma, meanwhile, are cancerous growths on a more surface layer of skin. These, along with melanoma, make up the three malignant skin cancers.

People tend to underestimate the impact and seriousness of non-melanoma cancers. The US spends more than US$8 billion each year in treating skin cancer – and a majority of that cost ($4.8 billion) is to address non-melanoma types.

In general, niacinamide has been shown to help skin cells repair UV-induced DNA damage, and it blunts some of the immunosuppressive effects of sunlight. While observational, so causation can't be proven, this study is by far the biggest dataset yet on niacinamide's everyday performance outside of controlled clinical trials. The veteran cohort also skews older and male (average age 77 and predominantly white men), and the researchers caution that studies on a more diverse demographic are needed to see if these results can be replicated more broadly.

However, it does echo the findings of the groundbreaking 2015 ONTRAC phase-3 trial in Australia, which demonstrated that 500 mg of niacinamide twice daily lowered the incidence of new non-melanoma skin cancers by about 23% over 12 months in 386 high-risk adults with prior skin cancers. And this protective factor diminished once the individuals discontinued the treatment.

While the researchers urge that this is no replacement for covering up and applying sunscreen to exposed skin, for people who’ve had a first basal or squamous cell carcinoma removed, a daily niacinamide regimen is emerging as a practical, inexpensive way to lower the odds of a recurrence. And this study gives clinicians and patients more real-world numbers to weigh when deciding whether these supplements could be of benefit.

"The results of this cohort study suggest that there is a decreased risk of skin cancer among patients treated with nicotinamide, with the greatest effect seen when initiated after the first skin cancer," noted the researchers.

"Nicotinamide, a simple vitamin B3 derivative, is showing real promise as a practical tool for skin cancer prevention," said Dr Yousuf Mohammed, a Senior Research Fellow at the University of Queensland. "These findings highlight that timing matters; starting earlier may be the key to stronger protection. For clinicians, the appeal of nicotinamide lies in its accessibility, safety, and tolerability. Unlike systemic retinoids or invasive field therapies, nicotinamide is inexpensive, over-the-counter, and free from significant side effects.

"Overall, these results reinforce what many dermatologists have long suspected, nicotinamide is an underutilized, low-risk intervention that can make a difference in reducing skin cancer burden, especially for patients with an early history of disease," he added.

Read more:

https://t.co/B1MACFG0Cn

[jay plemons @jayplemons]

The Basket Case Theory

@ScottAdamsSays “Everybody looks good until you get to know them.

Once you get to know a human being, they’re always basket cases.

Always.

Just different kinds of baskets.”

Full CWSA episode and Meaningwave music video below

[Alan Silvidi 🍀 @ASilvidi68]

Hey, @Fallout_Rocks plays @TheOutpostKent this upcoming Friday (March 24). Haven't been to one of our shows? This would be a fun one to come to! We go on at 8.

[Chas Boyden @ceboyden]

@Fallout_Rocks @VotemPete @ASilvidi68 Grog Shop - Get your tickets here! https://t.co/lalYHOAHZN

[Chas Boyden @ceboyden]

@Fallout_Rocks

[Fallout @Fallout_Rocks]

Fallout is @WaterStTavern 6-9 pm. Come on down for a happy hour party

[Alan Silvidi 🍀 @ASilvidi68]

As we head into the work week, just a reminder that this Friday, December 2, I'll be playing with Fallout @WaterStTavern in Kent from 6-9 PM. Hope you can make it!

[Chas Boyden @ceboyden]

@FTX_Official

[Chas Boyden @ceboyden]

@FTX_Official

[FTX @FTX_Official]

#bitcoin is time and time is #bitcoin

Or so the adage goes...

[Alan Silvidi 🍀 @ASilvidi68]

One month from tonight my band Fallout returns to @WaterStTavern in Kent for our annual Christmas show! If you haven’t seen us before, come out and have a great time. December 3, 7-10 pm.

[Chas Boyden @ceboyden]

@AriannaSimpson @laurashin Why do you have to be young to start a career in crypto (said the old guy, haha). "Looking for diverse pool...". Hidden Brain, "Implicit age attitudes will not reach neutrality even within the next 150 years"

[U.S. Air Force @usairforce]

⚡️ “Happy 4th of July from the U.S. Air Force”

https://t.co/XG9DKVG1fJ

[HHS Graphics & Video @GraphicsVid_hhs]

More photos of Video Production students filming the Herman Show with guest Jack McCormick.

[Whiteman AFB @Whiteman_AFB]

#DYK Whiteman has the most female pilots that it's ever had?!
Friday is #InternationalWomensDay and March is #WomensHistoryMonth
Watch the video below to see what these six pilots of the 509th have to say about serving their country and inspiring girls everywhere. @PilotB2

[Hudson Athletics @HudsonOHSports]

New Story: Jay Boyden - Athlete of the Week https://t.co/v06c5UysxC

[U.S. Air Force @usairforce]

A @28thBombWing B-1B & a @914ARW KC-135 conduct aerial refueling over the U.S. on Dec. 10. The #Lancer serves as premier platform for long-range bomber force, carrying the largest conventional payload of guided & unguided weapons in the #AirForce (#USAF photo/ SSgt Williams)

[Brian Wilch @BDWilch]

Host Explorer Bowlers taking on Suburban League foe N Royalton at Sto-Kent Lanes! Sr Jay Boyden rolls a another STRIKE! #RollHud!

[Steve Gibson @SGgrc]

Paypal's Venmo API defaults to publicly posting transaction details. What?!?!

This link will show you the most recent one: https://t.co/qiWgXWREr1

[Cannabis Biz Times @CBTmag]

Cannabis Business Times' graphic designer, Katelyn Boyden, attended ASBPE’s 2018 B2B Media Success Conference and Azbee Awards of Excellence Banquet May 10-11 in Washington, DC, where CBT won Magazine of the Year and a National Gold Award for its April 2017 cover story. @ASBPE