Christopher P. Jones

RNA structure geek seeking small molecules to inhibit bacteria and viruses, more mob than man, views = my own

[Christopher P. Jones @cpricejones]

Where are the snoRNAs of yesteryear? I reflect on past and future #RNA research, the genomic tag hypothesis, and nostalgia for "solved" #science questions. https://t.co/oelC73qHKt

[Christopher P. Jones @cpricejones]

Any ideas what this object is? Virus? Membranous extension? #cryoEM

[Christopher P. Jones @cpricejones]

@tiwarylab Are there initial conditions or growth rate conditions that give inclusions? That would be cool

[Christopher P. Jones @cpricejones]

@Caroline_Bartma I love them if they’re well written. Sometimes if I am trying to flare / throw darts wildly, I’ll browse by only reading discussions. The best ones IMO lack summary, draw smartly from disparate sources, and speculate semi-wildly.

[Christopher P. Jones @cpricejones]

@Kim_Hanseong Definitely looks better in one direction than the other

[Christopher P. Jones @cpricejones]

Dual wielding Krioses 😛 #cryoem #rna

[Christopher P. Jones @cpricejones]

@nencki Mice are ~50% brain tissue, which is why they are great at running mazes and pressing sturbly

[Christopher P. Jones @cpricejones]

@ShechnerLab @JMTali Phosphorothioates hate this one simple trick

[Christopher P. Jones @cpricejones]

@GntlmnScientist Just mediocre resolution

[Christopher P. Jones @cpricejones]

@Rattapoom_K God Emperor of Dune, (Book 4 of the OG series)

[Christopher P. Jones @cpricejones]

@ProfMMurray @StrictScrutiny_ Strict Scrutiny coming back to DC is like The Beatles returning home to England. I guess in this analogy, SCOTUS is Her Majesty, dead and replaced by an old white guy.

[Christopher P. Jones @cpricejones]

Anyone seen morels yet in the DC area? Very nice weather #morels

[Christopher P. Jones @cpricejones]

@lesliedayly In a jiff, it also doubles up as a super soaker in a lab battle

[Christopher P. Jones @cpricejones]

Has anyone gotten the GMM (Gaussian mixture model) conversion/refinement to work? #cryoem

[Christopher P. Jones @cpricejones]

@GntlmnScientist It was probably just salt (or at least that’s what I tell myself)

[Christopher P. Jones @cpricejones]

@zakir_tnimov

[Christopher P. Jones @cpricejones]

@klausenhauser @jonaszpatkowski For that density threshold, there is a Glu that looks pretty much absent. I mean the alternative is letting the B factors blow up when you refine. My guess is that side chain will be like 200-300 compared to the lower main chain nearby.

[Christopher P. Jones @cpricejones]

@MariuszCzC Nice ring though … I just lose resolution when I tilt 😬

[Nature Portfolio @NaturePortfolio]

A Review in @NatRevChem highlights the strategies and challenges for targeting RNA with small molecules in medicinal chemistry, emphasizing their potential as drugs and tools for understanding complex biological processes. 🔒 https://t.co/9FkeVVbYIA

[Christopher P. Jones @cpricejones]

😬 “purified”