Daniel J Drucker

A clinician scientist at LTRI @sinaihealth studying GLP-1, diabetes, obesity and the gut endocrine system Proud 🇨🇦Not going anywhere Am 🇮🇱Chai

[Daniel J Drucker @DanielJDrucker]

How do GLP-1 meds improve liver health through #weightloss independent mechanisms? Here @ChusaGzlzRellan & colleagues identify Liver Sinusoidal Endothelial Cells as direct targets of semaglutide, linking LSECs to reduction of #inflammation #Fibrosis #MASH https://t.co/c5FXIs2hTO

[Daniel J Drucker @DanielJDrucker]

Retatrutide and the improvement of obstructive sleep apnea https://t.co/WB1R6UYQ9R

[Eric Topol @EricTopol]

GLP-1 peptides protect the gut from immune injury.
Essential role of endogenous GLP-1 family peptides to reduce inflammation and restore mucosal integrity in the experimental model @DanielJDrucker @CellRepMed
https://t.co/oE0Z1VQ98m

[Daniel J Drucker @DanielJDrucker]

Will GLP-1 medicines be useful in the clinic for substance use disorders? We will soon find out @marilenharo https://t.co/QlkV8np2Xm

[Daniel J Drucker @DanielJDrucker]

This Friday 8 am @SinaiHealth @uoftmedicine in Toronto, the 2026 Burrow Lecture, 8 am, Professor @cevansmo #Diabetes #islets

[Daniel J Drucker @DanielJDrucker]

Over 6 weeks in people with MASLD inhibition of fructose metabolism has beneficial metabolic effects that extend beyond the organs that metabolize fructose @NatMetabolism
https://t.co/WGyXosMt11

[Daniel J Drucker @DanielJDrucker]

Here the authors propose that a gut microbial aldehyde-alcohol dehydrogenase, AdhE, converts metformin to pharmacologically inactive products, lowering intestinal and systemic drug exposure https://t.co/EayLc1u8i9 @Cell_Metabolism

[Daniel J Drucker @DanielJDrucker]

New P3 data for the oral small-molecule GLP-1 receptor agonist safiglipron in early type 2 diabetes in China @NatureMedicine
https://t.co/bpBjKKUdB1

[Daniel J Drucker @DanielJDrucker]

Genetic variation and type 2 #diabetes New perspectives @MolMetab https://t.co/ORqJr9hUYX @DiabetologiaJnl

[Max Kozlov @maxdkozlov]

SCOOP: Top researchers at Columbia, Stanford, and others thought they were elected to elite scientific societies alongside Nobel laureates. The catch? The organizations are a sham.

I spent the last month investigating a massive academic scam, for @Nature

https://t.co/cV4twhUrQF

[Daniel J Drucker @DanielJDrucker]

A childhood window into genetic variation linked to childhood adiposity @NatureGenet https://t.co/3kzEx5UleZ

[Daniel J Drucker @DanielJDrucker]

@Roche notches impressive P2 data for the GLP-1R-GIPR co-co-agonist Enicepatide #T2D #weightloss https://t.co/UCKoTzYd1j

[Daniel J Drucker @DanielJDrucker]

@TheEndoSociety has posted a new document published in Endocrine Reviews and free to read: Obesity science, research gaps, and opportunities in the new era of obesity medicines: an Endocrine Society scientific statement @EndoSocJournals https://t.co/1N24p8s0im

[Daniel J Drucker @DanielJDrucker]

Cohort studies across the lifespan for type 2 #diabetes Progress, clinical implementation and future directions @DiabetologiaJnl https://t.co/IR7eLrbuYo

[Daniel J Drucker @DanielJDrucker]

Here the authors identify the glucagon-PKA-PDE2A-NCLX signaling axis as a key metabolic rheostat integrating mitochondrial calcium dynamics with lipid homeostasis, providing a promising therapeutic target for MASLD @MolMetab https://t.co/10bYyBqpJ4

[Daniel J Drucker @DanielJDrucker]

The weight loss proteome in mice https://t.co/fWdLuCyjeq @NatMetabolism

[Daniel J Drucker @DanielJDrucker]

In an open label study for up to 26 weeks, dulaglutide was associated with greater improvements in glycaemic control and variability compared with insulin among adolescents with transfusion-dependent β-thalassaemia (TDT)-induced diabetes @DiabetologiaJnl https://t.co/p7gdOuSu0z

[Daniel J Drucker @DanielJDrucker]

From TMAO to DNICs the expanding concepts linking microbiota metabolism to cardiovascular and metabolic pathways. Modulating DNIC formation by the gut microbiota could be a strategy to support cardiometabolic health @CellCellPress https://t.co/lfIsecTruU

[Daniel J Drucker @DanielJDrucker]

New studies in Drosophila and mice redefine the intestinal muscle as a responder to specific signals that adjust adult organ (intestine) features and sustain reproductive demands.
https://t.co/gZyBZbf14z

[Daniel J Drucker @DanielJDrucker]

A framework identifying ten priorities in #T2D prevention, toward context-specific, actionable interventions capable of altering the natural history of disease early in the life course and restoring metabolic health. https://t.co/P6fkgvy8T8

[Daniel J Drucker @DanielJDrucker]

The decades long quest for reprogramming islet cell phenotypes #diabetes continues here using a metabolic pathway approach https://t.co/x1qKBkIQrn