Piperine from black pepper is Anti-testosterone & progesterone - toxic and serotonergic
Piperine is added to some supplements, and black pepper is common in food cupboards / with dinners. Apparently can be 3% piperine - 5% piperine in black pepper but varies alot
https://t.co/XmpBD8AIy7
Feeding ~100mg-150mg piperine human equivalent to rats is toxic to testicles. lowers testosterone (+ progesterone) & leydig cell function

Our study result suggests that piperine disrupted the functional integrity of the testis by altering the germ cell markers, antioxidant
status, and testicular hormones. These biochemical study results were further reinforced by histopathological observation of hypospermatogenesis on piperine treatment.
However, the toxic effects of piperine were reversed affer the drug‑free withdrawal period of 60 days.
Omega-3 Decreases D1 And D2 Receptors Expression In The Prefrontal Cortex
Amphetamine (AMPH) abuse is a serious public health problem due to the high addictive potential of this drug, whose use is related to severe brain neurotoxicity and memory impairments. So far, therapies for psychostimulant addiction have had limited efficacy. Omega-3 polyunsaturated fatty acids (n-3 PUFA) have shown beneficial influences on the prevention and treatment of several diseases that affect the central nervous system. Here, we assessed the influence of fish oil (FO), which is rich in n-3 PUFA, on withdrawal and relapse symptoms following re-exposure to AMPH. Male Wistar rats received d,l-AMPH or vehicle in the conditioned place preference (CPP) paradigm for 14 days. Then, half of each experimental group was treated with FO (3 g/kg, p.o.) for 14 days. Subsequently, animals were re-exposed to AMPH-CPP for three additional days, in order to assess relapse behavior. Our findings have evidenced that FO prevented relapse induced by AMPH reconditioning. While FO prevented AMPH-induced oxidative damages in the prefrontal cortex, molecular assays allowed us to observe that it was also able to modulate dopaminergic cascade markers (DAT, TH, VMAT-2, D1R and D2R) in the same brain area, thus preventing AMPHinduced molecular changes. To the most of our knowledge, this is the first study to show a natural alternative tool which is able to prevent psychostimulant relapse following drug withdrawal. This non-invasive and healthy nutraceutical may be considered as an adjuvant treatment in detoxification clinics.
https://t.co/da6j1AVwnh
7 Foods men should eat for stronger and harder erections, improved strength and stamina, and support overall men’s sexual health.
Here are seven key foods to help manage erectile dysfunction:
1Leafy Greens (Spinach/Lettuce): High in nitrates, which improve blood flow by converting to nitric oxide, helping blood vessels relax and widen.
2. Berries and Citrus Fruits(Blueberries/Oranges): Rich in flavonoids, which are antioxidants that boost vascular health and improve erectile function.
3Fatty Fish (Salmon/Mackerel): Rich in Omega-3 fatty acids, which increase nitric oxide production and enhance blood flow.
4Nuts and Seeds (Walnuts/Almonds): High in zinc, amino acids (L-arginine), and Omega-3s, which improve blood vessel health.
5Avocados: A good source of zinc and Vitamin E, which are crucial for hormone regulation and testosterone production.
6Dark Chocolate: Contains flavonoids that improve heart health and circulation.
7Watermelon: Contains L-citrulline, a compound that can convert to L-arginine and enhance blood flow.
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AUBRAI staking is live!
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