Cellecta, Inc.

Cellecta provides products & services for the discovery of therapeutic targets and specializes in pooled CRISPR & RNAi screening to identify cancer drug targets

[Cellecta, Inc. @CELLECTA]

RNA or DNA for immune repertoire profiling? The answer starts with what you need to measure.

Read Cellecta's explainer on clonotype representation, receptor expression, and choosing a sample approach for your study.

https://t.co/e6ZcqJlxB1

#ImmuneRepertoire #Immunology #TCR #BCR #cellecta

[Cellecta, Inc. @CELLECTA]

How do individual cells respond to a gene perturbation? Single-cell CRISPR workflows connect guide identity with gene-expression measurements.

Read Cellecta's explainer on Perturb-Seq and CROP-Seq studies.

https://t.co/p2AaI32xK0

#SingleCell #CRISPR

[Cellecta, Inc. @CELLECTA]

Cell populations can respond unevenly to the same gene perturbation.

Single-cell CRISPR screening connects a perturbation with the transcriptional response measured in individual cells. That can help researchers examine how responses differ across a mixed population.

Cellecta's CRISP-Seq barcoded sgRNA libraries support linking guide identity with single-cell expression measurements. This explainer introduces the approach for Perturb-Seq and CROP-Seq workflows.

Read it with your study in mind: which cell states or expression responses would you want to distinguish?

https://t.co/ycikrqSyGk #SingleCell #CRISPR #PerturbSeq

[Cellecta, Inc. @CELLECTA]

At AMP in Seattle this week?

Join Cellecta's workshop on mapping antigen-specific T- and B-cell clonotypes for receptor-based target discovery.

Wednesday, November 11
2:00–2:50 p.m. Seattle local time
Tahoma 5, Level 3, Arch at 800 Pike

The workshop brings a research focus to questions about receptor repertoires and antigen-specific clonotypes.

You can also meet the Cellecta team at Booth 2205 during the expo, November 12–14.

View the workshop and event information: https://t.co/EFxWwvvNKQ

#AMP2026 #MolecularPathology #Immunology

[Cellecta, Inc. @CELLECTA]

Planning a CRISPR screen? Start with the response you want to measure.

Cellecta supports targeted and genome-wide screens with viability and FACS-based selection options. Explore how the cell model, perturbation, and readout can fit your research question.

https://t.co/DvWwxS0AnN

#CRISPR #FunctionalGenomics

[Cellecta, Inc. @CELLECTA]

Cellecta’s CloneTracker™ XP Barcode Libraries and Kits use stable, heritable, sequenceable barcodes to label individual cells and follow their clonal descendants over time. This enables researchers to study how distinct cell populations respond to treatment, selection, differentiation, disease progression, and other experimental conditions.

With CloneTracker™ XP Barcode Libraries and Kits, researchers can:

• Assess changes in cell-population heterogeneity
• Identify clones that persist or expand under selective pressure
• Compare clonal responses across different conditions
• Track changes in cellular diversity over time
• Quantify barcodes using genomic DNA sequencing, with select CloneTracker XP™ configurations also compatible with RNA-Seq analysis

Follow your cells' fate and uncover the clonal dynamics behind their response.

Learn more about CloneTracker™ Barcode Libraries: https://t.co/dqfi5zUp5k

#CloneTracker #CellBarcoding #ClonalTracking #CellBiology #Genomics #NGS #RNASeq #DrugResistance #CancerResearch #LifeSciences #Cellecta

[Cellecta, Inc. @CELLECTA]

With 𝗖𝗲𝗹𝗹𝗲𝗰𝘁𝗮’𝘀 𝗖𝗲𝗹𝗹 𝗘𝗻𝗴𝗶𝗻𝗲𝗲𝗿𝗶𝗻𝗴 𝗦𝗲𝗿𝘃𝗶𝗰𝗲𝘀, you can go beyond standard tools and create cell lines tailored to your experiments—whether you need Cas9/dCas9 expressing cells for a CRISPR screen or are developing specialized functional models.

What we offer:
• Gene knockouts or targeted knock-ins
• Ready-made or custom Cas9/dCas9 lines
• Specialized cell models for infection and pathway studies

Your project, your specs—our expertise.

Learn more: https://t.co/t1W67tZI7i

#CellEngineering #CRISPR #Cas9 #dCas9 #GeneticScreen #GeneEditing #CustomCellLines #FunctionalGenomics #Cellecta #BiotechServices

[Cellecta, Inc. @CELLECTA]

Cellecta’s Single-Cell CRISPR Screening Service combines pooled CRISPR perturbations with 10X Chromium scRNA-Seq to reveal how individual gene edits influence cellular transcriptional profiles.

Key capabilities:
• Profile 100+ gene perturbations in a single experiment
• Support CRISPR knockout, CRISPRi, and CRISPRa applications
• Identify gene networks and cellular pathways that may be missed with bulk screening

From gene discovery to pathway analysis, our end-to-end service helps you gain deeper insights into complex biological systems.

Learn more at: https://t.co/F1dgXdGoIM #SingleCellCRISPR

#PerturbSeq #CROPSeq #CRISPR #scRNASeq #FunctionalGenomics #GeneEditing #Cellecta

[Cellecta, Inc. @CELLECTA]

𝗖𝗲𝗹𝗹-𝗳𝗿𝗲𝗲 𝗻𝘂𝗰𝗹𝗲𝗶𝗰 𝗮𝗰𝗶𝗱𝘀 𝗼𝗳𝗳𝗲𝗿 𝗮 𝘂𝗻𝗶𝗾𝘂𝗲 𝗼𝗽𝗽𝗼𝗿𝘁𝘂𝗻𝗶𝘁𝘆 𝘁𝗼 𝘀𝘁𝘂𝗱𝘆 𝗶𝗺𝗺𝘂𝗻𝗲 𝗮𝗰𝘁𝗶𝘃𝗶𝘁𝘆 without relying solely on tissue biopsies.

Insight into cfDNA and cfRNA is important:
• cfDNA reflects immune cell turnover associated with apoptosis and necrosis.
• cfRNA, including RNA within extracellular vesicles, reflects activated T- and B-cells secreted into plasma or T-/B-cells. Together, these biomarkers provide complementary insights into immune dynamics and tissue-associated immune responses.

View the full poster: https://t.co/52GnGHoFQ6

#LiquidBiopsy #ImmuneMonitoring #DriverMapAIR #Immunology #FunctionalGenomics #Cellecta

[Cellecta, Inc. @CELLECTA]

Cellecta's findings demonstrate that 𝗰𝗹𝗼𝗻𝗼𝘁𝘆𝗽𝗲𝘀 𝗱𝗲𝘁𝗲𝗰𝘁𝗲𝗱 𝗶𝗻 𝗰𝗶𝗿𝗰𝘂𝗹𝗮𝘁𝗶𝗻𝗴 𝗰𝗲𝗹𝗹-𝗳𝗿𝗲𝗲 𝗻𝘂𝗰𝗹𝗲𝗶𝗰 𝗮𝗰𝗶𝗱𝘀 𝗼𝘃𝗲𝗿𝗹𝗮𝗽 𝘄𝗶𝘁𝗵 𝘁𝗵𝗼𝘀𝗲 𝗳𝗼𝘂𝗻𝗱 𝗶𝗻 𝗺𝗮𝘁𝗰𝗵𝗲𝗱 𝗙𝗙𝗣𝗘 𝘁𝘂𝗺𝗼𝗿 𝘁𝗶𝘀𝘀𝘂𝗲 from NSCLC and melanoma samples.

Our work also showed:
✔ Shared clonotypes between circulating cfNA and tumor tissue
✔ Detection of both TCR and BCR clonotypes across sample types
✔ The potential of cfNA immune repertoire profiling as a minimally invasive approach for response monitoring during immunotherapy

Learn more. Check out the poster: https://t.co/52GnGHoFQ6

#Immunotherapy #DriverMapAIR #LiquidBiopsy #CancerResearch #ImmuneProfiling #Cellecta

[Cellecta, Inc. @CELLECTA]

Looking for an expert partner for your next CRISPR screen?

Cellecta proven products support every stage of functional genetic screening—from pooled library design through full genome-wide screening to extensive data analysis.

Purchase one of the libraries below:
• CRISPR Knockout Libraries (including the new 43K & 87K genome-wide libraries)
• CRISPRa/CRISPRi Libraries
• CRISPR-Seq Barcoded Libraries
• RNAi shRNA Libraries
• Custom Pooled Lentiviral Libraries
• CloneTracker™ XP Barcode Librarie

https://t.co/LBSuSNb3N8

#CRISPRScreening #FunctionalGenomics #DrugDevelopment #CancerResearch #Cellecta

[Cellecta, Inc. @CELLECTA]

𝗪𝗮𝗻𝘁 𝗲𝗮𝗿𝗹𝘆 𝗮𝗰𝗰𝗲𝘀𝘀 𝘁𝗼 𝗿𝘂𝗻 𝗧𝗖𝗥- 𝗼𝗿 𝗕𝗖𝗥-𝗦𝗲𝗾 𝗼𝗻 𝗽𝗹𝗮𝘀𝗺𝗮 𝘀𝗮𝗺𝗽𝗹𝗲𝘀?

𝗖𝗲𝗹𝗹𝗲𝗰𝘁𝗮'𝘀 𝗗𝗿𝗶𝘃𝗲𝗿𝗠𝗮𝗽 𝗰𝗲𝗹𝗹-𝗳𝗿𝗲𝗲 𝗻𝘂𝗰𝗹𝗲𝗶𝗰 𝗮𝗰𝗶𝗱 (𝗰𝗳𝗗𝗡𝗔 +𝗰𝗳𝗥𝗡𝗔) 𝗮𝗱𝗮𝗽𝘁𝗶𝘃𝗲 𝗶𝗺𝗺𝘂𝗻𝗲 𝗿𝗲𝗰𝗲𝗽𝘁𝗼𝗿 𝗽𝗿𝗼𝗳𝗶𝗹𝗶𝗻𝗴 (𝗰𝗳𝗔𝗜𝗥) 𝗮𝘀𝘀𝗮𝘆 extends immune repertoire profiling beyond traditional tissue and PBMC samples by analyzing cell-free DNA (cfDNA), cell-free RNA (cfRNA), and extracellular vesicles (EVs) from plasma. Key advantages of this assay include:
✔ Optimized for fragmented nucleic acids
✔ Single-tube multiplex workflow
✔ Comprehensive profiling of all TCR and BCR receptor chains
✔ Sensitive detection from as few as 10 template molecules

Learn more by viewing the poster: https://t.co/52GnGHo80y

𝗗𝗼 𝘆𝗼𝘂 𝗵𝗮𝘃𝗲 𝗽𝗹𝗮𝘀𝗺𝗮 𝘀𝗮𝗺𝗽𝗹𝗲𝘀? Want 𝗲𝗮𝗿𝗹𝘆 𝗮𝗰𝗰𝗲𝘀𝘀 to this technology? 𝗘𝗺𝗮𝗶𝗹 𝘂𝘀 𝘁𝗼𝗱𝗮𝘆 𝗮𝘁 𝗰𝗼𝗹𝗹𝗮𝗯𝗼𝗿𝗮𝘁𝗲@𝗰𝗲𝗹𝗹𝗲𝗰𝘁𝗮.𝗰𝗼𝗺

#DriverMapAIR #LiquidBiopsy #ImmuneProfiling #TCRSeq #BCRSeq #FunctionalGenomics #Cellecta

[Cellecta, Inc. @CELLECTA]

Published Research Spotlight 🧬🔬

A recent 𝘊𝘢𝘯𝘤𝘦𝘳 𝘙𝘦𝘴𝘦𝘢𝘳𝘤𝘩 study used 𝗖𝗲𝗹𝗹𝗲𝗰𝘁𝗮’𝘀 𝗖𝗹𝗼𝗻𝗲𝗧𝗿𝗮𝗰𝗸𝗲𝗿™ 𝗫𝗣 𝗟𝗲𝗻𝘁𝗶𝘃𝗶𝗿𝗮𝗹 𝗘𝘅𝗽𝗿𝗲𝘀𝘀𝗲𝗱 𝗕𝗮𝗿𝗰𝗼𝗱𝗲 𝗟𝗶𝗯𝗿𝗮𝗿𝘆 to follow clonal dynamics in a pancreatic ductal adenocarcinoma (PDAC) model in vivo. Researchers barcoded KPC tumor cells, introduced either control or Dpy30-targeting sgRNAs, transplanted the cells into immunodeficient and immunocompetent mice, and then analyzed barcode representation by NGS.

The results revealed a striking depletion of Dpy30-KO barcoded clones in immunocompetent mice, accompanied by increased tumor-infiltrating lymphocytes. Additional experiments supported a key role for CD8+ T cells in clearing DPY30-deficient tumor cells.

More broadly, the study found that loss of DPY30 destabilized stressed replication forks, promoted genomic instability and inflammation, and increased sensitivity to immune checkpoint blockade. In the preclinical anti–PD-1 experiments, 60% of mice bearing Dpy30-KO tumors showed complete tumor regression.

𝗧𝗵𝗶𝘀 𝘄𝗼𝗿𝗸 𝗵𝗶𝗴𝗵𝗹𝗶𝗴𝗵𝘁𝘀 𝗵𝗼𝘄 𝗰𝗲𝗹𝗹 𝗯𝗮𝗿𝗰𝗼𝗱𝗶𝗻𝗴 𝗮𝗻𝗱 𝗰𝗹𝗼𝗻𝗮𝗹 𝘁𝗿𝗮𝗰𝗸𝗶𝗻𝗴 𝗰𝗮𝗻 𝗵𝗲𝗹𝗽 𝗿𝗲𝘃𝗲𝗮𝗹 𝗰𝗼𝗻𝘁𝗲𝘅𝘁-𝗱𝗲𝗽𝗲𝗻𝗱𝗲𝗻𝘁 𝘁𝘂𝗺𝗼𝗿 𝗿𝗲𝘀𝗽𝗼𝗻𝘀𝗲𝘀 𝘁𝗵𝗮𝘁 𝗺𝗶𝗴𝗵𝘁 𝗼𝘁𝗵𝗲𝗿𝘄𝗶𝘀𝗲 𝗯𝗲 𝗱𝗶𝗳𝗳𝗶𝗰𝘂𝗹𝘁 𝘁𝗼 𝘂𝗻𝗰𝗼𝘃𝗲𝗿.

Read the Full Publication Here 👉 https://t.co/RavSn4k5lV

Or learn more about how clonal barcoding can help accelerate your discovery. https://t.co/7RwaXTjH37

#CloneTracker #ClonalTracking #CellBarcoding #CancerResearch #PancreaticCancer #PDAC #Immunotherapy #FunctionalGenomics #NGS #Cellecta

[Cellecta, Inc. @CELLECTA]

Using a modified DriverMap™ AIR workflow, 𝗖𝗲𝗹𝗹𝗲𝗰𝘁𝗮 𝗽𝗿𝗼𝗳𝗶𝗹𝗲𝗱 𝗰𝗲𝗹𝗹-𝗳𝗿𝗲𝗲 𝗗𝗡𝗔 & 𝗥𝗡𝗔 𝗮𝗱𝗮𝗽𝘁𝗶𝘃𝗲 𝗶𝗺𝗺𝘂𝗻𝗲 𝗿𝗲𝗽𝗲𝗿𝘁𝗼𝗶𝗿𝗲𝘀 (𝗗𝗿𝗶𝘃𝗲𝗿𝗠𝗮𝗽 𝗰𝗳𝗔𝗜𝗥) 𝗳𝗿𝗼𝗺 𝗽𝗹𝗮𝘀𝗺𝗮 𝘀𝗮𝗺𝗽𝗹𝗲𝘀 collected from healthy donors and patients with NSCLC, melanoma, and hepatocellular carcinoma.

Study highlights:
✔ Thousands of clonotypes detected in matched plasma-FFPE tissue samples
✔ cfRNA demonstrated greater sensitivity in detecting clonotypes than cfDNA alone
✔ Both T-cell and B-cell receptor clonotypes were detected across multiple sample types

Read the full poster: https://t.co/52GnGHoFQ6

Do you have plasma samples? Are you interested in TCR- or BCR- repertoire profiling? Reach out at [email protected]

#DriverMapAIR #CancerResearch #LiquidBiopsy #ImmuneProfiling #TCRSeq #BCRSeq #Cellecta

[Cellecta, Inc. @CELLECTA]

Unlock deeper insights with functional genetic screening. 🧬

Using CRISPR or RNAi libraries combined with bioinformatics analysis, Cellecta can help researchers uncover the genetic drivers behind complex biological responses, including:
• Identifying mechanisms of action and synergistic drug targets
• Understanding complex phenotypes such as differentiation, senescence, infection, oncogenesis, and metastasis
• Mapping genetic mechanisms involved in drug resistance
• Discovering new pathways and potential therapeutic targets

Ready to explore what functional screening could reveal in your research?

Contact Cellecta to discuss your specific CRISPR or RNAi screening needs. 🔗 https://t.co/DvWwxS0AnN #CRISPR #RNAi #GeneticScreening #FunctionalGenomics #DrugDiscovery #Bioinformatics #Genomics #LifeSciences #Biotech #Research

[Cellecta, Inc. @CELLECTA]

Streamline your CRISPR workflow with Cellecta’s Cas9-Expressing Cell Line Service. From selecting your Cas9 variant to delivering fully validated cells with Cas9 activity data—we handle every step for you.

For faster results, you may want to check out our off-the-shelf, ready-to-use, f𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝗮𝗹𝗹𝘆 𝘃𝗮𝗹𝗶𝗱𝗮𝘁𝗲𝗱 Cas9-expressing cell lines: https://t.co/X5jYa5Gez8

Proven results: Reliable Cas9 copy number and knockout efficiency give your experiments the strongest foundation.

Get started today: https://t.co/XfCRNzfPfS

#Cas9 #CRISPRTools #CellEngineering #FunctionalGenomics #Cellecta

[Cellecta, Inc. @CELLECTA]

Track cells. Follow clones. Uncover what changes.

Cellecta’s CloneTracker™ XP Barcode Libraries and Kits let researchers label large cell populations with stable, heritable, sequenceable barcodes, helping them follow individual clones and their descendants through treatment, differentiation, disease progression, and other experimental conditions.

CloneTracker™ can help researchers:
• Assess changes in cell population heterogeneity
• Identify clones that survive drug treatment or other selection pressures
• Track cell diversity during differentiation or disease progression
• Quantify barcoded populations using genomic DNA sequencing, with select CloneTracker XP™ configurations also compatible with RNA-Seq analysis

Give every clone an identity and see where the science takes it.

Learn more about CloneTracker™ Barcode Libraries and Kits: https://t.co/UvDZLt87ob

#CloneTracker #CellBarcoding #ClonalTracking #Genomics #CellBiology #DrugResistance #CancerResearch #RNASeq #LifeSciences #Cellecta

[Cellecta, Inc. @CELLECTA]

Cellecta's DriverMap™ AIR TCR–Antigen Discovery Workflow brings together the tools needed to identify, reconstruct, and validate antigen-specific T-cell receptors in one streamlined process.

Our workflow supports:
✔ Bulk TCR repertoire sequencing
✔ Single-cell α/β chain-pair recovery
✔ Functional testing with Jurkat TCR reporter cells
✔ Antigen validation using K562 APC co-culture

By connecting each stage of TCR discovery, researchers can move more efficiently from sequencing data to validated biological insights.

🔗 Learn more:
https://t.co/XPRf0Ef6h1

#Immunotherapy #TCR #DriverMapAIR #SingleCellSequencing #CancerResearch #FunctionalGenomics #Cellecta

[Cellecta, Inc. @CELLECTA]

Every experiment is different—which is why Cellecta offers Custom Lentiviral Barcode Libraries tailored to your specific research goals.

Whether you're studying lineage relationships, clonal evolution, or cell population dynamics, our custom libraries provide:

✔ Millions of unique barcode sequences
✔ Stable, heritable genomic integration
✔ DNA- and RNA-based barcode detection
✔ Flexible vector, marker, and selection options

If our standard libraries don't meet your needs, we'll work with you to create a custom solution.

🎉 Limited-time offer: Buy one qualifying library and receive 30% off one screening support product with code BLG30.

Learn more:
https://t.co/LBSuSNb3N8

#BarcodeLibraries #CloneTracking #FunctionalGenomics #CRISPR #LentiviralLibraries #Cellecta

[Cellecta, Inc. @CELLECTA]

Every experiment is different—which is why Cellecta offers Custom Lentiviral Barcode Libraries tailored to your specific research goals.

Whether you're studying lineage relationships, clonal evolution, or cell population dynamics, our custom libraries provide:

✔ Millions of unique barcode sequences
✔ Stable, heritable genomic integration
✔ DNA- and RNA-based barcode detection
✔ Flexible vector, marker, and selection options

If our standard libraries don't meet your needs, we'll work with you to create a custom solution.

🎉 Limited-time offer: Buy one qualifying library and receive 30% off one screening support product with code BLG30.

Learn more:
https://t.co/LBSuSNavXA

#BarcodeLibraries #CloneTracking #FunctionalGenomics #CRISPR #LentiviralLibraries #Cellecta