Covid (@UCSF) Chronicles, Day 838
The die is now cast: BA.5 is destined to be our dominant virus.
In today’s 🧵I discuss the implications on the course of the pandemic, and how to think about responding.
(I use “BA.5” & not “BA.4/5” since BA.5 is poised to outrun BA.4.). (1/25)
Today, Denmark lifted all restrictions & COVID-19 is no longer deemed a "societal threat".
I led the country's largest behavioral covid-project (@HopeProject_dk) & advised the Danish gov.
Here are my thoughts on how DK got here, what can be learned & what lies ahead.
🧵 (1/14)
Unfortunately, we've seen significant no. of pts taking ivermectin at home, coming in with severe COVID. Some of them are not even vaccinated. Please don't neglect what is a given; Vaccines work & it can save yr lives.
Real world data from CDC: mRNA vaccines efficacy against delta variant=66% (95%CI 26-84) vs Pre-delta= 91% (95% CI 81-96) https://t.co/aaZ15KmkuQ @JKJAVMY@DGHisham@KKMPutrajaya
Real world study in Guangzhou regarding efficacy of Sinovac and Sinopharm vaccines against Delta strain.
The inactivated vaccines were 70.2% effective against moderate infections and 100% against severe infections. https://t.co/tsZzXFaDyo @JKJAVMY@KKMPutrajaya@DGHisham
"We call on regulatory bodies..to conduct immediate review of the accuracy of pulse oximeters in patients of colour & to only approve oximeters proven to perform equivalently in White patients and patients of colour in clinically relevant range of 88–96%"
https://t.co/HdA40rvpUA
🚨Exciting results from the #RECOVERY trial #preprint of #Tocalizumab (Toci) in hospitalized people w/ #COVID19
-reduced 28-day mortality (29 vs 33%; NNT)
-decreased likelihood of requiring MV (33% vs 38%)
-shorter hospital stay (median 20 vs >28 days)
https://t.co/6olc1P7Ilv
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🚨Brand new ICU #OnePager 1️⃣📟 in collaboration with @MRamzyDO on #Lactate / Lactic Acidosis🧪including why it’s made, how it’s cleared (70% liver, 20% kidney), and a framework for thinking about VO2/DO2 & Type A/B/D lactic acidosis.