Molecular Information Systems Lab

[Keisuke Motone / 元根 啓佑 @KeisukeMotone]

Thank you for highlighting our paper
https://t.co/7ZKK9gwMCj

[Allen School @uwcse]

Towards the "holy grail" of being able to sequence individual full-length proteins to better understand and treat disease: In @Nature, a team of researchers led by @UW @UWAllen @datamolecules' @jeffnivala introduced a new method using @nanopore technology: https://t.co/4AVOKQeh1N

[Keisuke Motone / 元根 啓佑 @KeisukeMotone]

I like the title. Thank you @aksimentievLab for a nice summary of our work

Thread, read, rewind, repeat: towards using nanopores for protein sequencing https://t.co/Hgd5l3G4wY

[Jeff Nivala @jeffnivala]

Published today in @Nature, we describe an approach for single-molecule protein reading on @nanopore arrays. By utilizing ClpX unfoldase to ratchet proteins through a CsgG nanopore, we achieved single-amino-acid sensitivity. https://t.co/ZTFNZkwpcj

[Alan Boyle 👽 @b0yle]

Milestone #Peregrine moon lander mission targets an otherworldly frontier for #DNA storage: https://t.co/TcPpBYky66 H/T @astrobotic @datamolecules @celestisflights @ulalaunch @nasa @goLifeShip @archmission #PM1 #Cert1 #CountdowntoVulcan

[Allen School @uwcse]

“Incredibly mind-expanding”: That’s what #UWAllen’s @luisceze had to say about today’s moon launch of @archmission’s Lunar Library II, which includes a DNA archive of images submitted by people of Earth to @UW @datamolecules #MemoriesInDNA project: https://t.co/aqUOBj5mzZ 🚀🧬1/4

[GenomeTDCC @GenomeTDCC]

🚨Pre-Print Alert🚨
Single-molecule protein sequencing is the next frontier in sequencing technology.
Latest from @jeffnivala and colleagues - reading hundreds of amino acids and PTMs along protein strands AND re-read multiple times w/@nanopore arrays! 👇https://t.co/HrcqsWVyHC

[Jeff Nivala @jeffnivala]

Yesterday we released our preprint showing how a @nanopore array morphs into a protein sequencer... Achieving LONG reads (hundreds of amino acids) and the capability to re-read individual molecules multiple times, all thanks to a protein-processive molecular motor.

[Keisuke Motone / 元根 啓佑 @KeisukeMotone]

Our preprint is out! We hacked the @nanopore sequencer to read amino acids and PTMs along protein strands. This opens up the possibility for barcode sequencing at the protein level for highly multiplexed assays, PTM monitoring, and protein identification!
https://t.co/hVdNFa7ti4

[Jeff Nivala @jeffnivala]

ONE PORE TO RULE THEM ALL! @AshPaigeSteph and I had fun writing this news and views piece on groundbreaking work by @ScienceCaroloni, @IvanovGroup, @EdelResearch. Detection of 40+ biomarkers, from proteins to small molecules, using a single @nanopore flow cell + barcoded aptamers

[Allen School @uwcse]

Whether he’s working with chords or with code, @UW #UWAllen B.S./M.S. student Sidharth Lakshmanan puts collaboration center stage. As a 2023 @uwengineering Dean’s Medalist for Academic Excellence, you could say he hits all the right notes 🏅: https://t.co/NuBjOVmk4B #ThisIsUW

[GenomeTDCC @GenomeTDCC]

⏲️There's still time to register!! (FREE)

SINGLE-MOLECULE PROTEIN SEQUENCING webinar happening this Friday, May 19 at 11 AM EDT

SPEAKERS:
Jag Swaminathan, @erisyon
Jeff Nivala, @UW
Giovanni Maglia, @univgroningen

👉https://t.co/bQMRL6w1mr

[Molecular Information Systems Lab @datamolecules]

We are very excited to see MISL undergraduate researchers Kyvalya, Sangbeom, Zoe, and Derek present at the University of Washington’s Undergraduate Research Symposium tomorrow, Friday May 19! More information is in the proceedings at https://t.co/ngCwQyDakE. #HuskyResearch

[Engage Science @EngageScience]

Samantha gets DNA molecules to do math – She is making DNA calculators that can go into blood samples and diagnose for disease directly, without the need for expensive equipment.

Come learn more at our 3rd Science Now talk 5/10/23 @ 5:30PM at @THSEA
https://t.co/Ti65Q4r6bh

[Engage Science @EngageScience]

"What do you think of when you hear the phrase 'DNA'? Testing services like ancestry .com and 23andme? The hit songs by BTS and Kendrick Lamar?"

Read more from "DNA Origami: Life Imitating Art" Samantha Borje here: https://t.co/J9JIlTIUxm

[Allen School @uwcse]

After planting early seeds of a career in theoretical physics, #UWAllen @uw_ece professor Georg Seelig branched out into DNA computing. He was recognized with the 2023 #ISNSCE Rozenberg Tulip Award—a.k.a. “DNA Computer Scientist of the Year”—for his work: https://t.co/59QNJiUR30

[Nature Methods @naturemethods]

A Comment by @KeisukeMotone and @jeffnivala highlights the challenges of fully decoding amino acids and their modifications using protein nanopore sequencing technology, and discusses its unique potential for single-cell proteomics.
https://t.co/RnGrtPscSD

[Jeff Nivala @jeffnivala]

We look towards a future of nanopore protein sequencing when single-molecule meets single-cell. scPeptide-barcoding, full-length protein reads, and “near-pore” processing…

[Lee Organick @LOrganick]

New PhD thesis just publicly dropped (see if you can spot the pun).
If you've always wondered about DNA data storage but don't know much about it, pages 1-4 might be helpful! https://t.co/3kbwlr9qMk

[Georg Seelig @seeliglab]

Very excited for MP3-seq, a new high-throughput Y2H approach we use to screen de novo protein heterodimer interactions. Fantastic work by Alex Baryshev, Alyssa La Fleur, @benjaminbgroves,@CirstynMichel, David Baker @UWproteindesign, @AjasjaLjubetic
https://t.co/5JPKw5Ly2m