CPPopt

[CPPopt @CPP_opt]

We did it! First CPPopt feasibility and safety trial!
Results are here doi: 10.1089/neu.2021.0197

Is precision medicine in #TBI in #CriticalCare feasible? CPPopt as an individualised dynamic CPP target for protecting the brain.
Thanks #COGiTATE team for this work!

[Marcel aries @aries_marcel]

The Autoregulation-Guided Cerebral Perfusion Pressure after Traumatic Brain Injury (COGITATE) results have been published!! @AriErcole @DrSmielewski @Menon_Cambridge @TasJeanette @iccvanderhorst @joseph_aotearoa @pja_hutch @erta_beqiri @GMeyfroidt
Link: https://t.co/HQZBFg80pq

[Royal College of Anaesthetists @RCoANews]

The President’s Commendation for a sustained contribution to the College was presented to Dr Rana Hafiz Ur Rehman.

Dr Ari Ercole gave the Macintosh Professor Lecture. Seen here with President Dr Claire Shannon and Prof Iain Moppett.

Read more: https://t.co/utItQoHmV4

[NCCU Cambridge UK @NCCUCambridge]

Wonderful news for a remarkable colleague, friend, and doctor.

[AriErcole @AriErcole]

Traumatic brain injury #TBI phenotypes from @CenterTBI #ICU data by probabilistic time-series clustering

𝗧𝗲𝗺𝗽𝗼𝗿𝗮𝗹 𝘃𝗮𝗿𝗶𝗮𝘁𝗶𝗼𝗻 of brain injury 𝗯𝗶����𝗺𝗮𝗿𝗸𝗲𝗿𝘀 = missing link in describing the 𝗰𝗹𝗶𝗻𝗶𝗰𝗮𝗹 course

https://t.co/y6wzPwqRzA
@TheLancetNeuro

[AriErcole @AriErcole]

ICP is strongly confounded by therapeutic intensity level (TIL) after #TBI. Measuring TIL crucial to understand severity

Various TIL scores validated in @CenterTBI https://t.co/qJTnlb23lz

@TBI_data_guy nails TIL representing 'refractory' ICP:
TILᵐᵉᵈ≥7.5

[AriErcole @AriErcole]

A solution to the age-old problem of where to zero the transducer in neurocritical care...

https://t.co/EPP6n8CWGl
https://t.co/AiaD2KeHOv

[AriErcole @AriErcole]

Does what happens in #ICU stay in ICU after #TBI?

Well done @TBI_data_guy for time-series #machinelearning model ingesting 𝑎𝑙𝑙
@CenterTBI data with minimal pre-processing looking at contribution of clinical course events to outcome in
@npjDigitalMed
https://t.co/Q2brWt2F9n

[Intensive Care Medicine @yourICM]

Precision medicine to improve outcome after traumatic brain injury: data-driven approaches to identify pathophysiological or pathobiological mechanisms to individualize treatments
🧠suggestions for #TBI phenotypes
🧠methodological considerations
#FOAMcc
🔓 https://t.co/bW8R9zKLcI

[AriErcole @AriErcole]

Machine learning and novel algorithmic techniques show great potential, but need to be applied and interpreted correctly

Right question+right data+right method

https://t.co/FSYpf1iPCa

@CC4AIM

[AriErcole @AriErcole]

Unsupervised clustering in @CenterTBI finds 6 stable endotypes of #TBI in the #ICU

⚠️Systemic metabolic stress important differentiating patients as well as traditional GCS classification

https://t.co/6vujCQAQTX
https://t.co/I1xv1JRpEW

[AriErcole @AriErcole]

#TraumaticBrainInjury research often dichotomises outcomes. Here's how to handle ordinal outcomes from @shubhayu_neuro including a #machinelearning approach using 𝙖𝙡𝙡 the @CenterTBI features for best prediction

https://t.co/xzDXjwnRt2

[AriErcole @AriErcole]

Some 𝘷𝘦𝘳𝘺 important things to know about the challenges of large-scale observational data collection in #TBI from @CenterTBI

https://t.co/8uL4VxTJuI

[NIHR GHRG on Acquired Brain & Spine Injury (ABSI) @global_neuro]

Primary analysis of @global_neuro Global Neurotrauma Outcomes Study #GNOS published tonight @TheLancetNeuro.

https://t.co/azr4hvKO7E

Phenomenal collaboration of clinicians from 57 countries 🌍.

#WFNS2022 #globalneurosurgery #globalneurotrauma #TBI

[Marcel aries @aries_marcel]

Yes, and Cogitate study is one of the most read papers in 2021!!

[CPPopt @CPP_opt]

COGiTATE results presented at the #BNRG2021 by our team member @erta_beqiri

Great meeting, fantastic talks! Inspiration for the future

@BrainPhysics @icm_plus

[CPPopt @CPP_opt]

Reduced physiological cross-talk associated with mortality after #TBI

Well done Giovanna, @BrainPhysics @DrSmielewski @erta_beqiri @pl219_Cambridge @AriErcole and all @CenterTBI collaborators

https://t.co/2ubrAAuEaP

[AriErcole @AriErcole]

First ever prospective randomised controlled trial to assess feasibility and safety of a 'digital biomarker' for individualised care of #TBI patients on #ICU

➡️ both feasible and safe

#COGITATE
https://t.co/N0Bi2g05g5

[CPPopt @CPP_opt]

https://t.co/YjByp8bJwZ

[CPPopt @CPP_opt]

We did it! First CPPopt feasibility and safety trial!
Results are here doi: 10.1089/neu.2021.0197

Is precision medicine in #TBI in #CriticalCare feasible? CPPopt as an individualised dynamic CPP target for protecting the brain.
Thanks #COGiTATE team for this work!

[Marcel aries @aries_marcel]

The Autoregulation-Guided Cerebral Perfusion Pressure after Traumatic Brain Injury (COGITATE) results have been published!! @AriErcole @DrSmielewski @Menon_Cambridge @TasJeanette @iccvanderhorst @joseph_aotearoa @pja_hutch @erta_beqiri @GMeyfroidt
Link: https://t.co/HQZBFg80pq

[CPPopt @CPP_opt]

@BrainPhysics

[AriErcole @AriErcole]

Glasgow Coma Score & pupil reactivity=crucial #TBI outcome determinants but timepoints frequently missing in real-world data

Evaluation of methods for effective imputation by @CenterTBI...
... the answer depends on the question!

https://t.co/UU0vLA1Dbm