Carlo Maley

I study cancer from an evolutionary perspective including the dynamics of somatic evolution, therapeutic resistance and the evolution of cancer suppression

[Carlo Maley @cmaley]

We are excited to announce a new clinical trial - adaptive therapy for metastatic ER+ breast cancer at Mayo Clinic AZ (NCT06525766). Adaptive therapy manages the evolution of the cancer to extend survival time and reduce toxicity (improve quality of life). https://t.co/TuIgMVTrVg

[Carlo Maley @cmaley]

I'm looking forward to the big AACR Cancer Evolution conference in Albuquerque Dec. 4-6: https://t.co/XpAkt9H5ue

[Carlo Maley @cmaley]

We are hiring a postdoc to profile the evolvability of tumors in longitudinal samples from three clinical trials as part of the ARPA-H ADAPT program. This is essentially an evolutionary bioinformatics position. If you are interested, please apply here ASAP https://t.co/NtTMYBwYMA

[Carlo Maley @cmaley]

If you are interested in our research about discovering species with extremely low cancer rates or using ideas from integrated pest management to improve cancer therapy, ASU has a new podcast Lab Coat Optional that featured my work in an episode: https://t.co/WE28hWSKLi

[Carlo Maley @cmaley]

@LetsTalkFngC We are researching what we can learn about preventing and treating cancer through studying other animals (e.g. elephants). As part of our project we would like to have patient advocates and science communicators involved. Would you be interested?

[Carlo Maley @cmaley]

We just published a review of lessons farmers have learned for how to control pesticide resistance from evolving, and how to apply those to oncology to prevent cancers from evolving therapeutic resistance: https://t.co/G4Mu3mt2yY

[Carlo Maley @cmaley]

We are excited to announce that a 10 year project to gather and analyze veterinary necropsy data to discover cancer prevalence across (292) vertebrate species has finally been published open access in Cancer Discovery @aacr https://t.co/V79kF1z7ev #componc #cancer

[Carlo Maley @cmaley]

I'm going to try to migrate to Bluesky as much as possible. Please follow me there at @cmaley.bsky.social

[Carlo Maley @cmaley]

@Kevinsecto I'm trying to get in touch with you (by email or slack) about the PPF search committee. Is that something you want to do?

[Carlo Maley @cmaley]

DeGregori: This is not just a problem for cancers, but for many other disease as well #CancerEvoEco24

[Carlo Maley @cmaley]

DeGregori: Age and smoking perturb tissue leading to harmful clonal expansions that further perturb the tissue... vicious cycle #CancerEvoEco24

[Carlo Maley @cmaley]

DeGregori: Some evidence that clones with NF1 mutation make the lung more permeable to carcinogens #CancerEvoEco24

[Carlo Maley @cmaley]

DeGregori: Can treat mice with cigarette smoke (used CRISPR to inactivate particular genes in a few cells). Smoking increased the frequency of the mutant clones. Looks like knocking out NF1 led to more progenitor cells (though not sure if they are protenitors yet) #CancerEvoEco24

[Carlo Maley @cmaley]

DeGregori: Saw patient specific mutations in particular genes (may be due to individual differences in tissue level selection or to exposures) #CancerEvoEco24

[Carlo Maley @cmaley]

DeGregori: Got up to 30 different small pieces of lung tissue from the PEACE autopsies. Saw different mutations in the same gene in different locations within the same individual. #CancerEvoEco24

[Carlo Maley @cmaley]

DeGregori: Smokers have a higher fraction of lung tissue (9%) occupied by the mutations in the panel gene, compared to the never smokers (2%) #CancerEvoEco24

[Carlo Maley @cmaley]

DeGregori: Faiz Jabbar combined dN/dS with variant allele frequency as both signals of selection. TP53, Notch1, NF1, and ERBB4 were the top selected genes in the normal lung tissue - in smokers #CancerEvoEco24

[Carlo Maley @cmaley]

DeGregori: A mutation can be adaptive in a normal tissue but not contribute to malignancies (as was seen in a lot of other studies of normal tissues) #CancerEvoEco24

[Carlo Maley @cmaley]

DeGregori: The mutations that promote clonal expansion are not the mutations observed in cancer (even if you only look at COSMIC annotated mutations) #CancerEvoEco24

[Carlo Maley @cmaley]

DeGregori: Particularly in the never smokers, saw mutations in KRAS and EGFR, but not the ones that show up in the cancers #CancerEvoEco24