CS

[CS @csandbach]

@AdamSchefter @WerderEdNFL

[Massimo @Rainmaker1973]

A new shot literally regrows knee cartilage.

Researchers at Stanford Medicine have identified a novel strategy to regenerate articular cartilage in knees and potentially prevent or treat osteoarthritis (OA).

The method targets 15-hydroxyprostaglandin dehydrogenase (15-PGDH), an age-related enzyme—or "gerozyme"—that accumulates in aging tissues and drives degeneration.

In aged mice, small-molecule inhibitors of 15-PGDH, delivered systemically or via intra-articular injection, promoted cartilage thickening and regeneration of functional hyaline articular cartilage.

This occurred without recruiting stem or progenitor cells; instead, existing chondrocytes underwent transcriptional reprogramming to a youthful state, with reduced populations of inflammatory and hypertrophic/degradative cells and expanded matrix-producing articular chondrocytes.

The inhibitors also reversed natural age-related cartilage thinning, improved joint function, and—when administered after simulated ACL injuries—strongly mitigated post-traumatic OA progression and associated pain.

Human OA cartilage explants from total knee replacements responded similarly in vitro, showing decreased degradation markers and evidence of new articular cartilage formation.

Given that an oral 15-PGDH inhibitor has already completed Phase 1 safety trials for age-related muscle atrophy, the findings open a path toward disease-modifying, regenerative therapies that could delay or obviate the need for joint replacement surgery.

[Agarwal, P., Su, S., Ancel, S., et al. (2025). Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration. Science. DOI: 10.1126/science.adx6649]

[Clemson Men's Golf @ClemsonMGolf]

JACOB BRIDGEMAN! CHAMPION!!

[Words of Wise | Mindset Coach @Wordofwise_]

Get back to work.

[Chase Daniel @ChaseDaniel]

My thoughts on the Broncos & Sean Payton without Bo Nix moving forward.

Jarrett Stidham is going to absolutely sling it…speaking from experience one backup to another.

[NFL Hate Memes @NFLHateMemes]

BREAKING NEWS: NFL is considering removing pass interference from the rule book after Josh Allen loses another playoff game

[CS @csandbach]

@barstoolsports INT.

[CS @csandbach]

@Rockies

[CS @csandbach]

Oh, and then there is this too. Probably because it’s such a shit hole that’s why Disney picked it. Seriously dude @mikesparkman what sort of backwoods Alabama crank were you smoking when you made this comment? Honestly, other than trying to just be a troll I’m very curious what prompted your comment.

[CS @csandbach]

@mikesparkman @NoEscalators Yep sounds just awful.

[CS @csandbach]

@blakestbanter No, he is right.

[CS @csandbach]

@MLB

[CS @csandbach]

@DMacSportsCO @AltitudeSR

[CS @csandbach]

@DNVRSaez @BDSpenc

[CS @csandbach]

@csualum1994 @BarstoolCSU Continued undisciplined play and personal fouls that has been a constant staple of the Norvell and now the post Norvell era. This program is in full rebuild mode and “shit” like this doesn’t need to come long. Create the precedent that “this shit” has no place in the future.

[CS @csandbach]

@realTWB52 @bunchapansies @Ballgame_KTIK There is one week left, one less on the roster will not effect anything.

[CS @csandbach]

@realTWB52 @bunchapansies @Ballgame_KTIK You’re right he doesn’t deserve a second chance, just not in Fort Collins.

[CS @csandbach]

@treywallace Dismiss him immediately. This is clown shit and a program in full rebuild shouldn’t keep this crap around.

[CS @csandbach]

@ColoradoanSpts Appears? Kennedy’s head appears to blow up in the Zapruder film too.