Daniel Maddison

Research Associate, Avezov Lab, UK Dementia Research Institute at University of Cambridge

[Avezov lab @AvezovL]

New from our lab: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity

It resolves in organelles e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule

https://t.co/7hhAu5Z0qV

[Daniel Maddison @D6Mad]

@Alvaro_MurilloB 🙌

[Cells MDPI @Cells_MDPI]

📢 #CallforPapers

🌟 #𝑺𝒕𝒓𝒆𝒔𝒔𝑺𝒊𝒈𝒏𝒂𝒍𝒊𝒏𝒈 𝒂𝒏𝒅 #𝑪𝒆𝒍𝒍𝑭𝒂𝒕𝒆�#𝑪𝒆𝒍𝒍𝑭𝒂𝒕𝒆𝑫𝒆𝒕𝒆𝒓𝒎𝒊𝒏𝒂𝒕𝒊𝒐𝒏: 𝑻𝒉��� 𝑹𝒐𝒍𝒆 𝒐𝒇 #𝑴𝒊𝒕�𝒇 #𝑴𝒊𝒕𝒐𝒄𝒉𝒐𝒏𝒅𝒓𝒊𝒂🌟

𝐆𝐮𝐞𝐬�� 𝐄𝐝𝐢𝐭𝐨𝐫𝒔:
✥Dr. Daniel Maddison and Dr. Bilal Malik

👉 https://t.co/c34rzAaXjd

#Cells #OpenAccess

[bioRxiv Cell Biology @biorxiv_cellbio]

A xeno-free protocol for rapid differentiation of human iPSC-derived microglia from the KOLF2.1J reference line. https://t.co/Bf4ILVGpy7 #biorxiv_cellbio

[UK Dementia Research Institute @UKDRI]

Image 5 of 5: AstrocytER

The endoplasmic reticulum (ER), a network of membranes through which proteins and other molecules move, is stained within astrocytes, the star shaped supporting brain cells.

7/7

[UK Dementia Research Institute @UKDRI]

Image 4 of 5: Amyloid Precursor Protein (APP) - an intracellular journey

APP produces the toxic amyloid beta protein that forms amyloid plaques in Alzheimer's disease. Researchers found that APP's location in the cell is important for how much amyloid is produced.

6/7

[Avezov lab @AvezovL]

📰Our method for probing protein aggregation in cells with Halotag/FLIM now published, by @karnika0696 & Daniel Maddison @D6Mad 🔬

https://t.co/hjh7KjqwZk

Tech we used to visualise stress-induced disaggregation in https://t.co/Gipx1LuMB2

[UK Dementia Research Institute @UKDRI]

New paper by @EdwardAvezov @AvezovL in @CellReports reveals crucial insight into the role of the endoplasmic reticulum (ER) in suppressing neuronal regeneration in the central nervous system, offering promising treatment strategies for neurodegeneration👉https://t.co/tG8ZH8Sncz

[Avezov lab @AvezovL]

🔬The endoplasmic reticulum (ER) in 3D, By Tasuku Konno. What do you notice?

[UK Dementia Research Institute @UKDRI]

Defying Dementia: Charity Livestream from the Research Lab https://t.co/8NwFEIsJHY

[Cambridge FTD @CambridgeFTD]

Inflammation, microglia and TBK1 - rapidly moving aspect of FTD/ALS.and ripe for therapeutic targetting ⁦@UKDRI⁩ #FTDUK

[Eric Betzig @Eric_Betzig]

#FluorescenceFriday #cellbiology #bioart @wonderofscience 4D organelle remodeling in dividing HeLa cells. Please expand to see greater detail.
Left: 3D volumes of chromosomes, mitochondria, and the endoplasmic reticulum (ER) in whole cells.
Middle: Inner details revealed in successive 2 micron thick slabs computationally cut though the cells.
Right: Expanded view in one slab. As the cells progress through division, mitos fragment, ER forms sheets, and mito fragments nestle into ER pockets as both organelles partition into the two daughter cells.
As seen by 4D lattice light sheet microscopy. https://t.co/vpdwTXqrdm

[Joseph Bateman @BatemanLab]

Our new paper modelling #mitochondrial disease in Drosophila is now available. UPR and #ATF4 activation in the brain depends on the severity of mitochondrial complex I loss. https://t.co/n6FgPpBx5Q

[Cell Biology J-Club @cell_club]

Motion of VAPB molecules reveals ER–mitochondria contact site subdomains
https://t.co/dOM4BdCoHk

[Cell Reports @CellReports]

Partial loss of MCU mitigates pathology in vivo across a diverse range of neurodegenerative disease models https://t.co/o1Kll4QUr7

[Natalie Connor-Robson @nlconnor_robson]

📢Job alert - Postdoc position📢 Are you excited about using iPSC-derived microglia to understand endocytic mechanisms underlying Alzheimer's? Fancy developing some cool new imaging methods? Join us! Please RT & share @UKDRI @dem_researcher @ARUKscientist https://t.co/tJ45L6p4tT

[UK Dementia Research Institute @UKDRI]

💡Closing soon: opportunity for 2x Research Assistant/Associates to join @AvezovL!

Lead an exciting project exploring pharmacological approaches to antagonise amyloidogenesis through enhancing cell proteostasis👉https://t.co/U70SAxM5fM

[Avezov lab @AvezovL]

🔬 Join our lab @Cambridge_Uni @UKDRI 🧠 and lead an exciting project exploring pharmacological approaches to antagonise amyloidogenesis through enhancing cell proteostasis.

https://t.co/aHcEFjKzMx

[Dr Ryan J Bevan @DrRyanJBevan]

Go check out my recent manuscript that we uploaded to @biorxiv_neursci.

We found that the protective variant of PLCG2 expressed by microglia in the brain preserves synaptic integrity independently from amyloid burden in an amyloidosis model of AD. @UKDRI
https://t.co/MI71sN7cYG

[Gaynor Smith @GaynorASmith]

Delighted out lastest work has been published at Cell Death Discovery! We investigated the unusual role of Cdk12 in neurons. @UKDRI @SpringerNature

https://t.co/MNrn1X9ap7