This was one of those experiments where we thought there was no effect, or a tiny effect, because we grouped the male and female data together.
Separating the groups by sex revealed that exercise was benefitting female mice, but not male mice.
Our newest preprint shows sex specific effect of exercise on motor coordination and dopamine neuron excitability! This was actually really surprising to us.
https://t.co/IHS4HHJJGn
We find that chronic nicotine, when administered to adult mice, decreases dopaminergic neuron spontaneous firing rate and rebound activity. These effects could protect the neurons by decreasing their metabolic load.
The reason for this is that nicotine's protective effects seem to be only preventative, in that it reduces the risk of developing Parkinson's, but doesn't have a therapeutic effect on symptoms or disease progression after diagnosis.
Our lab has 2 great posters at #SfN25 this year! Plus a collaborative poster. Come see us Wednesday afternoon to learn how brainstem connections process sensory stimuli.
Excited to share our version of record in eLife! We find that two ways of inhibiting a brainstem structure (PPN) actually result in completely different and even opposite behaviors. One inhibitory connection is rewarding and one is aversive. https://t.co/jvawy8TqSI
@DautanDaniel Thanks! We actually show that the snc projections, not the snr input increase movement (see supplemental figures), and likely through antidromic stimulation, not through actions in the PPN. However, the rewarding and aversive effects don't appear to require antidromic activation
Exciting work from the lab on unique DA subpopulation! SN pars lateralis DAN firing differs from SNc in super interesting ways. We find robust auditory CTX input and test in threat behavior. Congrats to Lorenzo Sansalone (@newrochemist), @cellularscale@e_twedell, Sherry Zhang!
"Female academics also have disproportionately fewer Twitter followers, likes and retweets than their male counterparts, regardless of their Twitter activity levels or professional rank."
https://t.co/WKVup55HGV
It's time to change this. Let's make today #FollowWomen day!
Michel Fallah, from the lab of 2023 Stanley Fahn Awardee @cellularscale, presented her meticulous physiology work on the differential inhibitory inputs to PPN neuron populations. Great work!