David Cutler

Population geneticist

[David Cutler @david_j_cutler]

Did you ever wonder how good any disease predictor based entirely on genetic data could be? Answer: it is a function of the heritability of the markers used, and might not be very high, without ~all~ the genetic variants identified. Figure 5. https://t.co/UagDPg6ZAH

[David Cutler @david_j_cutler]

Did you ever wonder why polygenic risk scores seem so hard to interpret across populations? Answer: it is almost all due to allele frequency and LD differences. https://t.co/UagDPg6ZAH

[David Cutler @david_j_cutler]

@jaascensao @ohallats And yeah, formally a predator adapting to genotypes of the population you are studying is a form of fluctuating selection over time. Unless you can rule out the presence of un-seen predators this is probably best explained population genetically as fluctuating selection.

[David Cutler @david_j_cutler]

@jaascensao @ohallats This sure looks like a slightly time-lagged Lotka-Volterra dynamic to me. The natural explanation is there is some genetic variation between your bar-coded clones. A bacteriophage is in your system. It adapts to prey on the most abundant clone. Clone declines. Repeat.

[David Cutler @david_j_cutler]

Ever wondered what a first principles derivation of all quantitative genetics with special application to human genetics would look like? https://t.co/9YsgDsyFCc
Later, we will describe why PRS seems so odd sometimes, and after that where all the missing heritability went.

[David Cutler @david_j_cutler]

@jimrobenalt Mr Robenalt, I was fascinated by your excellent article in Vanity Fair. I was hoping to email you about it. May I? I am not generally thought to be crazy or a nuisance. My email can be found here https://t.co/IZUvOLgyBE

[David Cutler @david_j_cutler]

@EpsteinStatGen Over 6 months from Science. They made no decision for 2 months, and then sent it out for review. They got back glowing reviews and then told us "I'm sorry. We never meant to send this out for review." It was ~2000, and I think the last time I submitted to Science.

[David Cutler @david_j_cutler]

I was a UC graduate student in the mid 1990s. One contribution to my ability to succeed as a student was labor actions before and during my time as a student. I support @uaw2865 and @uaw2865davis

[David Cutler @david_j_cutler]

@PetrovADmitri Being my overly formal, I might say there is no such thing in natural systems. If the strength of selection is sufficiently strong to be well measured, it is fast relative to recombination, and the target locus is formally unknowable (good guesses possible, but unprovable).

[David Cutler @david_j_cutler]

@rdhernand @UCSF_PROPEL Best of luck!!!!

[LaRonda Robinson @JamaicanVision]

I was seven years old. It’s not ancient history, it’s current reality.

[David Cutler @david_j_cutler]

@PetrovADmitri Because they know you steal their flies and worms and want to wake you up as punishment. Either that, or it's the earliest time of day to safely attempt to attract a mate (night time is owned by Owls) and there is positive selective pressure to go as "early as possible."

[David Cutler @david_j_cutler]

@pastramimachine @DDaCrema1 UC Davis trained scum right there...let your freak flag fly.

[John Cleese @JohnCleese]

With the benefit of hindsight, would you say that the Nuremberg Trials were divisive ?

[David Cutler @david_j_cutler]

@pastramimachine The best part of this Waddington-esque "2nd synthesis" of Natural Selection is not only does it pre-date the Nüsslein-Volhard work that it cites as inspiration, but pre-dates the modern synthesis itself. Like Simpson and Mayr were not actually in part responses to Waddington!

[David Cutler @david_j_cutler]

If you are inclined to spend much time worrying about the difference in votes between Warnock and Ossoff, the first thing to note is, on a county by county basis, the correlation in vote count between the two is 99.9994%. The "effect" you are thinking about is vanishingly small.

[David Cutler @david_j_cutler]

CNN's comments on Dekalb county is confused. As of last night, Dekalb county had accepted 289,098 early votes. Dekalb has only reported ~140k total so far, of which maybe ~92k early. There must be at least 190k unreported early votes still in Dekalb. Senate=50-50. Bedtime.

[David Cutler @david_j_cutler]

@joshgondelman This is truly a funny image, but, of course, Atkinson is talking about BlackAdder style comedy, not Bean. One of the funniest comedies of all-time might have difficulty staying in production when faced with out-of-context attacks on specific jokes. It was a mean, funny show.

[David Cutler @david_j_cutler]

Jan 5th, Election Day in GA. Unless day of turnout is at least 80% that of the Nov 3rd general election, Democrats have likely banked enough votes to win. Whoever you support in this election, today is your last chance to vote, and the final counts are likely very close!!!