Alex Connery, PharmD

Neurocritical Care Pharmacist @ Hackensack University Medical Center

[Alex Connery, PharmD @ConneryPharmacy]

Will this study impact your practice regarding afib prophylaxis in patients after intracerebral hemorrhage?

[Alex Connery, PharmD @ConneryPharmacy]

Next Up Nicole Castoro, PharmD, PGY2 Critical Care Resident, NewYork-Presbyterian Hospital presenting Direct oral anticoagulants versus no anticoagulation for the prevention of stroke in survivors of intracerebral haemorrhage with atrial fibrillation (PRESTIGE-AF)

#NCSPharmJC

[Alex Connery, PharmD @ConneryPharmacy]

Summary: In survivors of intracerebral hemorrhage with atrial fibrillation, DOACs substantially reduced the risk of ischemic stroke compared to no anticoagulation, but this benefit was offset by a significantly increased risk of recurrent ICH

Thanks Dr. Castoro!

[Alex Connery, PharmD @ConneryPharmacy]

The DOAC group had a significantly lower risk of ischemic stroke than the non-anticoagulated group (unadjusted HR 0.05 (0.01-0.36)) but also had a significantly higher risk of recurrent ICH (unadjusted HR 10.89 (1.95-60.72))

#NCSPharmJC

[Alex Connery, PharmD @ConneryPharmacy]

The DOAC group had a significantly lower risk of ischemic stroke than the non-anticoagulated group (unadjusted HR 0.05 (0.01-0.36)) but also had a significantly higher risk of recurrent ICH (unadjusted HR 10.89 (1.95-60.72))

#NCSPharmD

[Alex Connery, PharmD @ConneryPharmacy]

Thanks to Dr. Beyer for Presenting!

What are some operational and safety considerations for adopting modified-release nicardipine implants?

[Alex Connery, PharmD @ConneryPharmacy]

First Up Alyssa Beyer, PharmD, PGY2 Critical Care Resident, Tufts Medical Center presenting on Localized Nicardipine Release Implants for Prevention of Vasospasm After Aneurysmal Subarachnoid Hemorrhage. A Randomized Clinical Trial

#NCSPharmJC #NCSPharm

[Alex Connery, PharmD @ConneryPharmacy]

Summary: Localized modified-release nicardipine implants placed into basal cisterns at clipping  for aneurysmal subarachnoid hemorrhage safely reduced moderate-severe angiographic vasospasm versus standard of care and signals toward reduced delayed cerebral ischemia/resource use

[Alex Connery, PharmD @ConneryPharmacy]

Strengths included similar use of established treatments (nimodipine) in each arm while  this study may have been limited by a small sample size and limited population

#NCSPharmJC