2 ways to become famous in cardiology:
1) Work hard, contribute something meaningful
2) Hope that your name is serendipitously chosen as the acronym for a large clinical study
#ESCCongress@BrighamFellows
Although DAPA ACT HF-TIMI 68 on SGLT-2 I in AHF is formally a "negative" trial, overall survival and subsequent meta-analytic data confirm the need for early flozination in HF patients
@ddbergMD
https://t.co/WrktXpQ17m
1/ In this #SimPub paper in @CircAHA from #ESCCongress, Berg et al report the findings of the DAPA ACT HF-TIMI 68 trial that investigated the efficacy & safety of in-hospital initiation of dapagliflozin in pts hospitalized for HF
Here's a summary🧵
🔗https://t.co/GqU8R8jobk
🚨 Hot Line 2 at #ESCCongress: DAPA ACT HF results are out!
🔹 No significant reduction in CV death or worsening HF at 2 months
🔹 Overall data still support early SGLT2i use
🔹 Safety profile consistent
@escardio@ddbergMD@TIMIStudyGroup
ESC Congress Madrid 2025
HOT LINE 2
30 August from 08:15 to 09:45
Rationale and Design of the Dapagliflozin Effect on Cardiovascular Events in Acute Heart Failure (DAPA ACT HF)-TIMI 68 Trial
Optimizing guideline-directed chronic HF therapies during HF hospitalization can improve postdischarge outcomes.
Limited data exist regarding the efficacy and safety of initiating SGLT2is in hospitalized patients with HF.
DAPA ACT HF-TIMI 68 is a cardiovascular outcomes trial evaluating the initiation of dapagliflozin vs placebo in patients hospitalized for the management of acute HF.
The trial has enrolled a high proportion of patients with de novo HF, Black race, and those treated with an angiotensin receptor–neprilysin inhibitor
https://t.co/H8PuRGcRto
In an analysis of pts w/cardiogenic shock from the @CCCTNetwork registry, PAHR (HR*RAP/MAP) was strongly associated with in-hospital mortality and outperformed traditional hemodynamic metrics @ddbergMD@CurtGinder#AHA24
In contemporary CICUs, target temperatures for comatose cardiac arrest patients have shifted towards normothermia since publication of the TTM2 Trial. @rwarissmd@ddbergMD@CCCTNetwork#AHA24
In the first look at the AHA CS Registry, clinician-assigned SCAI staging effectively stratified risk of mortality in patients with CS, supporting clinical translation of SCAI staging to a broad CS population. @ddbergMD@American_Heart#AHA24
Dr. Robert Ariss presents his oral abstract on Trends In Temperature Control After Cardiac Arrest In Cardiac Intensive Care Units in this @CCCTNetwork analysis, tomorrow at 8am in S101A @rwarissmd@ddbergmd#AHA24
Cardiogenic Shock session at #ACC24
Dr. Morrow @BrighamWomens discusses
🔺complexity of the syndrome
🔺complexity of care
🔺paucity of high quality evidence
Need for team-based approach ⤵️
An approach to medical management of mixed shock states guided by hemodynamics and volume assessment.
A full link to the paper: https://t.co/8TPlGlSr3b
5/5
📜CCCTN analysis from @ddberg demonstrates the feasibility & utility of the Shock Academic Research Consortium (SHARC) Consensus Definitions for identifying discrete subtypes of CS - each with distinct clinical profiles and 📊 prognostic implications.
https://t.co/yVEFO7FXGg
The pre-shock ↔️ classic cardiogenic #shock continuum
💡What are the implications of an isolated low CO or isolated hypotension without end-organ injury?
💡 What about normotensive CS?
Now in @JACCJournals#JACCJF from @CCCTNetwork@TIMIStudyGroup
https://t.co/Zq0Jza2uDM
Dr. @BrianBergmark joins @marstonMD and @ddbergMD for the final episode of Season 2 of #TIMITalks, to discuss the Bridge-TIMI 73a trial and triglyceride lowering therapies. Listen on all major podcast platforms.