IsomLab

We uncover how cells sense, communicate, and exchange material, with a focus on pH sensing, intercellular communication, and the dark proteome.

[IsomLab @danIsomLab]

Thank you for sharing our work and for this thoughtful perspective on how science moves forward. It means a great deal to our team. We’re excited to see what others discover about these “superdark” proteins. Many questions still to explore!

[The Lister Institute of Preventive Medicine @ListerInstitute]

A reminder on how science works. Hypotheses, evidence, analysis, results, peer scrutiny, alternative interpretations. Rinse, repeat.
Here's a snippet of that: a recent paper on so-called 'superdark' proteins and commentary from former Lister Fellow @m_madan_babu and @nilcm9 👇

[IsomLab @danIsomLab]

@DarioAmodei Finding candidates is relatively straightforward, with or without Claude. Extensive experimental validation and rigorous peer review are the hard parts. For context, see Fanzor, Cas13an, and our TM184C work:
https://t.co/rzMGGMHYUM
https://t.co/FCsJWnPzhD
https://t.co/EkE584rOQL

[IsomLab @danIsomLab]

@nc_frey Finding candidates is relatively straightforward, with or without Claude. Extensive experimental validation and rigorous peer review are the hard parts. For context, see Fanzor, Cas13an, and our TM184C work:
https://t.co/rzMGGMIwKk
https://t.co/FCsJWnQ77b
https://t.co/EkE584smGj

[Michelle Monje 🟦 @michelle_monje]

Brain cancers take advantage of neural circuit activity. Re-purposing an anti-seizure med called levetiracetam disrupts an important neuron-cancer interaction in #DMG #DIPG, slowing growth and extending survival in mice and retrospective patient data.
https://t.co/XTXKkDyt90

[Adrian Dobbelstein @AdrDobbel]

Happy to share our preprint: "A Unified 3D Generative Model for Synthesizable Structure-Based Drug Design". Highlights, preprint, and code below: 🧵1/10

[Melodies & Masterpieces @SVG__Collection]

67 years ago today, ‘Take Five’ by Dave Brubeck Quartet was released as a single.

It went on to become the best-selling jazz single of the 20th century.

[Ariax Bio @AriaxBio]

BindCraft2 from the @MartinPacesa lab is here and available now on Ariax!

We called BindCraft a “DeepSeek moment” in protein design. BC2 builds on that proven foundation with major speed improvements and a much broader range of therapeutic formats.

https://t.co/DfblZW5jsL

[IsomLab @danIsomLab]

Snuck onto the cover of Nature. Not a bad place for a “superdark” protein to end up. Very grateful. Much deserved Kyutae Lee, Sam Taylor, PhD, Jennifer Arcuri, Ph.D., Shraddha ChandThakuri, Bruno Colon, Jacinda Pujols, and others.

[IsomLab @danIsomLab]

There are more.

[IsomLab @danIsomLab]

What is a superdark protein?

[IsomLab @danIsomLab]

That’s how we found a potentially very important human protein hiding in plain sight in our bodies.

[IsomLab @danIsomLab]

Thank you, Nil and @m_madan_babu, for your cool commentary on our recent Nature paper. Very well done!

The paper: https://t.co/WaoxWEBlXX

The commentary: ‘Superdark’ protein looks like a G-protein-coupled receptor — but shows unconventional behaviour https://t.co/90gC1QlHHC

[IsomLab @danIsomLab]

@LavivTal Thanks, Tal. Looking forward to collaborating!

[IsomLab @danIsomLab]

Out online today in @Nature. The known protein universe holds hundreds of millions of members, yet most remain unexplored, a vast biological darkness that may hold important clues to human health and disease. We went looking in it.
https://t.co/EkE584rOQL

[IsomLab @danIsomLab]

@MoKhalilLab @Nature Thanks! @MoKhalilLab

[IsomLab @danIsomLab]

Supported by an NIH R35 award from @NIGMS, @SylvesterCancer, and the @Pap_Corps, through my endowed chair. Thanks also to Steven Dwoskin, whose recent gift supports what comes next.

[IsomLab @danIsomLab]

And the people in those labs: Chenzhou Wu, Sebastian Thompson-Ceccato, Qiang Wang, Tatiana Slepak, Jonathan Mitchell, Alexandra Carbone, and Dazhi Wang. High-performance computing by Warner Baringer and Elvis Maradzike of @UMIDSC.