Cristiano Mota

Structural biologist, expert in X-ray crystallography @NOVA School of Science and Technology

[UCIBIO @UCIBIO_Research]

Researchers @XTALUCIBIOFCTN1 uncover how metal-dependent formate dehydrogenase enzymes, key for CO2 reduction, are inactivated by oxygen. This discovery could pave the way for more robust bio-inspired catalysts.
More: https://t.co/9hgFOIPRlJ
#CO2Reduction #ClimateChange

[Cristiano Mota @cmota_15]

Very proud of this work by Vilela-Alves and coworkers, demonstrating at the atomic level how a W/SeCys-Fdh gets inactivated by O2.
@RoySocChem
@FCTNOVA
@UCIBIO_Research
@i4HBio
@XTALUCIBIOFCTN1
@NMRFCTNOVA1
@itqbnova
@esrfsynchrotron
https://t.co/kNZJQwBqc1

[Structural Biology Communications @ActaCrystF]

The structure of the M405S variant of the Mo/W-dependent formate dehydrogenase DvFdhAB allowed the prominent role of Met405 in the geometry of the metal site to be probed. @NovaUnl @IUCr #CO2Reduction #MetalDependentFormateDehydrogenase #MoWEnzymes https://t.co/3bEo5nL1W2

[Jan Kosinski @jankosinski]

Structure just published https://t.co/NNqASL8zcB in 2024-05-08 so not in the training dataset.

[Jan Kosinski @jankosinski]

And another one, maybe without the training bias. Should bind specifically promoter region ATTTTAGTCGCGCCTAAAAT and it does again! Left is crystal structure, right is the AlphaFold3 model. Promoter is in red.

[Luisa Maia @LuisaBMaia]

📢 ONLY ONE WEEK LEFT
to submit your abstract to
2024 #Inorganic & Bioinorganic #Chemistry Conference, #2024IBiCC

📅: May 16 - 18, 2024
🌏: Lisboa 🇵🇹
https://t.co/08GlPnmb7G

[Cristiano Mota @cmota_15]

Check out our newest preprint reveiling a Mn sensor from #Deinococcus, bound to the promoter region of MntH. Mn ions accumulation is crucial for ROS scavenging & proteome protection in this highly resistant bacterium. @esrfsynchrotron @UCIBIO_Research
https://t.co/3nwmLHeuft

[Luisa Maia @LuisaBMaia]

📢 2024 #Inorganic & Bioinorganic #Chemistry Conference

#2024IBiCC
📅: May 16 - 18, 2024
🌏: Lisboa, Portugal 🇵🇹
⚠️ Key dates:
abstracts submission: April 1, 2024
early bird registration: April 15, 2024
More info: https://t.co/nN8lTcuPNp

[UCIBIO @UCIBIO_Research]

Congratulations to @UCIBIO_Research researchers @XTALUCIBIOFCTN1 for the new study published @nchembio, in collaboration with @itqbnova @BIP6_Marseille revealing how a formate dehydrogenase can withstand oxygen exposure.
More: https://t.co/AOwYpAVn57
@i4HBio @FCTNOVA @NOVAunl

[Cristiano Mota @cmota_15]

Our first preprint! Very proud of the excellent work by
Vilela-Alves and coworkers, demonstrating at the atomic level how a W/SeCys-Fdh gets inactivated by oxygen. @FCTNOVA @UCIBIO_Research @i4HBio @XTALUCIBIOFCTN1 @NMRFCTNOVA1 @itqbnova @esrfsynchrotron https://t.co/zX05iHhy0g.

[bioRxiv @biorxivpreprint]

Substrate-dependent oxidative inactivation of a W-dependent formate dehydrogenase involving selenocysteine displacement. https://t.co/E0bvKomZNr #bioRxiv

[Ana Rita Oliveira @AnaOlivetree]

Check out our work unraveling the molecular basis for the unusual oxygen tolerance of W-Sec-FDH: a redox switch based on an allosteric disulfide bond regulates both high CO2 reductase activity and oxygen tolerance. https://t.co/yToIOU2rj7 #enzymatic #CO2reduction +

[ITQB NOVA @itqbnova]

Congrats to Delfim Manuel Araújo Ferreira for his PhD in Molecular #Biosciences! 🎓 👏

His #research, "Unraveling the metabolic pathway of dissimilatory sulfate reduction", was supervised by @InsCardosoPere1 and co-supervised by Sofia Venceslau.

#TeamNOVA #MolBioS
@NOVAunl

[Matthew Bowler @moncourvoisier]

Kicking off our fantastic @esrfsynchrotron @EMBLGrenoble @ESRF_Streamline workshop on ambient temperature crystallography with DoR Michael Krisch

[Inês Cardoso Pereira @InsCardosoPere1]

So happy to see these results finally published in @nchembio! Very proud of the great work by @AnaOlivetree @cmota_15 and coworkers revealing how an FDH can withstand oxygen exposure.👏🍾@itqbnova @FCTNOVA @BIP6_Marseille @LS4FUTURE @i4HBio
#CO2
https://t.co/aerp266WCk

[UCIBIO @UCIBIO_Research]

Congratulations to Cristiano Mota @XTALUCIBIOFCTN1 who coordinates one of the approved projects in the Call for Cooperation in Science between Portugal & Germany FCT-DAAD for 2023/2024, with a German team @unihh and T-REXX beamline at PETRAIII
More https://t.co/qHgi7pMNYF
#UCIBIO

[Maria J. Romão @mjrmadeira]

Tracking W-Formate Dehydrogenase Structural Changes During Catalysis and Enzyme Reoxidation https://t.co/ZNqmLajlD5 #mdpiijms via @IJMS_MDPI

[Cristiano Mota @cmota_15]

@Xuelei_Lai Congrats Xuelei!! I wish you the best!

[UCIBIO @UCIBIO_Research]

New study developed by @XTALUCIBIOFCTN1 @NMRFCTNOVA1 @UCIBIO_Research @FCTNOVA unveiled the mechanisms of 3 inhibitors to an important human drug metabolizing enzyme by combining X-ray crystallography, NMR spectroscopy and kinetic assays.
@ACSBioMed
More: https://t.co/AqaGOHN1DK

[Maria J. Romão @mjrmadeira]

Interrogating the Inhibition Mechanisms of Human Aldehyde Oxidase by X-ray Crystallography and NMR Spectroscopy: The Raloxifene Case https://t.co/jRmxtOCSH0