Dan Singleton 🏳️‍🌈🏳️‍⚧️

Organic Chemistry Prof, Texas A&M, Isotope Effects, Dynamic Effects, AC Cope Scholar, TAMU AFS Awards In Teaching and Research, Well Fargo Honors Mentor of Year

[Dan Singleton 🏳️‍🌈🏳️‍⚧️ @dasingleton]

As local ACS chair in 1999, I got to host the banquet when Alex won the Cotton award. The night's highlight for me was talking with him about music, where his knowledge of course put mine to shame. Every time I tell undergraduates about Borodin and the aldol, I think of him.

[College of Chemistry @UCB_Chemistry]

Beloved colleague and prolific scholar, Alexander (Alex) Pines has passed away https://t.co/5ytRnaEF5O

[FriendlyKozak @KvotheTheArcane]

The mashup we didn’t need and I’m sorry for making.

[Dan Singleton 🏳️‍🌈🏳️‍⚧️ @dasingleton]

but I interpret her early career moving from Illinois-UC to Madison to Jewish General Hospital and McGill as her pursuit of the best opportunity to do her science. This was not somebody who just wanted a job. Ultimately LBNL let her be an NIH PI and do her best work.

[Dan Singleton 🏳️‍🌈🏳️‍⚧️ @dasingleton]

I guess I understand why Kamala Harris only talks about her mother, Shyamala Gopalan, as a mother, but there is something missing, almost disrespectful. Because Shyamala Gopalan was an awesome scientist. And science was clearly a great passion to her.

https://t.co/Gilcfq58qS

[Dan Singleton 🏳️‍🌈🏳️‍⚧️ @dasingleton]

imagine how she managed it. Science is hard enough with every advantage. Gopalan was cranking out beautiful work with usually a single student coauthor.
Gopalan got her Ph.D. from Berkeley in 1964, after moving from India and starting grad school at age 19! I don't know but

[Dan Singleton 🏳️‍🌈🏳️‍⚧️ @dasingleton]

@JoshGoodman_BU No. No no no no no.
Suspension from journal for five years, minimum, plus notification of institution. If funding sources are listed, notification of sponsors.
Police science or lose it.

[Dan Singleton 🏳️‍🌈🏳️‍⚧️ @dasingleton]

@yunus_turkmen @PeONor So I suppose y'all write 5 arrows to move the proton in MeC(=O)CH=C(OH)Me - a reaction that is nearly barrierless. I get it, but I write 3.

[Dan Singleton 🏳️‍🌈🏳️‍⚧️ @dasingleton]

Five curved arrows at once is not a mechanism. It is a conspiracy theory.

[Dan Singleton 🏳️‍🌈🏳️‍⚧️ @dasingleton]

@RacicotLeanne I want one too.

[Dan Singleton 🏳️‍🌈🏳️‍⚧️ @dasingleton]

@yunus_turkmen I write that with 4.

And I describe that as an ‘exception that proves the rule.’ The proton transfer is very asynchronous, an afterthought versus the main bonding changes. JACS 1997 119 3385.

[Dan Singleton 🏳️‍🌈🏳️‍⚧️ @dasingleton]

@awhspeed I have published on a 6+4, but that was also a 4+2 at the same time. Ah, another conspiracy theory that is correct, proving that they all are correct and that conspiracy theorists are not just nuts.

[Dan Singleton 🏳️‍🌈🏳️‍⚧️ @dasingleton]

Getting it out in 17 months was an absolute miracle. There is a long list of chemists in Pharma who in a fair world would be hailed as heroes. I salute them.

[C&EN (Chemical & Engineering News) @cenmag]

Carlos A. Martinez, director of @pfizer’s Biocatalysis Center of Excellence, helped scale up production of a key component of the COVID-19 antiviral Paxlovid. Learn more about his work in biocatalysis in C&EN's 2024 Trailblazers issue: https://t.co/Fp1k7spqNE #LatinxInSTEM

[Dan Singleton 🏳️‍🌈🏳️‍⚧️ @dasingleton]

@emily_m_arndt We all have big egos - how else do you tell a student about an exciting project that you know might not work? Luckily, most of us are ignored if we go off the rails.

[Dan Singleton 🏳️‍🌈🏳️‍⚧️ @dasingleton]

By, uh, letting him blast nonsense about areas where he knows nothing?

[Chemistry World @ChemistryWorld]

‘A high that I likened to 10 double espressos…’ - Michael Levitt, winner of the 2014 Nobel prize in Chemistry. Over the past 2 decades, we've spoken to 12 chemistry Nobel laureates. In anticipation of next week, here's how it's affected their lives:
https://t.co/CpPPs76GG9

[Dan Singleton 🏳️‍🌈🏳️‍⚧️ @dasingleton]

@TexasTribune A 2019 state law requiring schools to offer full-day pre-K is saving parents hundreds of millions of dollars.
FIFY

[Dan Singleton 🏳️‍🌈🏳️‍⚧️ @dasingleton]

@philosofern @leecronin I did once have an undergraduate think they could stop a homogeneous reaction by turning off the mixing. So hard not to lol. Time goes on anyway. But heterogeneous reactions may stop entirely without mixing. Lee’s mix then makes sense to me, but separate from time or add.

[Dan Singleton 🏳️‍🌈🏳️‍⚧️ @dasingleton]

@ayusmansen LOL

[Dan Singleton 🏳️‍🌈🏳️‍⚧️ @dasingleton]

Oh, a related story that I tell: there is a graph in the Jurassic Park book that is completely LOL for anyone who has made a histogram from real data. Crichton liked to pretend he knew science, but actually doing it makes a difference.

[Dan Singleton 🏳️‍🌈🏳️‍⚧️ @dasingleton]

A short science lesson. The histogram of murders vs year in Springfield is indistinguishable from random noise. Any interpretation of this data is the equivalent of seeing a dog in the clouds.
For comparison, the graphs I show below are based on a random-number generator.

[Daniel Dale @ddale8]

So where did he get “murders are up by 81% because of what Kamala Harris has allowed to happen to this small community”?

His team says he was comparing…the 2023 # (9 murders) to the 2021 # (5).

That’s an 80% increase. But, uh, many issues here: https://t.co/ZN9sniFTBh

[Dan Singleton 🏳️‍🌈🏳️‍⚧️ @dasingleton]

for any interpretation of any kind. Small data sets provide ample opportunity for cherry picking (and cherry picking is a long-favorite way for people to lie with the 'truth'), but even if you are trying to be truthful, you probably need 100x as much data to say anything.