Christoph Mark

Trader, Researcher, always searching for patterns. Posts are not financial advice.

[Christoph Mark @christophmark_]

Last week was a good week to invest the new strategic certificate by Artifact Research, in collaboration with Fortezza Finanz AG and @Vontobel ! 💹🚀

WKN: VJ1AWY
ISIN: DE000VJ1AWY5

The certificate dynamically invests in stock indices, treasuries, gold and commodities - all powered by Artifact Research's Bayesian algorithm.

Our philosophy: We cannot predict the future, but we can detect stable regimes that indicate the outperformance of certain asset classes.

See the link below for further info.

[Christoph Mark @christophmark_]

So OpenAI‘s new, unpublished model wanted to score well on a benchmark, and decided to break out of its sandbox and hack Huggingface‘s servers to obtain the solutions to the benchmark tasks??

Human-built cyber security isn‘t really that good after all, is it?

[OpenAI @OpenAI]

We're partnering with @huggingface to investigate an unprecedented security incident.

Cyber-capable OpenAI models compromised Hugging Face production during a benchmark evaluation.

Sharing preliminary findings to help defenders understand emerging risks:

https://t.co/CIor15y9xk

[Christoph Mark @christophmark_]

@RaminNasibov Serious Sam

[Christoph Mark @christophmark_]

Automatic unit conversion is a great idea, especially for temperature; really hard keeping both temperature scales in mind for some reason

[@levelsio @levelsio]

Mini feature idea for @nikitabier

It'd be nice if X could auto-translate metric system to imperial like 30°C to 86°F and vice versa

That'd make conversations even more international and understandable for everyone, and I wouldn't have to tweet like this :D

[Christoph Mark @christophmark_]

„Racoon in a server room at 2am“ 😂 Brilliant!

[Theo - t3.gg @theo]

I asked Fable to roast me based on one of my older codebases. It kinda cooked me.

[Mushtaq Bilal, PhD @MushtaqBilalPhD]

Sci-Hub is an evil website that pirated 85M+ research papers and made them freely available

And now they've added AI to their database to make Sci-Bot.

It answers your questions using latest, full-text articles.

But DO NOT use it. We should all try to make billion-dollar academic publishers richer.

I'm putting the link below so you know how to avoid it.

[Christoph Mark @christophmark_]

@systematicls Noticed that on /loop prompts the answers are so much shorter and much less effort, unless you reeeaally enforce it in the prompt.

[Christoph Mark @christophmark_]

Really interesting studies: apparently series of astronomical photo plates that were used to map stars in the 1950s show short light flashes like from reflections of today‘s satellites… but we didn’t have satellites back then! 🤔🛰️👽

[Beatriz Villarroel @DrBeaVillarroel]

What a lovely surprise this morning! ☀️Independent detections of similar transients in European plate archives — exactly the kind of cross-validation this field needs. So it’s not just Palomar anymore.

The study was carried out by a retired NASA scientist.
This is how a signal begins to emerge from the noise.

https://t.co/5Gq8HLm0u5

[Christoph Mark @christophmark_]

@xoo1444 Neutrophils can migrate very fast as well, comparable to NK cells! Compared to cancer cells, immune cells migrate about 20x-100x faster.

[Christoph Mark @christophmark_]

🚨 New paper is out in PNAS 🚨

Immune cells employ intermittent integrin-mediated traction forces for 3D migration

We challenge the long-held notion that immune cells migrate through tissues without gripping the surrounding matrix, relying on a friction-based amoeboid migration mode. We show that when they face tight spaces within 3D matrices, human NK cells—as well as neutrophils, monocytes, B, and T cells—briefly switch gears: they engage integrin adhesions and generate short bursts of contractile force to deform the local microenvironment. Importantly, these intermittent, acto-myosin driven traction bursts are tightly related to the fraction of cells that become stuck in narrow matrix pores. Our findings revise the prevailing view of 3D leukocyte locomotion and suggest that tuning adhesion and cytoskeletal pathways could enhance immune infiltration of dense tissues and inform combinatorial cancer therapies.

🔗 Links to article below.

[Christoph Mark @christophmark_]

@xoo1444 yeah, these ex-vivo expanded NK cells are very fast migrating cells! what cells are you working with?

[Christoph Mark @christophmark_]

I love such physics-inspired games! I think it‘s because our brains immediately start to predict what will happen next because they‘re used to predict basic mechanics stuff in every day life all the time! Very cool prototype!

[Freya Holmér @FreyaHolmer]

been feeling kinda stressed lately so I made a little prototype

is this anything

[Christoph Mark @christophmark_]

🚨 New paper is out in PNAS 🚨

Immune cells employ intermittent integrin-mediated traction forces for 3D migration

We challenge the long-held notion that immune cells migrate through tissues without gripping the surrounding matrix, relying on a friction-based amoeboid migration mode. We show that when they face tight spaces within 3D matrices, human NK cells—as well as neutrophils, monocytes, B, and T cells—briefly switch gears: they engage integrin adhesions and generate short bursts of contractile force to deform the local microenvironment. Importantly, these intermittent, acto-myosin driven traction bursts are tightly related to the fraction of cells that become stuck in narrow matrix pores. Our findings revise the prevailing view of 3D leukocyte locomotion and suggest that tuning adhesion and cytoskeletal pathways could enhance immune infiltration of dense tissues and inform combinatorial cancer therapies.

🔗 Links to article below.

[Christoph Mark @christophmark_]

Direct link to PDF: https://t.co/FUHZxOckgE

[Christoph Mark @christophmark_]

Link to PNAS: https://t.co/Ig2OFof5hq

[Christoph Mark @christophmark_]

Been doing this via ttyd and tmux for the last two weeks, will be so much more convenient now!!

[Noah Zweben @noahzweben]

Announcing a new Claude Code feature: Remote Control. It's rolling out now to Max users in research preview. Try it with /remote-control

Start local sessions from the terminal, then continue them from your phone. Take a walk, see the sun, walk your dog without losing your flow.

[Christoph Mark @christophmark_]

Working with Claude Code and Opus 4.6 the last few days, I must say this article probably describes the current state of AI and its path forward very accurately. Interesting times!

[Matt Shumer @mattshumer_]

https://t.co/ivXRKXJvQg

[Christoph Mark @christophmark_]

Last week was a good week to invest the new strategic certificate by Artifact Research, in collaboration with Fortezza Finanz AG and @Vontobel ! 💹🚀

WKN: VJ1AWY
ISIN: DE000VJ1AWY5

The certificate dynamically invests in stock indices, treasuries, gold and commodities - all powered by Artifact Research's Bayesian algorithm.

Our philosophy: We cannot predict the future, but we can detect stable regimes that indicate the outperformance of certain asset classes.

See the link below for further info.

[Christoph Mark @christophmark_]

Note the usual disclaimer: This is not financial advice, past returns do not predict future returns.

[Christoph Mark @christophmark_]

Last week was a good week to invest the new strategic certificate by Artifact Research, in collaboration with Fortezza Finanz AG and @Vontobel ! 💹🚀

WKN: VJ1AWY
ISIN: DE000VJ1AWY5

The certificate dynamically invests in stock indices, treasuries, gold and commodities - all powered by Artifact Research's Bayesian algorithm.

Our philosophy: We cannot predict the future, but we can detect stable regimes that indicate the outperformance of certain asset classes.

See the link below for further info.

[Christoph Mark @christophmark_]

https://t.co/0hx9UDf0fu