Kansas City is the site of a potential Messi vs. Ronaldo World Cup showdown. It's also the site of a $25.8 million, taxpayer-funded "World Cup Jail" — built by a company that constructed detainee facilities in Guantanamo Bay.
Which isn't even ready in time for the World Cup.
The Wichita Wind Surge announced they will rebrand as the Wichita Turbo Tubs.
The team says the new identity reflects the culture of Minor League Baseball.
The Turbo Tubs will replace the Wind Surge as Wichita’s permanent identity.
David's protein "ice cream" is not legal ice cream
FDA requires ice cream to have 10% milkfat. David doesn't come close
30g protein, 200 calories per pint sounds impossible because it kind of is:
- EPG, a lab-modified largely indigestible plant fat
- sweetness from sucralose and allulose
- texture from guar gum, locust bean gum, glycerin
- protein from whey isolate
A new shot literally regrows knee cartilage.
Researchers at Stanford Medicine have identified a novel strategy to regenerate articular cartilage in knees and potentially prevent or treat osteoarthritis (OA).
The method targets 15-hydroxyprostaglandin dehydrogenase (15-PGDH), an age-related enzyme—or "gerozyme"—that accumulates in aging tissues and drives degeneration.
In aged mice, small-molecule inhibitors of 15-PGDH, delivered systemically or via intra-articular injection, promoted cartilage thickening and regeneration of functional hyaline articular cartilage.
This occurred without recruiting stem or progenitor cells; instead, existing chondrocytes underwent transcriptional reprogramming to a youthful state, with reduced populations of inflammatory and hypertrophic/degradative cells and expanded matrix-producing articular chondrocytes.
The inhibitors also reversed natural age-related cartilage thinning, improved joint function, and—when administered after simulated ACL injuries—strongly mitigated post-traumatic OA progression and associated pain.
Human OA cartilage explants from total knee replacements responded similarly in vitro, showing decreased degradation markers and evidence of new articular cartilage formation.
Given that an oral 15-PGDH inhibitor has already completed Phase 1 safety trials for age-related muscle atrophy, the findings open a path toward disease-modifying, regenerative therapies that could delay or obviate the need for joint replacement surgery.
[Agarwal, P., Su, S., Ancel, S., et al. (2025). Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration. Science. DOI: 10.1126/science.adx6649]
Goldman Sachs warns curing patients is not a sustainable business model
- Gilead's hepatitis C cure caused sales crash from $12.5 billion to under $4 billion when it actually worked
- GSK sold off its entire gene therapy pipeline in 2018
- Pfizer abandoned every gene therapy program by 2025
- BioMarin pulled its hemophilia cure from the US market in Feb 2026
- Bluebird bio had three FDA approved cures and was worth $10 billion yet sold to private equity for $29 million in 2025
During this break between Kansas history posts I’m starting a new mini series on the origins of the 105 Kansas county names! There will probably be about 15 in each of these posts alphabetically over the next few weeks so enjoy!