Proud of our @DR_E_A_M Challenge paper dissecting methods to identify disease modules in molecular networks https://t.co/EwsjmHAQDE
Joint work of >400 participants, data providers and organizers... collaborative science at its best, honored to be part!
This @DR_E_A_M challenge compares 75 methods for the identification of disease modules from network data. Users will learn about practical guidelines for how to choose a method and about benchmarks for the analysis.
https://t.co/UgvEh2qlb8
https://t.co/EwsjmHAQDE Lesson #5: Network modules reveal core disease genes and pathways.
While 1000s of genes may show disease association in GWAS, much more specific disease modules comprising only dozens of genes can be identified within networks.
Proud of our @DR_E_A_M Challenge paper dissecting methods to identify disease modules in molecular networks https://t.co/EwsjmHAQDE
Joint work of >400 participants, data providers and organizers... collaborative science at its best, honored to be part!
https://t.co/EwsjmHAQDE Lesson #4: First, identify modules in each network individually, without merging them.
Methods attempting to reveal integrated modules across networks failed to significantly improve predictions, likely because our networks were not sufficiently related.
Provided unpublished molecular networks by different collaborators were essential success of our @DR_E_A_M challenge on Disease Module Identification. 👏👏👏 https://t.co/g6wH05a2xg
Glad to be part of the DREAM Consortium for the contribution titled "Open Community Challenge Reveals Molecular Network Modules with Key Roles
in Diseases"
https://t.co/l7Yivs8A40