Camillo Tancredi Strizzi

MD, Nephrology Resident at @policlinicogemelli
Currently Research Fellow at Karolinska Institutet
Science & Research Enthusiast, Part-time Musician.

[Camillo Tancredi Strizzi @CTStrizzi]

🧵1. Aldosterone isn’t just “salt & water.” In modern sodium-rich contexts it drives inflammation, fibrosis, and residual cardiorenal risk. We map physiology → disease → therapies, and argue for reprogramming the signal. Follow the thread ---> https://t.co/VLpwPTVvh8

[Camillo Tancredi Strizzi @CTStrizzi]

Hundreds of AI models for SLE. Zero FDA/EMA clearances. One used at point of care.

We asked of each: if it showed up in your clinic tomorrow, what would you do differently?

New review in Lupus, w/ @wisit661 and @FrancescoPesce Pesce.

https://t.co/bgRijG27oP

[Hans-Joachim Anders @hjanders_hans]

Now open access in @NDTsocial

CKD of unexplained cause (CKDx): A consensus statement by the Genes &Kidney Working Group of the ERA

🧐Check also our 2 open access editorials on this innovative concept.

▶️https://t.co/E3AlNE29wO

[Camillo Tancredi Strizzi @CTStrizzi]

Full paper available in open access, in collaboration with @Violadmb & @FrancescoPesce.
@IJMS_MDPI

https://t.co/Lgow4rVRAh

[Camillo Tancredi Strizzi @CTStrizzi]

Where does aldosterone actually do its work? In the aldosterone-sensitive distal nephron (ASDN): DCT2, CNT, and the collecting duct.
The control room for Na⁺ balance and K⁺ homeostasis. (Follow the thread 🧵)
#Nephpearls #Nephrology #Physiology

[Camillo Tancredi Strizzi @CTStrizzi]

3. Connecting Tubule/Collecting Duct
α-Intercalated cell
🎯 Aldo → H⁺ secretion (H-ATPase/H/K-ATPase)
β-Intercalated cell (base/Cl⁻)
🛑Aldo suppresses Pendrin (Cl/HCO₃ handling)

🧪Aldosterone excess contribute to metabolic alkalosis with hypokalemia.

[Camillo Tancredi Strizzi @CTStrizzi]

8. Aldosterone: From Essential Tubular Regulator to Pathological Driver—Physiology, Disease, and Therapeutic Advances.
In collaboration with @FrancescoPesce @DAmbrosioViola
Open Access in @IJMS_MDPI:
https://t.co/VLpwPTVvh8

[Camillo Tancredi Strizzi @CTStrizzi]

🧵1. Aldosterone isn’t just “salt & water.” In modern sodium-rich contexts it drives inflammation, fibrosis, and residual cardiorenal risk. We map physiology → disease → therapies, and argue for reprogramming the signal. Follow the thread ---> https://t.co/VLpwPTVvh8

[Camillo Tancredi Strizzi @CTStrizzi]

7. Future & biomarkers 🔬
Non-genomic pathways (GPER), NLRP3 blockade, TLR/biglycan axis, miRNA, immune re-balancing and others.
👉The goal: pathway-informed, biomarker-guided precision nephrology.

[Camillo Tancredi Strizzi @CTStrizzi]

The success paradox: better therapies → rarer events → longer, costlier trials.
Our proposal: smarter trials, not bigger, use adaptive & pragmatic designs, eGFR slope as surrogate, RWE and continue DHT monitoring.
@FrancescoPesce
https://t.co/4V4HOTWBGS

[Camillo Tancredi Strizzi @CTStrizzi]

Proud to share our new paper: a road map to redesign nephrology clinical trials by pairing modern methodology and computational tools. With @FrancescoPesce.

https://t.co/yld0y2d7JG

[Sanjeev Sethi @SethiRenalPath]

Basics of Glomerulonephritis (GN). GBM is key.

All patterns can be explained by glomerular basement membrane (GBM) & type of injury.

Let’s do one at a time

CRESCENTIC GN

1. Results from breach/break of GBM (red arrow)

2. Injury is sudden & severe

Eg-ANCA & anti-GBM GN

[F. Perry Wilson, MD MSCE @fperrywilson]

"Drink more water!" It's the easiest health advice around. Tired? Headache? Trying to be like Tom Brady? Just drink more water. But as a nephrologist, I get asked all the time: How much is the right amount? And the truth is... we don't really know. 🧵

[Tony Breu @tony_breu]

1/14
🤔 Why do we use iodine as an intravenous contrast agent?

The answer requires a review of the composition of the human body and a brief tour of one of my favorites, the Periodic Table of Elements.