Preprint from Dario Alessi lab identifying many new #LRRK2 variants linked to #Parkinson’s - some lying outside of the catalytic domain - that activate kinase activity. @ASAP_Research https://t.co/F57Dq3tc08
Preprint from the Alessi lab identifying many new #LRRK2 variants linked to #Parkinsons - some lying outside of the catalytic domain - that activate kinase activity https://t.co/gOrpAUtXna
The first datasets from our degradation proteomics initiative were sent out over the last few weeks!! 🎉
If you’re interested in free global proteomics screening of degraders for target ID and mapping please get in touch and I can provide further details.
Call for papers: submit your work on emerging high-throughput technologies for tool compound discovery/validation now!!!
We are interested in a range of topics, so check it out: https://t.co/nvKZ5c1YDR
Our new paper on mining the dark kinome with the software ProKinO is on #biorxiv. We've added a number of new tools into the ProKinO suite for mining data, including structural models generated via #AlphaFold2. #Bioinformatics#kinase#compchem#biochem
https://t.co/diCPfMR1f7
Submitted required documents for 221g form 6 weeks ago and hoping to receive my B1 US visa, in order to participate @GordonConf on autophagy (march 19-25, 2022). Earnest request to @usconsfrankfurt, to expedite #221g processing. #crucialcareerdecision. Please retweet.
Small molecule modulation of protein polymerization - a Viewpoint from Eric Fischer and myself now published in Chemical Society Reviews https://t.co/k6ved5LbzD
Delighted to contribute to new study from @v_decesare@mrcppu describing robust mass spectrometry assays for measuring #Parkin activity offering exciting new screening platform for Parkin activators #Parkinsons#therapeutics https://t.co/EPjxIzGS8f
Why Merck’s PCSK9 Inhibitors Are a Big Deal | https://t.co/LbkrKoiVuh
Merck’s oral, macrocyclic PCSK9 inhibitors have already gotten quite a few votes for 2021’s “Molecule of the Year," w/ readers calling them "gamechangers"
More details in our newly released slide deck
Who in academia/charity wants *free* pure, active PKA catalytic subunit for #kinase assays etc? Based on @SigmaAldrich price, $5 million worth to freely distribute. Can't be arsed to start a company. Please RT if reagent sharing sounds up your alley. Many other #kinases too!
Just out! Our new preprint into human #PINK1 kinase activation based on @DeepMind #AlphaFold PINK1 structure models. Uncovering new mechanisms of #Parkinsons disease. 🙏 @mrcppu lab and collaborators from @Astbury_BSL @baylisslab @DZNE_en #TeamScience https://t.co/YBcxqjuUZd