Luis

hello

[Ace @MrAcezzz]

Your thyroid and your testosterone are the same conversation.

Low T3 slows SHBG clearance. Slows liver detox. Slows Leydig cell function.

Men chase androgens for years while their thyroid quietly throttles everything upstream.

Resting body temp below 97.8°F upon waking. Cold hands, cold feet, slow pulse.

Fix your hormones you idiot.

[Luis @CuentaNingun]

@JesusJm303468 @BBVA_Mex @bbva @CondusefMX Ando en las mismas, ya es demasiado tiempo y el pdo es que no te dan solución ya fui a socural y nada

[Luis @CuentaNingun]

@MMartinezordaz @angel95_23 @BBVA_Mex @bbva @Banxico Ami me dice que según el 4 de agosto

[Luis @CuentaNingun]

@JLuis656 @patyzunigav @bbva @BBVARe_mx En las mismas

[Luis @CuentaNingun]

@Berthadlg @status_is_down Ando igual

[Luis @CuentaNingun]

@Rmrezkiki @paoooosi @bbva @BBVA_Mex Ami aún nada el problema no se si ala otra persona ya le llegó ya que es una compra en línea

[Luis @CuentaNingun]

@_Hey_sweetie Algunos ya les callo su transferencia y Ami nada

[Luis @CuentaNingun]

@AlexMoo53887473 @lau_rdz1 Igual

[Luis @CuentaNingun]

@SofiaHGuridi @Luffy92558086 @SabinnaAna @bbva Igual y aún nada

[Luis @CuentaNingun]

@MarioiZarate Si

[Luis @CuentaNingun]

@itsmekenini No, estoy igual

[Luis @CuentaNingun]

@pameRoV94 @HassanObregon @Banorte_mx 😭

[Luis @CuentaNingun]

@Perla_Gd @bbva Aún no

[Luis @CuentaNingun]

@BerbarianWizard @mgomezesp_ @HansAmato Is there any way to avoid that? Aside from keeping a low dose

[Luis @CuentaNingun]

@BerbarianWizard By the way, how would T3 help with a deeper voice?

[Luis @CuentaNingun]

@BerbarianWizard @TMClash95 I guess everyone is different. I do well with just T4

[Luis @CuentaNingun]

@BerbarianWizard Thyroid hormone is way undervalued; most people just see it as a fat burner

[Morph @doctormorphh]

T3 is arguably more important for height growth than GH.

Local IGF-1 is the most important factor for height, with plasma GH having a negligible effect on local IGF-1. T3 on the other hand potentiates local IGF-1 a lot leading to more chondrocyte proliferation.

❖ T3 increases local IGF-1 in chondrocytes
❖ T3 increases IGF-1 receptor density in the growth plate
❖ T3 potentiates IGF signaling by inhibiting GSK3β
❖ T3 potentiates Wnt4/β-catenin output

Now T3 is synthesized locally in the growth plate from T4 meaning we have to look at optimizing

❖ T4 transportation into the growth plate (MCT8 and MCT10)
❖ T4 → T3 conversion (DIO2)

Lets optimize this

T4 Transportation with MCT8 and MCT10
❖ Ensure optimal T4 supply
❖ Lower tryptophan intake (competes with T4 for MCT10)
❖ Avoid milk thistle (contains sylichristin)
❖ Drink more milk (contains miR-584 which inhibits PTTGBF)
❖ Avoid dexamethasone
❖ Avoid busiperone
❖ Avoid (methyl)mercury
❖ Minimize BPA's and BPZ's exposure

T4 → T3 conversion through DIO2
❖ Avoid long caloric restriction
❖ Optimize cortisol levels
❖ Get adequate selenium
❖ Lower IL-6, IL-1β and TNF-α
❖ Avoid propanolol
❖ Avoid dexamethasone
❖ Optimize glutathione and thioredoxin
❖ Eat more carbohydrates
❖ Lower hypoxia through increasing Co2 tolerance

And ofcourse the basics like sleep, nutrition, dont bedrot etc.

If you want to know how to increase optimize T3 and T4 levels and how this hormone works read my Hormones 101 ebook

link: https://t.co/1StHMR8y43

[Abud Bakri MD @AbudBakri]

The androgen backdoor synthesis pathway was only recently discovered and acknowledge to be important in humans

Progesterone ->>>> DHT

The fact that a pathway exists that takes progesterone to androsterone/DHT should not be ignored, especially when this pathway likely falters BEFORE the main delta4/delta5 testosterone synthesis pathway, and great influences regulation of the hypothalamus-pit-gonadal axis and the hypo-pit-adrenal axis. Adrenal steriodogenesis alterations (adrenopause) predate gonadal alterations (andropause)

What happens in to your adrenals in 30s/40s is what leads to the hypgonadism of your 50s. A perfectly timed clock. For some, that clock starts earlier, and they are hypogonadal by early 30s. But zoom out even more. This starts with your pineal gland/circadian rhythmicity in your teens/20s.

In the elegant and beautiful endocrine system: adrenals regulate testicles, which makes too much sense given that high stress states should decrease fecundity

What’s the main serum marker of testicular testosteorne production and fertility? 17OH progesterone

My endocrinology textbooks still don’t highlight this key pathway, and the idea that progesterone can become DHT is mind blowing to many

There is no strong scientific evidence to the claim “DHT is not needed after puberty” and it suffers from the same hubris as “thymus doesn’t matter in adulthood”.

Sure, many men can tolerate 5AR inhibitors like finasteride, but that doesn’t prove that DHT isn’t important. These drugs aren’t able to fully lower DHT in the cell, and they may have compensatory upregulation of androgen receptors. Humans are resilient

Key point: male pattern hair loss is a disorder caused by aberrant upregulation of 5AR in scalp, not a disorder of systemic DHT excess.

Treatments should focus on figuring out why 5AR is upregulated and address that, or use local inhibition of the 5AR enzyme in those prone to MPD

And if you take a guy from a serum DHT of 25 to a serum DHT of 5… how much are you really changing

Endocrinology needs some androgen infusions. It’s getting stale and decrepit

More to come

[Hans Amato @HansAmato]

Natural hormone optimization is going to die out...
and honestly, it makes sense.

Why?
Because the results are microscopic.

Most “testosterone boosters” give you maybe +100 ng/dl increase (400 -> 500ng/dl...worth it? Nope).
Most IGF-1 boosters? +20 points if you’re lucky.

Meanwhile…
> injectable testosterone, GH, tesamorelin, DHT, androsterone, etc.
...absolutely dwarf those changes.

Natural compounds still have their place,
libido, gut health, mood, hair regrowth, recovery…

But if true optimization is the goal, then peptides or the pharmacological route is best explored (safely under expert guidance).