David Garfield (@[email protected] and post)

AI for Life Sciences at Anthropic. Former drug target hunter at Genentech and Bayer. Recovering marine biologist. Always an evolutionist. Views are my own.

[David Garfield (@[email protected] and post) @dagarfield]

@suragnair @sroyyors ummm...... :D

[David Garfield (@[email protected] and post) @dagarfield]

@suragnair @sroyyors Tell me more ;)

[David Garfield (@[email protected] and post) @dagarfield]

@StevenSalzberg1 It really reminds me of stories from the Herceptin data release

[David Garfield (@[email protected] and post) @dagarfield]

And then sometimes, the field just changes. How wonderful.

[Mark Lewis, MD, FASCO @marklewismd]

Cheers, chills, and a standing ovation when RASolute 302 showed unprecedented survival on daraxonrasib for patients with progressive pancreatic cancer

Seldom do you sense you’re witnessing a historic moment in cancer care but this feels like ras targeting has arrived

#ASCO26

[David Garfield (@[email protected] and post) @dagarfield]

@pgodfreysmith @birchlse @davidchalmers42 I was just thinking about you this week in my new role and wondering what Peter would have to say about LLMs...I do you hope you do some writing on this at some point.

[David Garfield (@[email protected] and post) @dagarfield]

@drchristhorpe @biohub And? How'd it go?

[David Garfield (@[email protected] and post) @dagarfield]

@peterottsjo I loved these papers. But I also have to say, the future house paper (which is well done) did highlight a target that is actually pretty well known for AMD....

[David Garfield (@[email protected] and post) @dagarfield]

this is pretty cool!

[Arjun Raj @arjunrajlab]

Code: https://t.co/7YUy1XKPUE

Also, note that this uses our new data analysis skill, mycelium, which I think is pretty cool: https://t.co/wAACzcqFiF

[David Garfield (@[email protected] and post) @dagarfield]

@MartinBJensen @AndrewE_Dunn I mean....you can make it

[David Garfield (@[email protected] and post) @dagarfield]

@alexrives Amazoing

[David Garfield (@[email protected] and post) @dagarfield]

@pkoo562 Ditto!!! Sadly, doing onboarding this week instead of the lovely conference you arranged, but very happy to chat when you're back in office.

[David Garfield (@[email protected] and post) @dagarfield]

Last week was my last week at @genentech. It was an amazing 5 years. And now...something new! I've joined Beneficial Deployments and the AI for Life Sciences team at @AnthropicAI. Looking forward to continuing science conversations in this new role.

[David Garfield (@[email protected] and post) @dagarfield]

@fabian_theis Gonna record for leading strand? I'm onboarding for the new job this week, so can't make it in person :(

[gokcen @gokcen]

Excited to share Decima, out now in @naturemethods! 🎉

Existing seq-to-function models predict bulk expression. Decima goes further: it predicts gene expression in specific cell types and disease states from DNA sequence alone — trained on 22M+ single cells.

Applications: cis-regulatory mechanisms, cell-type-resolved variant effect prediction, and designing context-specific regulatory DNA

[David Garfield (@[email protected] and post) @dagarfield]

@arjunrajlab Naw, its like a MeeSeeks.

[David Garfield (@[email protected] and post) @dagarfield]

@MichaelGalvezMD @SantaClaraUniv Often, I think the incentive structure is often to keep the number of graduates low to keep the "product" rare. There just needs to be a lot more medical schools (and PA schools, and skilled nursing schools....etc)

[David Garfield (@[email protected] and post) @dagarfield]

Money well spent

[Biz Carson @bizcarson]

A new medical school, the first in a century, is coming to the Bay Area thanks to a gift from Nvidia billionaire Mark Stevens and his wife Mary. It's a partnership between Sutter Health and Santa Clara University - two miles down the road from Nvidia HQ:
https://t.co/KBjC0Ok8f4

[David Garfield (@[email protected] and post) @dagarfield]

@MartinBJensen oh shush :)

[David Garfield (@[email protected] and post) @dagarfield]

@ScienceYael @keviv9 Stick with it. Not keeping this kind of balance was ultimately what burned me out of an otherwise pretty successful academic career (happy where I landed...but man...that was not a wise path)

[David Garfield (@[email protected] and post) @dagarfield]

@ScienceYael @keviv9 But how will you ever be successful with that attitude? ;)
(joke, if not obvious)