Jose Maria Restrepo

Neuroscience PhD. In pursuit of elegant, evidence-based solutions.
More than any other discipline, we should be thankful for the existence of cell biology.

[Jose Maria Restrepo @chemarestrepo]

@parmita Your words, not mine

[Jose Maria Restrepo @chemarestrepo]

@parmita

[Jose Maria Restrepo @chemarestrepo]

@parmita Happy birthday by the way, I hope you achieve all your goals!

[Cell @CellCellPress]

New issue alert!👉https://t.co/uP2kI6DjtL

On the cover: Brann et al. demonstrate that each olfactory sensory neuron selects one of approximately 1,000 receptors to express based on its spatial position within the olfactory epithelium, thereby creating a stereotyped receptor map

[Arc Institute @arcinstitute]

The brain works hard to clear waste, and impairments are central to neurodegeneration. In @CellCellPress, Innovation Investigator @andcyang, w/ @NaliniRRao, Yuichi Chayama, and team map it from the inside out, following the brain's own proteins to see where waste actually goes.

[Jose Maria Restrepo @chemarestrepo]

https://t.co/kX5dAJzlvW

[Jose Maria Restrepo @chemarestrepo]

@drgurner @JTLonsdale @jawwwn_ @jaltma @precigenetic They don't look at proteins though, missing a big part of the picture!

[Jose Maria Restrepo @chemarestrepo]

@parmita I mean, you say chemical imaging, but it sounds very misleading when you don't see proteins! No?

[Jose Maria Restrepo @chemarestrepo]

@BenjaminGVincen @parmita @JTLonsdale @drgurner @jawwwn_ @jaltma This is very much on point, you need tissue-level interactions too!

[Jose Maria Restrepo @chemarestrepo]

https://t.co/6mft70i0g5

[🥺ぴえんねずみ🐀🍝 @pien_nezumi]

神経細胞の長期培養ができるようになりました。
今まではDIV10-12くらいでしたけど、これはDIV28。
ここまで育てると改めて神経細胞が美しいものだと実感させられます🥺

[Jose Maria Restrepo @chemarestrepo]

@parmita If anything, I would invite you to see my questions in response to your tweets as a sign of my curiosity and interest in what you are saying

[Jose Maria Restrepo @chemarestrepo]

@parmita Well, now you know that you have a big fan here (from a while back, at least 2 years). I do hope you find my responses engaging. I firmly believe that actively trying to resolve disagreements can be a catalyst for science progress (at the very least, for refining q's)!

[Jose Maria Restrepo @chemarestrepo]

@ATinyGreenCell @parmita @TomKnightSynBio Indeed

[Jose Maria Restrepo @chemarestrepo]

@parmita I think the NanoDrop spectrophotometer is pretty spectacular. I remember how amazed I was when I realized it was possible to quantify my samples using just a couple of uL

[Jose Maria Restrepo @chemarestrepo]

@parmita @slavov_n https://t.co/Ee0Rnpqqlb

[Prof. Nikolai Slavov @slavov_n]

These numbers are key to understanding RNA and protein analysis.

The different counting statistics fundamentally shape technological challenges and opportunities.

https://t.co/UKsQ2AEuro

[Jose Maria Restrepo @chemarestrepo]

@parmita The question is why do you want to do that. Protein abundance in cells is a couple of orders of magnitude larger than RNA abundance. See recent post by @slavov_n

[Jose Maria Restrepo @chemarestrepo]

@parmita @markwbudde @JeffriesFreeway My reaction every time I read "proteins can't be PCRed" is, why on earth would you want to do such a thing? It's almost like the question itself makes little sense, PCR is a process developed for a very different type of molecule