Dan Foley

Organic chemistry research and teaching at the University of Canterbury @UCNZ. Opinions mine.

[Dan Foley @dan_fol]

I'm pleased to share our latest paper, out now in Advanced Synthesis and Catalysis!:

https://t.co/YTdkcYKyF4

Congratulations to all involved! @AggieLawer @finlayplayer at @UCNZ @UCNZ_PhysChem and Dist. Prof. Vicky Avery @GRIDD_GU

[Making_Molecules @nz_molecules]

Re-inventing the wheel. Instead of a #ChemEd #Chemistry summary, here is my attempt at a pKa (in H2O) scale. Values are taken from the Evans/Ripin & Hans Reich resources. If you want a table, I recommend these. This was an attempt at a more visual representation of the same data.

[Sebastian Cosgrove @scosgrove123]

PhD available!! Join me and Peter Matthews at @keelechem for a truly interdisciplinary project using new technologies to create inorganic 2D materials! Lots of travel and consumables to support! Deadline 17/02/25!

https://t.co/yQSGv8HTSM

[Baran Lab @BaranLabReads]

Finally, RADICAL CROSS COUPLING without the exogenous REDOX. We disclose in @ChemRxiv (https://t.co/FYy6i1J7p9) a broadly general platform for achieving transformations that normally required excess metallic or chemical reducing agents or photochemical setups (and their requisite catalysts) or potentiostats for electrochemistry. Now, such transformations can be accomplished with the same ease that one conducts a Suzuki coupling. You can scale up (its homogeneous) or scale down (use cheap parallel screening plates). Moisture is tolerated and base metal catalysis is used. As the best engineers like to say, "The best part is no part". Now, chemists have the option to remove the redox part from radical couplings.

Quick Summary: Sulfonyl hydrazides are disclosed as versatile radical precursors as exemplified with seven new C–C bond forming, redox-neutral cross-couplings with: (1) activated olefins, (2) alkyl halides, (3) redox active esters, (4) aryl halides, (5) alkenyl halides, (6) alkynyl halides, and (7) a trifluoromethylating reagent to forge C(sp3)-C(sp3), C(sp3)-C(sp2), and C(sp3)-C(sp) bonds. Sulfonyl hydrazides are stable and usually crystalline substances that can be accessed in a variety of ways including transiently from hydrazones to achieve a net reductive arylation of carbonyl compounds. Exogenous redox (chemical, photo/electrochemical) additives are not necessary as these functional groups serve the dual role of radical precursor and electron donor. The operational simplicity (homogeneous, water tolerant, dump-and-stir) and practicality of the method are demonstrated as well as applications to streamlining synthesis and mild late-stage functionalization.

[Adam Nelson @Adam_S_Nelson]

Interested in high-throughput chemistry, chemical biology and kinases? @MWrightLab @baylisslab and I are recruiting a PhD student as part of a collaborative team to work in this area! https://t.co/8xQnTBS64u

[Dr Will Unsworth @UnsworthChem]

There is still time to apply for our fully funded (Marie Curie) PhD project on the synthesis of medicinally important macrocycles @ChemistryatYork

Open to students worldwide🌍(for anyone NOT primarily living in the UK in the last 3 years)

apply via 👇
https://t.co/FbbxLKfjXb

[Sebastian Cosgrove @scosgrove123]

Newest paper up in @JOC_OL! Last of Alice's PhD and first of @liambfarm, with @Rob_Field_Lab and @millerrschgroup. We show a one-pot biocat-Wittig cascade reaction, all in water! Neat scope and up to 1 mmol. Well done Alice and Liam!

https://t.co/eF9RsHlcV5

[George Karageorgis @GeorgeK_86]

Here's the peer-reviewed version of our study into the change of molecular complexity over time @AstraZeneca Macclesfield. We examine many metrics and discuss how they compare and could be used. We also show applications in FDA historical data. https://t.co/vlzKDy0PTG

[Luca Laraia @laraialab]

Second pre-print of the week!🥳This time @ChemRxiv we discover a funky 3D spirooxepinoindole core as a privileged scaffold for inhibiting sterol transporters! 1/n https://t.co/bs9kvoYhJ8

[Luca Laraia @laraialab]

NEW pre-print! Endogenous and fluorescent sterols reveal the molecular basis for ligand selectivity of human sterol transporters. Fantastic work by @Laura_dta with support from @HoganBryceRoge1, @NienkeJDekker, Anna and Nicolo! 1/n https://t.co/z0mh8bm3Mr

[Dan Foley @dan_fol]

@laraialab @MaxCaplin Thanks Luca!

[Dan Foley @dan_fol]

I'm pleased to share the latest work from our team!

We report an approach for site-specific heteroarylation of bridged bicycles, with a view towards being able to reliably develop of 3-D fragment compounds.

Thanks to @MaxCaplin and Imogen for their hard work on this!

[EurJOC @EurJOC]

Directed Arylation of 7-Oxabicyclo[2.2.1]heptane to Prepare 3D Fragments by Daniel J. Foley and co-workers #openaccess (@UCNZ) https://t.co/BP6JqJyqxl

[Dan Foley @dan_fol]

@GeorgeK_86 @MaxCaplin Thanks George! 🙂

[Anna McConnell @annajmcconnell]

Applications are open for one more week for a PhD position in supramolecular chemistry to join our group. Apply by 31.7 using the links below
https://t.co/eNZZValOrW… (English version)
https://t.co/PWkPvHdy0G… (deutsche Version)

[EurJOC @EurJOC]

Directed Arylation of 7-Oxabicyclo[2.2.1]heptane to Prepare 3D Fragments by Daniel J. Foley and co-workers #openaccess (@UCNZ) https://t.co/BP6JqJyqxl

[Max Caplin @MaxCaplin]

Pleased to be able to share some work from my PhD.

Thank you to @dan_fol and Imogen for their hard work in getting this published.

@UCNZ @UCNZ_PhysChem

[NZIC @_NZIC]

Come and join us in our host city of Otepoti Dunedin this November for the biennial New Zealand Institute of Chemistry 2024 conference (NZIC-24). Registration and Abstract Submission are now open via the website: https://t.co/zEKsuTP5Mh
#nzic24 #nzchem

[The Gamble Lab @gamble_lab]

Ever wanted to visit the South Island of New Zealand?

Join us for NZIC-24 in Dunedin https://t.co/JXayXFoVqW

📢 November 24-28, 2024
Submit your Abstracts by 15 July 2024
Please RT #nzic24 #nzchem

[Richard Doveston @RichardDoveston]

Check out the fully funded PhD position available here @Leicesterchem! Great opportunity to join a fantastic research community. Deadline for applications is 22nd April. Contact the supervisors or myself for more information. https://t.co/fAq1jp6ZaW

[Steve Marsden @s_marsden]

Come and join us @chemleedsuni
- lectureships in digital, computational materials, chemical biology and atmospheric chem - two weeks till closing!

https://t.co/8QDyJtSKyL

[Luca Laraia @laraialab]

New paper in Bioorg Med Chem on degraders of the sterol transport protein Aster-A! We use the pomalidomide core as a fluorescent handle to determine binary binding constants, develop competitive assays, determine cell permeability + degrade Aster-A! 1/n https://t.co/6ZUCs5aKKC