Colin Logie

Author of Spatial patterns of CTCF sites define the anatomy of TADs and their boundaries in Genome Biology Read here:

[Colin Logie @colinlog]

7 resources and 100ds of papers were curated to catalogue 1,457 human genes that fit the Molecular Function ‘sequence-specific DNA binding transcription factor’.

[Functional Gene Annotation @UCLgene]

A GO catalogue of human DNA-binding transcription factors https://t.co/DALBrgGSln @biocurator @costgreekc @UCL_ICS @UCLIoN @news4go @uniprot @ARUKscientist @DementiasUK @dem_researcher #transcription @AllAboutTFs

[Warren Terra @warren__terra]

@ValWood5 @bparsia Absolutely - to both sides. I have used GO enrichment and have encountered interesting, meaningful GO enrichment, and also I flinch whenever it arises in a talk or paper.

[Colin Logie @colinlog]

@GenomeBiology @stefanoceri Notice that the Tweeter of Genome Biology
@GenomeBiology got it wrong? >< are not TAD boundaries. <>> and <<> are! The convergent sites ><< and >>< mark right-biased (-> ->) to left-biased (<-<-) interaction transitions! Simple is not easy, Elegant is not straightforward.

[Colin Logie @colinlog]

Our paper on the CTCF site anatomy of Topologically Associating chromosome Domains (TADs) is out in the on-line journal Genome Biology https://t.co/Ok8irDN178. #CTCF #3Dgenome

[Colin Logie @colinlog]

#CTCF# #3Dgenome#

[Genome Biology @GenomeBiology]

Nanni, @stefanoceri and @colinlog analyze clusters of CTCF sites, according to their orientation. Over the 5-100 kb range, divergent sites (eg <<>>) are enriched and convergent sites (>><<) are depleted. Convergent sites mark boundaries of TADs https://t.co/bm3l6Qaa2Q

[Genome Biology @GenomeBiology]

Nanni, @stefanoceri and @colinlog analyze clusters of CTCF sites, according to their orientation. Over the 5-100 kb range, divergent sites (eg <<>>) are enriched and convergent sites (>><<) are depleted. Convergent sites mark boundaries of TADs https://t.co/bm3l6Qaa2Q