Just published in JACC @JACCJournals!🫀
Acute HF care is evolving:
📍Rapid diagnosis
📍Early decongestion
📍Timely GDMT initiation
📍Structured follow-up
📍Focus on long-term outcomes, not just symptom relief
Grateful to have contributed to this international collaboration & learned so much from the exceptional experts involved in this work. Congratulations to @Jolie_Bruno_ and @AlexMebazaa for the leadership & to all co-authors on this important publication🫀
Read the full paper🔗: https://t.co/408QmNOznr
#HeartFailure #AcuteHeartFailure #JACC @jozinetm@BiykemB@GianluSava@pmyhre
🫀MINOCA is finally entering the era of precision medicine.
The PROMISE trial is the first randomized study showing that a structured diagnostic approach with mechanism targeted therapy improves outcomes in patients with myocardial infarction and non obstructive coronary arteries (MINOCA).
The most important finding was not mortality.
It was diagnostic clarity.
Using OCT, vasoreactivity testing, CMR, and embolic evaluation, investigators identified the underlying mechanism in 80% of patients and reclassified the initial diagnosis in 75.5%.
The most frequent mechanisms were:
• Epicardial spasm: 35.6%
• Plaque instability: 22.2%
• SCAD: 13.3%
This matters because MINOCA is not one disease.
Treating vasospasm, embolism, SCAD, and plaque rupture with the same empirical post MI regimen may be ineffective or even harmful. The paper specifically highlights that beta blockers may worsen vasospastic disease, while antiplatelet therapy alone may be inadequate in coronary embolism.
The intervention improved Seattle Angina Questionnaire scores by +9.38 points, exceeding the clinically meaningful threshold.
One major message from this trial: MINOCA should no longer be considered a “diagnosis.”
It is a working syndrome that demands phenotyping.
Future ACS pathways may increasingly incorporate:
• routine CMR
• intracoronary imaging
• vasoreactivity testing
• mechanism specific therapy
This is likely the beginning of a major paradigm shift in ischemic heart disease.
Reference 📚
Montone RA et al. Stratified treatment of myocardial infarction with non obstructive coronary arteries: the PROMISE trial. European Heart Journal. 2026;47:1456–1466. https://t.co/5vXc6Qy8Q9
🗣️ “banyak orang jadi tidak menarik setelah kita tau cara berpikir mereka”
that the reason kenapa gue selalu jatuh cinta sama orang yg punya pemikiran yg luas, pembawaan yg tenang, ngerti ‘how to be a human’, punya banyak sudut pandang, paham boundaries, gak pernah memandang rendah suatu hal.
“yg membedakan manusia satu dengan yg lain, adalah isi kepala nya ✨”
Ini sebenernya ada gerakan apa kok pada demonize dokter dan nakes di negara ini? Kalian kalo emang dari awal ga percaya sama dokter Indonesia atau nakes yg lain, sangat boleh nyoba berobat ke negara tetangga yang sangat kalian agung-agungin itu. Disini jelek-jelekin tp kalo sakit
Uda ditahap ditunjuk dan dipaksa ikut lomba ekg di acara nasional pun gak tertarik.
Mikir biaya kesana dibayar sendiri + harus dftar simpo, cuti prolong tambahan stase, toh ga bakal menang juga.
Hahaha, pesimis ya? Ga ada support sama sekali dr departemen, ngapain dipaksain?
Jangan jahat jahat sama nakes dan named. Gaji tenaga medis/kesehatan di Indo itu jauh lebih rendah dari negara lain. The system already treats us badly. Don’t make it worse for us. We’ve suffered enough
Pergi ke pasar ketemu petani
Pulangnya iseng beli roti
Ada shoutout nih dari SHINee
Ngajakin kamu nonton Jumat nanti!
🎥 2026 SHINee WORLD VIII : [THE INVERT] IN CINEMAS
📆 Jumat, 29 Mei 2026
🎟️ Beli tiketnya sekarang di app & web CGV!
#SHINee #샤이니
#2026_SHINeeWORLD_VIII_THE_INVERT_IN_CINEMAS #SemuSerudiCGV
Satu panggung. Satu cahaya. Dan jutaan kenangan bersama. 💎✨
Mari rayakan momen spesial ini bersama SHINee di layar lebar.
SHINee WORLD VIII : [THE INVERT] IN CINEMAS, tayang mulai hari ini di Cinépolis Cinemas.
Book tiketmu di website dan aplikasi Cinépolis Indonesia.
Absen dulu yuk yang mau nonton SHINee WORLD VIII: THE INVERT di Cinépolis Cinemas! ✨
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#SHINeeWORLD_VI#CinepolisID
@tix_id halo kak, saya mau pesen presale tiket bioskop SWC SHINee pake aplikasi tix id, gmna ya caranya? Blm masuk ke daftar film di Medan tp udh showing di jakarta.