CTCPR Trials & CIRL

Center for Translational Cardiology and Pragmatic Randomized Trials / Cardiovascular Non-Invasive Imaging Research Laboratory. Led by Prof @TorBiering

[CTCPR Trials & CIRL @CTCPR_]

🫀New @CTCPR_ study in The International Journal of Cardiovascular Imaging

Mathilde Zeuthen Pedersen and colleagues show that cardiac diastolic dysfunction is strongly linked to kidney failure risk in CKD.

Study design
731 CKD patients followed for 3.8 years with comprehensive echocardiography.

Key findings
• Severe LV diastolic dysfunction → ~3x higher risk of ESKD
• E/e’ >14 → >3x higher risk
• Consistent signal across diastolic markers

💡Cardiac function may help identify CKD patients at highest risk of progression.

📄See full study: https://t.co/eaOF6Fyol4

@TorBiering
@CopCard
@RigsHeart
@HGHHjerte
@Stenodiabetes
@niklasdj1
@matslassen
@KristofferSkaar
@fwemmer1

[CTCPR Trials & CIRL @CTCPR_]

💉 What if we looked beyond statistical significance?

A new Bayesian re-analysis of the DANFLU-1 trial by Daniel Modin and colleagues from @CTCPR_, published in Human Vaccines & Immunotherapeutics, included 12,477 adults aged 65–79 years.

Key insights:
• >95% probability that high-dose vaccination reduces all-cause mortality
• >95% probability of reducing influenza/pneumonia hospitalizations
• Findings were consistent across non-informative, evidence-based, and skeptical priors

The results strengthen the evidence supporting high-dose influenza vaccination in older adults.

📄 See full study: https://t.co/RkbGcFJYQi

@TorBiering
@CopCard
@RigsHeart
@HGHHjerte
@Stenodiabetes
@niklasdj1
@RebeccaCHarris
@AM_reimer

[CTCPR Trials & CIRL @CTCPR_]

🫀Who benefits from subclinical AF screening?

A LOOP trial substudy led by @fwemmer1 and colleagues from @CTCPR_, published in the Journal of the @American_Heart, tested whether echocardiographic markers modify the effect of ILR-based SCAF screening on stroke.

Study design
1,422 participants were randomized to ILR screening vs usual care (5.5-year follow-up), with echocardiography in a subset (24%).

Key insights
• No overall stroke reduction with ILR screening (3.9% vs 3.8%)
• Conventional echo measures showed no effect modification
• Only left atrial contraction strain identified benefit (HR 0.38 in low strain)

💡Atrial function—not standard echo—may help identify patients who benefit from screening.

Full study link: https://t.co/j8zkPwqqg4

@TorBiering
@CopCard
@RigsHeart
@HGHHjerte
@Stenodiabetes
@PeterGodsk

[Manan Pareek, MD, MSc, PhD, FACC, FAHA, FESC @MananPareekMD]

Extremely proud of friend, colleague, and boss, @TorBiering, for receiving the 2026 Danish Society of Cardiology & Danish Heart Foundation @cardio_dk Research Prize! This award is in recognition of his massively innovative, outstanding research efforts - Tor, you’re the man!

[Ankeet S. Bhatt, MD, MBA, ScM @ankeetbhatt]

Congrats @TorBiering. So well deserved. Brilliant scientist, researcher, colleague and friend. Thanks for inspiring us! @CTCPR_

[CTCPR Trials & CIRL @CTCPR_]

🫀Can cardiac myosin inhibition improve outcomes in non-obstructive HCM?

A new publication by Kaveh Hosseini and colleagues from @CTCPR_, published in Heart Failure Review, highlights findings from the phase 3 ODYSSEY-HCM trial evaluating mavacamten in symptomatic nHCM.

Key findings:
• Clear biomarker and imaging effects
• No significant improvement in functional capacity or quality of life
• Reversible reductions in EF required dose interruption in some patients

💡Target engagement alone may not be enough to achieve meaningful clinical benefit in nHCM.

Study link: https://t.co/v4kSF0jPw2

@TorBiering
@CopCard
@RigsHeart
@HGHHjerte
@Stenodiabetes

[CTCPR Trials & CIRL @CTCPR_]

🫀 What is the long-term cardiovascular impact of RSV infection?

New nationwide Danish data study from Anders Hviid and colleagues from @CTCPR_, published in @JAMANetworkOpen, followed adults ≥45 years with laboratory-confirmed RSV for 1 year using Danish health registries.

Key findings:
- RSV was associated with a significant excess risk of cardiovascular events
- Highest risks were seen in hospitalized patients, older adults, and those with CVD or diabetes
- Cardiovascular risk after RSV was comparable to influenza

💡RSV may be an important contributor to long-term cardiovascular morbidity — highlighting the importance of prevention and vaccination.

Full study link: https://t.co/X6nNpS9Y2u

@TorBiering
@CopCard
@RigsHeart
@HGHHjerte
@Stenodiabetes

[CTCPR Trials & CIRL @CTCPR_]

🫁 What do B-lines on lung ultrasound mean in hospitalized COVID-19 patients?

A new study by Øyvind Johannessen, @pmyhre and colleagues from @CTCPR_, published in @Frontiers in Cardiovascular Medicine, examined 270 non-ICU COVID-19 patients using 8-zone lung ultrasound a median of 4 days after admission.

Key insights 👇
✔️ B-lines were almost universal (97%)

✔️ Associated with inflammation and severity
• Higher CRP
• Higher Early Warning Score
• Higher pulmonary pressure (TR gradient)

❌Not linked to left heart function or NT-proBNP

❌Not associated with 30-day mortality

💡In COVID-19, B-lines reflect inflammation and pulmonary stress—not left-sided heart failure.

Full study link: https://t.co/5UEwARKZLz

@TorBiering
@CopCard
@RigsHeart
@HGHHjerte
@Stenodiabetes
@fdavidovski_MD
@Espersen_C
@niklasdj1
@AnneBjergn
@JakobOeystein
@MortenSengelov

[CTCPR Trials & CIRL @CTCPR_]

🫀How much of the cardiac risk in psoriasis patients with MASLD is driven by the liver disease itself — and how much by underlying cardiometabolic risk factors?

New study by @dons_maria and colleagues from @CTCPR_, published in @JInternMed, examined cardiac structure/function and MASLD in 255 adults with psoriasis.

Key findings 👇
✔️MASLD was linked to worse cardiac function and adverse cardiometabolic profiles
✔️After adjustment, BMI and diabetes were independently associated with myocardial dysfunction

💡Highlights the importance of cardiometabolic risk factor control in psoriasis patients with MASLD.

Full study: https://t.co/Eo92EMJA7T

@TorBiering
@CopCard
@RigsHeart
@HGHHjerte
@Stenodiabetes
@fdavidovski_MD
@KristofferSkaar
@AM_reimer
@MortenSengelov

[CTCPR Trials & CIRL @CTCPR_]

🫀Can advanced strain imaging improve risk stratification after CABG?

New study by @fdavidovski_MD and colleagues from @CTCPR_, published in the International Journal of Cardiovascular Imaging, examined layer-specific GLS in 641 CABG patients using speckle-tracking echocardiography.

Key findings 👇
✔️Reduced GLS across all myocardial layers was linked to higher mortality
✔️Epicardial GLS remained independently prognostic even after EuroSCORE II adjustment
✔️Layer-specific GLS was associated with HF/CV death outcomes

💡Advanced echocardiographic strain imaging may add important prognostic value after cardiac surgery.

Study link: https://t.co/QTCeUIAhdx

@TorBiering
@CopCard
@RigsHeart
@HGHHjerte
@Stenodiabetes
@matslassen
@KristofferSkaar
@Espersen_C
@MortenSengelov
@fwemmer1

[CTCPR Trials & CIRL @CTCPR_]

🎓Congratulations to our newest PhD, @matslassen!

On Friday (15/05/26), Mats successfully defended his PhD thesis titled:
"Effect of Respiratory Syncytial Virus Vaccination on Cardiorespiratory Hospitalizations - From observational data to randomized evidence: Insights from a registry-based cohort study and a pragmatic randomized clinical trial”

Mats's PhD focused on RSV, cardiovascular disease, and pragmatic clinical trials, with a particular focus on the DAN-RSV trial - a large-scale pragmatic randomized trial embedded within the Danish nationwide digital health infrastructure.

An impressive milestone driven by collaboration and dedication. Congratulations from all of us at @CTCPR_ 👏

@TorBiering
@UCPH_health
@CopCard
@RigsHeart
@HGHHjerte
@Stenodiabetes

[CTCPR Trials & CIRL @CTCPR_]

🚨Clinical Assistant wanted at @CTCPR_ , Gentofte Hospital

1-year position (PhD option)

Work includes:
• Clinical trials & RCTs
• Patient inclusion & clinical work
• Data, analysis & manuscripts
• Conferences & research

MD with interest in cardiology & research.

📩Apply here: https://t.co/bAnKALR2LR

@TorBiering
@Stenodiabetes
@CopCard
@Rigshospitalet
@HGHHjerte
@HerlevGentofte

[CTCPR Trials & CIRL @CTCPR_]

🚨 We’re hiring: Postdoc / Senior Researcher in Cardiovascular Research

MD with PhD (or PhD track)? Strong in CV research, trials & epidemiology?

Join @CTCPR_ , Gentofte Hospital—an internationally recognized center working with clinical studies, registry research & large-scale RCTs.

We’re looking for experience in:
• Cardiovascular medicine & clinical research
• Clinical trials (RCTs/pragmatic designs)
• Stats & study design (R / Stata / SAS)
• Registry/epidemiology research
• CV imaging (echo = plus)
• Scientific writing & publications

Work closely with clinicians, statisticians, PhD students & international collaborators in a high-impact, ambitious environment.

📩Full details & application:
https://t.co/ymSiLQR9DK

@TorBiering
@Stenodiabetes
@CopCard
@Rigshospitalet
@HGHHjerte
@HerlevGentofte

[CTCPR Trials & CIRL @CTCPR_]

🚨We’re hiring: Data Manager / Biostatistician at @CTCPR_

Join our cardiovascular research team at Gentofte Hospital working with:
• Danish national health registries
• Large-scale randomized clinical trials
• Statistical analyses & data management
• Real-world cardiovascular research

Open positions:
🔹1-year Data Manager/Biostatistician
🔹3-year Biostatistician

Looking for candidates with experience or interest in:
📊Statistics / epidemiology
💻SAS, R, Python, Stata etc.
📑Registry & clinical research

Full job posting below 👇
https://t.co/eyRmpiKf0i

@TorBiering
@Stenodiabetes
@CopCard
@Rigshospitalet
@HGHHjerte
@HerlevGentofte

[CTCPR Trials & CIRL @CTCPR_]

🫀Are patients with atrial fibrillation better protected with high-dose influenza vaccines?

New study by @Espersen_C & @CTCPR_ (@ACCinTouch) using DANFLU-2:
- n=332,438 adults ≥65 years
- 34,085 (10.3%) with AF
- Randomized to high-dose vs standard-dose influenza vaccine across 3 seasons

🔑Key findings:
AF patients had markedly higher risks of influenza-related & cardiovascular hospitalizations
High-dose vaccine ↓ hospitalizations for:
- Cardiorespiratory disease
- Influenza (incl. lab-confirmed)
- Cardiovascular disease
Effects consistent regardless of AF status
Greater absolute benefit in AF (NNV ~243 vs ~933 in non-AF)

Worth noting:
The trial was not powered for the AF subgroup analyses, meaning these findings should be considered hypothesis-generating.

Implication:
In high-risk populations like AF, vaccine choice—not just vaccination—may matter 🫀

📄 Study link: https://t.co/9XgDYYmT1S

@TorBiering
@CopCard
@RigsHeart
@HGHHjerte
@Stenodiabetes
@RebeccaCHarris
@matslassen
@KristofferSkaar
@niklasdj1
@AM_reimer
@dons_maria
@KBernholm
@fdavidovski_MD
@LisaSteenDuus
@camillaiottosen
@AnneBjergn
@drJBorchsenius
@katjabartholdy
@AdamLanghoff
@MortenSengelov

[CTCPR Trials & CIRL @CTCPR_]

🫀Are CKD patients underprotected during flu season?

New study by @katjabartholdy & colleagues from @CTCPR_ using DANFLU-2 (n=332,438; 14% CKD) has been published in the journal of @ACCinTouch

Key findings:
• HD vaccine ↓ flu/pneumonia hosp. by 16.9% in CKD (vs 0.6%)
• ↓ influenza hosp. by 68.6% in CKD
• Cardiorespiratory benefits consistent across groups

Important context:
The trial was not powered for the CKD subgroup analyses, so these findings should be considered hypothesis-generating.

Implication:
Vaccine choice may matter most in high-risk patients🫀

Full study: https://t.co/dH4wkBfYvw

@TorBiering
@CopCard
@RigsHeart
@HGHHjerte
@Stenodiabetes
@RebeccaCHarris
@matslassen
@KristofferSkaar
@niklasdj1
@AM_reimer
@dons_maria
@KBernholm
@fdavidovski_MD
@LisaSteenDuus
@camillaiottosen
@AnneBjergn
@drJBorchsenius
@Espersen_C
@AdamLanghoff
@MortenSengelov

[CTCPR Trials & CIRL @CTCPR_]

🫀Key insight: Inflammation may drive early cardiac dysfunction in psoriasis

New study by @dons_maria & @CTCPR_ (Int J Cardiol – Heart & Vasculature), n=972

Highlights:
↑ hsCRP → ↓ GLS & LVEF
Highest hsCRP tertile → more systolic & diastolic dysfunction
hsCRP >2 mg/L → +45% odds of myocardial dysfunction

Implication:
hsCRP may help identify early CV risk in psoriasis

📄 Study link: https://t.co/DZ4mqXWdPa

@TorBiering
@CopCard
@RigsHeart
@HGHHjerte
@Stenodiabetes
@niklasdj1
@MortenSengelov
@fdavidovski_MD
@matslassen
@KristofferSkaar
@drJBorchsenius

[Tor Biering-Sørensen, MD, MSc, MPH, PhD @TorBiering]

Today we at @CTCPR_ started recruitment for our most recent GIGA trial, the DAN-ZOSTER trial:

https://t.co/c0cbUpAimn

In DAN-ZOSTER we will randomize 162,000 participants to assess whether a shingles vaccination may reduce the future risk of cardiovascular disease and dementia

[CTCPR Trials & CIRL @CTCPR_]

🫀Can machine learning unlock hidden signals in echo data?

New study by @JakobOeystein & @CTCPR_ (International Journal of Cardiology) applies machine learning to full strain & tissue Doppler imaging curves.

Key findings:
🤖Better prediction of HF & CV death vs. conventional echo
📈Deformation curves hold added prognostic info
🔬Potential for future risk models

Early-stage—but promising for smarter CV risk stratification.

Study link: https://t.co/yC2uxX42LE

@TorBiering
@CopCard
@RigsHeart
@HGHHjerte
@Stenodiabetes
@matslassen
@niklasdj1
@KristofferSkaar
@fwemmer1