champ_wayne

𝕴 𝖆𝖒 𝖜𝖍𝖔 𝕴 𝖆𝖒. Internist | Cardiologist | VascularMed | Associate Professor CIM | Physician with a Heart | Mentor | Friend

[champ_wayne @champ_wayne]

Me and my resident-mentees (@florgefrancis, @karlomayol, @najCarz, @IanDils) 😍

[champ_wayne @champ_wayne]

@nicolesee Proud mentor moment! BIG Congratulations to these 3 residents for placing 2nd Place in the 2026 Heart Failure Society of the Philippines Quiz Bowl!

[champ_wayne @champ_wayne]

Me and my resident-mentees (@florgefrancis, @karlomayol, @najCarz, @IanDils) 😍

[champ_wayne @champ_wayne]

@nicolesee The family has grown bigger! I am honored to be their mentor. Through the years, I am proud if what the graduates have become - Oncologist and Gastroenterologist.

[champ_wayne @champ_wayne]

"The Star of Resilience: Shining Through Adversity"

[champ_wayne @champ_wayne]

"The best way to predict the future is to create it!"
-Peter Drucker

(PSVM BOT Strat Planning 11/15/2025)

[champ_wayne @champ_wayne]

Stay safe, Cebu!🙏🏻✝️

[champ_wayne @champ_wayne]

@morenotripper08 🤗

[Philippine Heart Association @PhilHeartAssoc]

We’re proud to share another milestone for the 𝐏𝐉𝐂!
Our upgraded system now streamlines everything from DOI assignment to posting — boosting global reach with 211K+ views.
Hats off to Dr. Mighty Ramirez and the PJC Team!

[PSVM @PSVM2002]

Day 2 promises exciting sessions! Don’t miss the lectures by our invited international speakers, Dr. Pierre Abraham (France) and Dr. Enmin Yong (Singapore). Let’s keep #PULSO vibrant. See you all!

#PSVM #VascularMedicine

[PSVM @PSVM2002]

Session I: Crash course on vascular signs and symptoms, particular highlighting on extremity pain, extremity edema, non-healing wounds and ulcers, and abdominal pain.

@PSVM2002 #PSVM #PULSO #VascularMedicine

[PSVM @PSVM2002]

The Philippine Specialty Board of Vascular Medicine and @PSVM2002 welcome its new diplomates during the induction ceremonies held at EDSA Shangri-La Hotel, October 15, 2025.

#PULSO #PSVM #VascularMedicine

[PSVM @PSVM2002]

The secret is out!
Live the 7 C's towards a happy, balanced life!
-Dr. Regina Berba

@PSVM2002 #PSVM #PULSO #VascularMedicine

[PSVM @PSVM2002]

Dr. Regina Barba, the Dr. Fatima Collado Professorial Lecturer, emphasized the importance of actively maintaining balance in life rather than leaving it to chance. She elaborated on this by introducing the 7 C's as a guide to achieving work-life harmony.
#PULSO #VascularMedicine

[champ_wayne @champ_wayne]

Congratulations and welcome to @PSVM2002!

[PSVM @PSVM2002]

We are excited to exchange, discuss and collaborate at the 22nd PSVM Annual Convention and Scientific Meeting. Maki-PULSO na sa EDSA Shangri-La, Oct 15-17, 2025!

[Christ is King @ChristisKing]

In every trial, God's strength is your anchor.

[Simon Maechling @simonmaechling]

The immune system is powerful.
Sometimes, too powerful.

If it goes unchecked, it can turn on us -
attacking our own organs, tissues, even our blood.

That’s why the 2025 Nobel Prize in Medicine matters so much.

It honors three scientists who figured out how the body stops itself from self-destructing.

🧬 Mary Brunkow
🧪 Fred Ramsdell
🧫 Shimon Sakaguchi

Here’s the story :👇

Every day, your body fights off thousands of invaders - viruses, bacteria, fungi.

But the real magic? It knows not to attack you.

That precision is everything.
And for decades, scientists thought they knew how it worked:
Bad immune cells were weeded out early in the thymus (central tolerance). End of story.

Except… that wasn’t the whole story.

Sakaguchi’s bold idea (1995)

He challenged the dogma.
He found a new class of immune cells doing something unexpected:

➡️ They weren’t attacking.
➡️ They were protecting.

He called them regulatory T cells - the immune system’s peacekeepers.

They roam the body and tell other immune cells:
“Stand down. This is us. Don’t attack.”

It was a radical idea at the time. But he was right.

Brunkow & Ramsdell’s breakthrough (2001)

They were studying a mysterious mouse.
It had a single mutation - and developed devastating autoimmune disease.

They found the cause: a gene called Foxp3.
🧬 Foxp3 isn’t just any gene.

It’s the master switch that tells cells to become regulatory T cells - the same ones Sakaguchi discovered.

Mutate it in mice or humans… and the immune system spins out of control.

In kids, that mutation causes a rare and deadly disease: IPEX syndrome.
The missing link (2003)

Sakaguchi came back to close the loop.

He proved that Foxp3 is what powers the regulatory T cells - the body’s tolerance enforcers.

This confirmed the whole mechanism.

➡️ We don’t just delete dangerous immune cells early on.
➡️ We also deploy specialized cells to watch over the rest.
➡️ That’s how we avoid autoimmune chaos.

The impact? Massive.

Their discoveries opened an entire new field: peripheral immune tolerance.

We now have:

🔹 New approaches to treat autoimmune diseases
🔹 Promising advances in organ transplant tolerance
🔹 Immunotherapies that fine-tune the immune system to fight cancer - without turning on the body

Some of these are already in clinical trials.

This isn’t just a scientific triumph.
It’s a reminder that:

✅ Curiosity still drives paradigm shifts.
✅ Going against the mainstream can change everything.
✅ Basic science leads to better medicine.

And sometimes, three scientists working decades apart can quietly solve one of biology’s deepest mysteries.

👉 That’s worth a Nobel.

[champ_wayne @champ_wayne]

Big Congratulations! @HankyDoodle__ @CMLoquere
Your #ChongHuaHospital #VascularMedicineFamily are so proud of you!
#CHH💯 @PSVM2002

[champ_wayne @champ_wayne]

What do we need to do?

@SVM_tweets @PSVM2002 @VMJ_SVM

[champ_wayne @champ_wayne]

Renal Denervation Therapy

@SVM_tweets @PSVM2002

[Muthu Vaduganathan @mvaduganathan]

Outpatient Worsening HF (Oral Diuretic Intensification)
☑️ Frequent
☑️ Prognostically meaningful
☑️ Temporally precedes 🏥
☑️ Similar treatment effect sizes #GDMT as those on 🏥

Building evidence for its role in broader composite esp in lower-risk CKM pts
https://t.co/pJPiy2b7u7

[Dr. Martha Gulati ♥️🫀❤️‍🩹🇨🇦 @DrMarthaGulati]

@mvaduganathan concludes the Lancet discussion on #HFPrevention:
🫀 HF mortality increasing and gains reversing
🫀 we have the tools 🧰 to prevent (and our @JCardFail @AJPCardio paper was also mentioned)
#ESCongress #WCCongress #functionnotfailure