Cherry Chengchen Li 李成辰

PhD student at NUS. Former research project manager & data analyst at Harvard Microbiome Center；Emory-Rollins, UIowa alumni.

[Cherry Chengchen Li 李成辰 @ChengchenliC]

Thrilled to share our work offering a fresh lens into the skin microbiome across body sites! Incredible support from @NiranjanTW @john_common @atViduall @aarthiravikrish @indrikwijaya @jsgounot @minghao_chia+Asian Skin Microbiome Program & the HELIOS study team! Check it out 👇

[Niranjan Nagarajan @NiranjanTW]

Super thrilled to share our labor of love from the Asian Skin Microbiome Program! Collected >3,500 skin samples, built metagenomic libraries w/ >70 billion reads and >10TB of data to study population heterogeneity in skin microbiome (200 adults, 18 sites) https://t.co/ZylbJMpvpw

[Niranjan Nagarajan @NiranjanTW]

@atVidu 5. Exciting days ahead as we try to decipher the contributions of diverse factors that shape skin microbiome dermotypes, and in turn their influence on skin health!

[Niranjan Nagarajan @NiranjanTW]

@atVidu 4. Dermotypes exhibit distinct associations w/ host, where ethnicity and gender play a role in some cases, while others are linked to skincare behaviors. Skin sensitivity, itch and eczema may be affected by dermotype function, highlighting utility for patient stratification & Tx

[Niranjan Nagarajan @NiranjanTW]

3. Microbes behave very differently across dermotypes in terms of who they co-occur with! We can confirm this with culture-based experiments that show that oxygen gradients and nutrient availability likely shape why we see distinct dermotypes in various individuals. @atVidu

[Niranjan Nagarajan @NiranjanTW]

2. Dermotypes are highly coordinated across sites. For some sites, we can predict the dermotype just by knowing dermotype of another site. Left and right sides of the body are also highly correlated, suggesting that individual intrinsic factors strongly shape the skin microbiome.

[Niranjan Nagarajan @NiranjanTW]

Many exciting results to follow-up on!
1. The skin microbiome has unique “types” in every site - we call them dermotypes. The underarm has as many as 5 distinct ones defined by diverse microbes. We built ML classifiers to predict them w/ near-perfect accuracy with 5 species!

[Niranjan Nagarajan @NiranjanTW]

Super thrilled to share our labor of love from the Asian Skin Microbiome Program! Collected >3,500 skin samples, built metagenomic libraries w/ >70 billion reads and >10TB of data to study population heterogeneity in skin microbiome (200 adults, 18 sites) https://t.co/ZylbJMpvpw

[Niranjan Nagarajan @NiranjanTW]

Ever wondered what genes/pathways skin microbes are using in vivo? Are some microbes even transcriptionally active?

We have developed a minimally-invasive protocol to robustly assay gene expression in the skin microbiome in vivo! Check out our preprint: https://t.co/HXK3JshMs0

[Niranjan Nagarajan @NiranjanTW]

Tech Alert! 🚀🧬 We can now determine the sequence of DNA with non-canonical bases in a direct and high-throughput manner with Nanopore sequencing. Check out our preprint for details: https://t.co/mSOSzubouc

[Cherry Chengchen Li 李成辰 @ChengchenliC]

@hutlab Thank you 😊 ! Will miss everyone in hutlab !

[hutlab @hutlab]

Congratulations to Cherry on her next career adventure! Cherry will start a PhD training to make more preparation for her academic career. Good luck and best wishes for Cherry!

[Harvard Chan Microbiome in Public Health Center @HCMPHmicrobiome]

We’re hiring a Microbiome Collection Core Manager https://t.co/FUqW9PQypu for our microbiome sample collection core facility https://t.co/c96rPn0jf7 -- please RT!

[hutlab @hutlab]

We're hiring! If you're interested in microbiome work, read about our latest job opening here for Microbiome Collection Core Manager: https://t.co/TYj8GsJCgL

Please tell your friends / RT!

[hutlab @hutlab]

If you're interested in #microbiome work, we're hiring! Read about our latest job openings here, for multiple postdoctoral positions as well as a senior scientist / group leader: https://t.co/jyRfpkwwXR

Tell your friends / RT!

[Jack Ma @JackMa]

Friends,

Hospitals in outbreak countries will face huge challenges coping with the surge of patients. The clinical practitioners on the front lines of China’s fight against COVID-19 have developed a handbook of treatment and care protocols for healthcare providers. (1/2)

[Jack Ma @JackMa]

I need your help to share this handbook quickly to hospitals, doctors, nurses and anyone who needs to know around the world. It is available here: https://t.co/WfQEbdmgym. We are in this together! (2/2)