Dan Prick

💯

[Jack | amatica health @JackHadfield14]

Brain-retraining logic applied to a broken leg to show how illogical it is:

Stumble, notice the leg, get anxious about standing, avoid standing, standing feels harder, avoid it more.

Conclusion: no fracture, just a fear-avoidance loop. Reassurance and graded standing will fix it.

[MECFS, MCAS and PTSD @FatigueMe92484]

Sleep / Deep Sleep / NREM / Mitochondria

2010 study by Dworak and colleagues demonstrated the mechanism: sleep triggers a region-specific adenosine triphosphate surge in wake-active brain areas, including the basal forebrain and frontal cortex. The magnitude of that surge correlates with non-rapid eye movement delta activity — the deepest phase of restorative sleep. Sleep deprivation fully prevents the surge (Dworak et al., 2010). The restorative function of sleep is the adenosine triphosphate recharge. If mitochondria cannot execute oxidative phosphorylation efficiently, the sleep-triggered adenosine triphosphate surge is blunted or absent, meaning subjective rest occurs without the cellular restitution that makes it resorative."

https://t.co/PeloMYAEGR

[Sam Stoffel @sam_stoffel]

Founder of lululemon on what he'd tell every 25 year old:

"I'd tell them that every person in the world is an individual with a different genetic makeup and a different upbringing and the way that you're thinking is so radically different than every other person in the world and incomparable that if you have an idea and you want to move forward with it, don't worry so much about the competition because nobody will be able to replicate you and the way you think about it."

[Dan Prick @dan_prick]

@c3vvno Yes

[Dan Prick @dan_prick]

@celestialbe1ng Reduced slow wave sleep isn’t worth it for me… but everyone has different genetics and responses. My sleep quality notably declines regardless of the time I use caffeine. https://t.co/TDmYxUfN7b

[Megan Stevenson @MeganTStevenson]

Just wrote this letter to the editor at Wired about that dumb article. Seriously, who made the call to publish an article on long covid written by a religion professor with no relevant expertise or qualifications??

[Julia Marie @julia_doubleday]

@AlanLevinovitz Let’s start with the fact that you claim that all the (thousands) of studies showing biological issues following Covid infections are “too small” and then you claim “mind body therapy” works based on AN ANECDOTE lmfao

[Megan Stevenson @MeganTStevenson]

Turns out I was featured in this very dumb article about long covid. And the guy lives in my small town and didn’t even reach out to ask for my perspective! Just sent him this email.

[Lukas A. @Amludude]

@Retired_Twink @stopizz Toxicology testing is currently underway and should be completed by next month or by September. Only after that can Phase 1 begin, which will involve testing in humans.

[MECFS, MCAS and PTSD @FatigueMe92484]

Endotoxin exposure or TNF-a suppresses CLOCK long after the challenge or peak of TNF-a. This suggests mast cell activation can alter circadian rhythm.

[Putrino Lab @PutrinoLab]

WILD finding. So what does it all mean? First and foremost, if samples from your blood can make someone sick, then we need not have conversations about the legitimacy of this diagnosis any more.
5/

[Prof. Akiko Iwasaki @VirusesImmunity]

Excited to share our study by @keylas3 et al. on pathological autoantibodies in people with Long COVID. We asked whether IgG in patients with Long COVID bind to human tissues/antigens and cause pathologies when transferred into mice. With @PutrinoLab

https://t.co/tcowCufWyf

[MECFS, MCAS and PTSD @FatigueMe92484]

Astrocytic NE signaling serves as a critical local feedback mechanism to stabilize the brain. During high arousal, NE activates astrocytes, which eventually release sleep-promoting adenosine to bring the cortex back into a balanced, synchronized state. Inhibiting this signal prevents astrocytes from driving this restorative transition, disrupting the seamless shift between wakefulness, focus, and sleep.

Norepinephrine–Astrocyte Signaling Regulates Cortical State Homeostasis - PMC https://t.co/75SW03oXqr

[ME/CFS Science @mecfsskeptic]

1) There's an interesting lead in the ME/CFS genetic data: the eccentric medium spiny neuron (eMSN), a cell type in the brain discovered only a couple of years ago.

All based on preliminary findings, but the data looks rather interesting.

[Dan Prick @dan_prick]

@mecfsskeptic A lot of this research is over my head as a layman reader and patient, but I have a different feeling about this one… Neurotransmission dysfunction tracks with my experience. Very curious where this leads and what treatments could be used.

[ME/CFS Science @mecfsskeptic]

28) So the hypothesis is that these eMSN might be overactive in ME/CFS and produce too much CRH.

This might inhibit other CRH-producing cells, including those in the hypothalamus, and lead to epigenetic silencing. This would make it look like the CRH neurons are no longer there.

[Chris Werge @chriswerge]

I am. It's been the most helpful out of all meds I've tried for Long Covid. Been out it a total of 12 months now and have been able to manage a 5day work week again. Still have pain and aches around the body but the best I've felt in 4 years.

[Adam @ABrokenBattery]

Chronic Fatigue Syndrome is a terrible name for a disease. It does not convey the severity or the nature of the condition.

“It trivialises and stigmatises the illness.” - Dr Anthony Komaroff

Repost for #MEAwarenessMonth - now optimised for phones.

[Jason S @JasonS1269]

If you do gardening, cooking, etc, please stop identifying as bedbound.
No wonder the general public doesn't understand how gravely ill some of us are.